ENSMUSG00000001156


Mus musculus

Features
Gene ID: ENSMUSG00000001156
  
Biological name :Mxd1
  
Synonyms : MAX dimerization protein 1 / Mxd1
  
Possible biological names infered from orthology : Q05195
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: D1
Gene start: 86647042
Gene end: 86669161
  
Corresponding Affymetrix probe sets: 10545921 (MoGene1.0st)   1422002_at (Mouse Genome 430 2.0 Array)   1434830_at (Mouse Genome 430 2.0 Array)   1455104_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000001184
Ensembl peptide - ENSMUSP00000145396
Ensembl peptide - ENSMUSP00000145081
NCBI entrez gene - 17119     See in Manteia.
MGI - MGI:96908
RefSeq - NM_010751
RefSeq - XM_006505670
RefSeq Peptide - NP_034881
swissprot - A0A0N4SW68
swissprot - Q8K1Z8
swissprot - A0A0N4SVF6
Ensembl - ENSMUSG00000001156
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mxd1ENSDARG00000032039Danio rerio
 MXD1ENSGALG00000013882Gallus gallus
 MXD1ENSG00000059728Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mxi1 / P50540 / Max-interacting protein 1 / P50539* / MAX interactor 1, dimerization protein*ENSMUSG0000002502553
Mxd3 / Q80US8 / Max dimerization protein 3 / Q9BW11*ENSMUSG0000002148536
Mxd4 / MAX dimerization protein 4 / Q14582*ENSMUSG0000003723535


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ghrtm1Jjk/Ghrtm1Jjk
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ghrtm1Jjk/Ghrtm1Jjk
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ghrtm1Jjk/Ghrtm1Jjk
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0008250 abnormal myeloid leukocyte morphology "any structural anomaly of a cell of the monocyte, granulocyte, or mast cell lineage" [CL:0000766]
Show

Allelic Composition: Ghrtm1Jjk/Ghrtm1Jjk
Genetic Background: involves: 129P2/OlaHsd * BALB/c

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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