ENSMUSG00000013629


Mus musculus

Features
Gene ID: ENSMUSG00000013629
  
Biological name :Cad
  
Synonyms : B2RQC6 / Cad / CAD protein Glutamine-dependent carbamoyl-phosphate synthase Aspartate carbamoyltransferase Dihydroorotase
  
Possible biological names infered from orthology : carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase / P27708
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: B1
Gene start: 31054780
Gene end: 31078479
  
Corresponding Affymetrix probe sets: 10520650 (MoGene1.0st)   1440857_at (Mouse Genome 430 2.0 Array)   1452829_at (Mouse Genome 430 2.0 Array)   1452830_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000144307
Ensembl peptide - ENSMUSP00000144127
Ensembl peptide - ENSMUSP00000144679
Ensembl peptide - ENSMUSP00000144684
Ensembl peptide - ENSMUSP00000013773
Ensembl peptide - ENSMUSP00000144009
NCBI entrez gene - 69719     See in Manteia.
MGI - MGI:1916969
RefSeq - XM_006504092
RefSeq - NM_001289522
RefSeq - NM_001289523
RefSeq - NM_023525
RefSeq - XM_006504091
RefSeq Peptide - NP_001276451
RefSeq Peptide - NP_076014
RefSeq Peptide - NP_001276452
swissprot - F6S3Z3
swissprot - G3UWN2
swissprot - E9QAI5
swissprot - B2RQC6
swissprot - E9QAT6
Ensembl - ENSMUSG00000013629
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cadENSDARG00000041895Danio rerio
 CADENSGALG00000016524Gallus gallus
 CADENSG00000084774Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cps1 / Q8C196 / Carbamoyl-phosphate synthase [ammonia], mitochondrial / P31327* / carbamoyl-phosphate synthase 1*ENSMUSG0000002599134


Protein motifs (from Interpro)
Interpro ID Name
 IPR002082  Aspartate carbamoyltransferase
 IPR002195  Dihydroorotase, conserved site
 IPR002474  Carbamoyl-phosphate synthase small subunit, N-terminal domain
 IPR005479  Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain
 IPR005480  Carbamoyl-phosphate synthetase, large subunit oligomerisation domain
 IPR005483  Carbamoyl-phosphate synthase large subunit, CPSase domain
 IPR006130  Aspartate/ornithine carbamoyltransferase
 IPR006131  Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain
 IPR006132  Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding
 IPR006274  Carbamoyl-phosphate synthase, small subunit
 IPR006275  Carbamoyl-phosphate synthase, large subunit
 IPR006680  Amidohydrolase-related
 IPR011059  Metal-dependent hydrolase, composite domain superfamily
 IPR011607  Methylglyoxal synthase-like domain
 IPR011761  ATP-grasp fold
 IPR013815  ATP-grasp fold, subdomain 1
 IPR016185  Pre-ATP-grasp domain superfamily
 IPR017926  Glutamine amidotransferase
 IPR029062  Class I glutamine amidotransferase-like
 IPR032466  Metal-dependent hydrolase
 IPR035686  Carbamoyl-phosphate synthase small subunit, GATase1 domain
 IPR036480  Carbamoyl-phosphate synthase small subunit, N-terminal domain superfamily
 IPR036897  Carbamoyl-phosphate synthetase, large subunit oligomerisation domain superfamily
 IPR036901  Aspartate/ornithine carbamoyltransferase superfamily
 IPR036914  Methylglyoxal synthase-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000050 urea cycle IBA
 biological_processGO:0001889 liver development IEA
 biological_processGO:0006207 "de novo" pyrimidine nucleobase biosynthetic process IEA
 biological_processGO:0006221 pyrimidine nucleotide biosynthetic process IEA
 biological_processGO:0006228 UTP biosynthetic process IEA
 biological_processGO:0006520 cellular amino acid metabolic process IEA
 biological_processGO:0006526 arginine biosynthetic process IBA
 biological_processGO:0006541 glutamine metabolic process IEA
 biological_processGO:0006807 nitrogen compound metabolic process IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0007565 female pregnancy IEA
 biological_processGO:0007595 lactation IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0014075 response to amine IEA
 biological_processGO:0017144 drug metabolic process IEA
 biological_processGO:0018107 peptidyl-threonine phosphorylation ISO
 biological_processGO:0019240 citrulline biosynthetic process IEA
 biological_processGO:0031000 response to caffeine IEA
 biological_processGO:0031100 animal organ regeneration IEA
 biological_processGO:0032868 response to insulin IEA
 biological_processGO:0033574 response to testosterone IEA
 biological_processGO:0035690 cellular response to drug IEA
 biological_processGO:0042594 response to starvation IEA
 biological_processGO:0044205 "de novo" UMP biosynthetic process IEA
 biological_processGO:0046777 protein autophosphorylation ISO
 biological_processGO:0051414 response to cortisol IEA
 biological_processGO:0071364 cellular response to epidermal growth factor stimulus IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0016363 nuclear matrix ISO
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043195 terminal bouton IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0002134 UTP binding ISO
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004070 aspartate carbamoyltransferase activity IEA
 molecular_functionGO:0004087 carbamoyl-phosphate synthase (ammonia) activity IBA
 molecular_functionGO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity IEA
 molecular_functionGO:0004151 dihydroorotase activity IBA
 molecular_functionGO:0004672 protein kinase activity ISO
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008270 zinc ion binding ISS
 molecular_functionGO:0016597 amino acid binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016743 carboxyl- or carbamoyltransferase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IEA
 molecular_functionGO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides IEA
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0019899 enzyme binding ISO
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Pyrimidine biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000013629 Cad / B2RQC6 / CAD protein Glutamine-dependent carbamoyl-phosphate synthase Aspartate carbamoyltransferase Dihydroorotase / P27708* / carbamoyl-phosphate synthetase 2, aspartate transcarbam...  / complex






 

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