ENSMUSG00000025991


Mus musculus

Features
Gene ID: ENSMUSG00000025991
  
Biological name :Cps1
  
Synonyms : Carbamoyl-phosphate synthase [ammonia], mitochondrial / Cps1 / Q8C196
  
Possible biological names infered from orthology : carbamoyl-phosphate synthase 1 / P31327
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: C3
Gene start: 67123026
Gene end: 67231259
  
Corresponding Affymetrix probe sets: 10347117 (MoGene1.0st)   1455540_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027144
NCBI entrez gene - 227231     See in Manteia.
MGI - MGI:891996
RefSeq - NM_001080809
RefSeq - XM_011238500
RefSeq Peptide - NP_001074278
swissprot - Q8C196
Ensembl - ENSMUSG00000025991
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cps1ENSDARG00000020028Danio rerio
 CPS1ENSGALG00000002944Gallus gallus
 CPS1ENSG00000021826Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cad / B2RQC6 / CAD protein Glutamine-dependent carbamoyl-phosphate synthase Aspartate carbamoyltransferase Dihydroorotase / P27708* / carbamoyl-phosphate synthetase 2, aspartate transcarbam...ENSMUSG0000001362950


Protein motifs (from Interpro)
Interpro ID Name
 IPR002474  Carbamoyl-phosphate synthase small subunit, N-terminal domain
 IPR005479  Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain
 IPR005480  Carbamoyl-phosphate synthetase, large subunit oligomerisation domain
 IPR005483  Carbamoyl-phosphate synthase large subunit, CPSase domain
 IPR006274  Carbamoyl-phosphate synthase, small subunit
 IPR006275  Carbamoyl-phosphate synthase, large subunit
 IPR011607  Methylglyoxal synthase-like domain
 IPR011761  ATP-grasp fold
 IPR013815  ATP-grasp fold, subdomain 1
 IPR016185  Pre-ATP-grasp domain superfamily
 IPR017926  Glutamine amidotransferase
 IPR029062  Class I glutamine amidotransferase-like
 IPR035686  Carbamoyl-phosphate synthase small subunit, GATase1 domain
 IPR036480  Carbamoyl-phosphate synthase small subunit, N-terminal domain superfamily
 IPR036897  Carbamoyl-phosphate synthetase, large subunit oligomerisation domain superfamily
 IPR036914  Methylglyoxal synthase-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000050 urea cycle IC
 biological_processGO:0001889 liver development IEA
 biological_processGO:0006207 "de novo" pyrimidine nucleobase biosynthetic process IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006526 arginine biosynthetic process IBA
 biological_processGO:0006541 glutamine metabolic process IEA
 biological_processGO:0006807 nitrogen compound metabolic process IEA
 biological_processGO:0007494 midgut development IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0010043 response to zinc ion IEA
 biological_processGO:0014075 response to amine IEA
 biological_processGO:0019433 triglyceride catabolic process IEA
 biological_processGO:0032094 response to food IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0033762 response to glucagon IEA
 biological_processGO:0034201 response to oleic acid IEA
 biological_processGO:0042311 vasodilation IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042594 response to starvation IEA
 biological_processGO:0043200 response to amino acid IEA
 biological_processGO:0044344 cellular response to fibroblast growth factor stimulus IEA
 biological_processGO:0046209 nitric oxide metabolic process IEA
 biological_processGO:0048545 response to steroid hormone IEA
 biological_processGO:0050667 homocysteine metabolic process IEA
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0051591 response to cAMP IEA
 biological_processGO:0055081 anion homeostasis IEA
 biological_processGO:0060416 response to growth hormone IEA
 biological_processGO:0070365 hepatocyte differentiation IEA
 biological_processGO:0070409 carbamoyl phosphate biosynthetic process IEA
 biological_processGO:0071320 cellular response to cAMP IEA
 biological_processGO:0071377 cellular response to glucagon stimulus IEA
 biological_processGO:0071400 cellular response to oleic acid IEA
 biological_processGO:0071548 response to dexamethasone IEA
 biological_processGO:1903718 cellular response to ammonia IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0042645 mitochondrial nucleoid IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004087 carbamoyl-phosphate synthase (ammonia) activity ISO
 molecular_functionGO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity IBA
 molecular_functionGO:0004175 endopeptidase activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0005543 phospholipid binding IEA
 molecular_functionGO:0016595 glutamate binding IEA
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0072341 modified amino acid binding IEA


Pathways (from Reactome)
Pathway description
Urea cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0005309 increased circulating ammonia level "significantly elevated levels of ammonia or its compounds in blood; often associated with liver failure and hepatic encephalopathy " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83263]
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Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Tg(KRT14-cre)52Smr/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL/J

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Tg(KRT14-cre)52Smr/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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