ENSMUSG00000000631


Mus musculus

Features
Gene ID: ENSMUSG00000000631
  
Biological name :Myo18a
  
Synonyms : Myo18a / myosin XVIIIA / Q9JMH9
  
Possible biological names infered from orthology : Q92614
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B5
Gene start: 77763246
Gene end: 77865980
  
Corresponding Affymetrix probe sets: 10378914 (MoGene1.0st)   1451422_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000123256
Ensembl peptide - ENSMUSP00000119839
Ensembl peptide - ENSMUSP00000128487
Ensembl peptide - ENSMUSP00000132149
Ensembl peptide - ENSMUSP00000131771
Ensembl peptide - ENSMUSP00000130696
Ensembl peptide - ENSMUSP00000129098
Ensembl peptide - ENSMUSP00000129084
Ensembl peptide - ENSMUSP00000000645
Ensembl peptide - ENSMUSP00000090560
Ensembl peptide - ENSMUSP00000090563
Ensembl peptide - ENSMUSP00000098358
Ensembl peptide - ENSMUSP00000099546
Ensembl peptide - ENSMUSP00000104012
Ensembl peptide - ENSMUSP00000104013
Ensembl peptide - ENSMUSP00000117044
Ensembl peptide - ENSMUSP00000119574
NCBI entrez gene - 360013     See in Manteia.
MGI - MGI:2667185
RefSeq - XM_017314630
RefSeq - XM_006533606
RefSeq - XM_006533610
RefSeq - XM_006533611
RefSeq - XM_006533612
RefSeq - XM_006533614
RefSeq - XM_011249090
RefSeq - XM_011249092
RefSeq - XM_017314622
RefSeq - XM_017314623
RefSeq - XM_017314624
RefSeq - XM_017314625
RefSeq - XM_017314626
RefSeq - XM_017314627
RefSeq - XM_017314628
RefSeq - XM_017314629
RefSeq - NM_001291212
RefSeq - NM_001291213
RefSeq - NM_001291214
RefSeq - NM_001291215
RefSeq - NM_011586
RefSeq - XM_006533596
RefSeq - XM_006533597
RefSeq - XM_006533598
RefSeq - XM_006533600
RefSeq - XM_006533601
RefSeq - XM_006533603
RefSeq - XM_006533604
RefSeq Peptide - NP_035716
RefSeq Peptide - NP_001278143
RefSeq Peptide - NP_001278144
RefSeq Peptide - NP_001278141
RefSeq Peptide - NP_001278142
swissprot - F6ZGN3
swissprot - K3W4L0
swissprot - E9QAX2
swissprot - Q9JMH9
swissprot - A0A1C7ZN10
swissprot - B2RRE2
swissprot - E9QA74
swissprot - E9Q405
swissprot - E9Q0K8
swissprot - E9PUR2
Ensembl - ENSMUSG00000000631
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 myo18aaENSDARG00000075752Danio rerio
 myo18abENSDARG00000061862Danio rerio
 MYO18AENSGALG00000003741Gallus gallus
 MYO18AENSG00000196535Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Myo18b / myosin XVIIIB / Q8IUG5*ENSMUSG0000007272038


Protein motifs (from Interpro)
Interpro ID Name
 IPR000048  IQ motif, EF-hand binding site
 IPR001478  PDZ domain
 IPR001609  Myosin head, motor domain
 IPR002928  Myosin tail
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR031244  Unconventional myosin-XVIIIa
 IPR036034  PDZ superfamily
 IPR036064  Class XVIII myosin, motor domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007018 microtubule-based movement IEA
 biological_processGO:0007030 Golgi organization ISS
 biological_processGO:0016477 cell migration ISS
 biological_processGO:0031032 actomyosin structure organization ISS
 biological_processGO:0043030 regulation of macrophage activation IMP
 biological_processGO:0043066 negative regulation of apoptotic process ISO
 biological_processGO:0048194 Golgi vesicle budding ISO
 biological_processGO:0050714 positive regulation of protein secretion ISS
 biological_processGO:0071346 cellular response to interferon-gamma IDA
 biological_processGO:0090161 Golgi ribbon formation ISO
 biological_processGO:0090164 asymmetric Golgi ribbon formation ISO
 biological_processGO:1903028 positive regulation of opsonization IMP
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005793 endoplasmic reticulum-Golgi intermediate compartment IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005802 trans-Golgi network ISO
 cellular_componentGO:0005856 cytoskeleton IDA
 cellular_componentGO:0005903 brush border IDA
 cellular_componentGO:0016459 myosin complex IEA
 cellular_componentGO:0042641 actomyosin ISO
 cellular_componentGO:0045335 phagocytic vesicle IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003774 motor activity IEA
 molecular_functionGO:0003777 microtubule motor activity IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0043531 ADP binding ISO
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
Show

Allelic Composition: Myh1tm1b(KOMP)Wtsi/Myh1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Myh1tm1b(KOMP)Wtsi/J

 MP:0001293 anophthalmia "congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979]
Show

Allelic Composition: Mogstm1.1(KOMP)Vlcg/Mogstm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Mogstm1.1(KOMP)Vlcg/Bay

 MP:0001697 abnormal embryo size "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Myh1tm1b(KOMP)Wtsi/Myh1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Myh1tm1b(KOMP)Wtsi/J

Allelic Composition: Myo18atm1b(KOMP)Wtsi/Myo18a+
Genetic Background: C57BL/6N-Myo18atm1b(KOMP)Wtsi/Ucd

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
Show

Allelic Composition: Myh1tm1b(KOMP)Wtsi/Myh1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Myh1tm1b(KOMP)Wtsi/J

Allelic Composition: Myo18atm1b(KOMP)Wtsi/Myo18a+
Genetic Background: C57BL/6N-Myo18atm1b(KOMP)Wtsi/Ucd

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Myh1tm1b(KOMP)Wtsi/Myh1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Myh1tm1b(KOMP)Wtsi/J

 MP:0004086 absent heartbeat "lack of a spontaneously beating heart (usually due to defects in the calcium delivery mechanism or loss of a functional contractile apparatus)" [J:69362, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Myh1tm1b(KOMP)Wtsi/Myh1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Myh1tm1b(KOMP)Wtsi/J

Allelic Composition: Myo18atm1b(KOMP)Wtsi/Myo18a+
Genetic Background: C57BL/6N-Myo18atm1b(KOMP)Wtsi/Ucd

 MP:0004258 abnormal placenta size "anomaly in the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myh1tm1b(KOMP)Wtsi/Myh1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Myh1tm1b(KOMP)Wtsi/J

 MP:0005650 abnormal limb bud morphology "aberrant structure or development of any of the swellings on the trunk of the embryo that become limbs" [hdene:Howard Dene , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:61460]
Show

Allelic Composition: Myh1tm1b(KOMP)Wtsi/Myh1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Myh1tm1b(KOMP)Wtsi/J

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Myh1tm1b(KOMP)Wtsi/Myh1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Myh1tm1b(KOMP)Wtsi/J

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
Show

Allelic Composition: Myh1tm1b(KOMP)Wtsi/Myh1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Myh1tm1b(KOMP)Wtsi/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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