ENSMUSG00000025025


Mus musculus

Features
Gene ID: ENSMUSG00000025025
  
Biological name :Mxi1
  
Synonyms : Max-interacting protein 1 / Mxi1 / P50540
  
Possible biological names infered from orthology : MAX interactor 1, dimerization protein / P50539
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: D2
Gene start: 53310506
Gene end: 53375810
  
Corresponding Affymetrix probe sets: 10463930 (MoGene1.0st)   1425732_a_at (Mouse Genome 430 2.0 Array)   1450376_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000003870
Ensembl peptide - ENSMUSP00000025998
Ensembl peptide - ENSMUSP00000107366
NCBI entrez gene - 17859     See in Manteia.
MGI - MGI:97245
RefSeq - XM_017318079
RefSeq - NM_001008542
RefSeq - NM_001008543
RefSeq - NM_010847
RefSeq - XM_006526735
RefSeq - XM_006526738
RefSeq - XM_006526739
RefSeq - XM_006526740
RefSeq - XM_006526741
RefSeq Peptide - NP_001008542
RefSeq Peptide - NP_001008543
RefSeq Peptide - NP_034977
swissprot - P50540
swissprot - Q3U3X2
swissprot - Q3USD3
Ensembl - ENSMUSG00000025025
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mxi1ENSDARG00000040884Danio rerio
 MXI1ENSGALG00000008555Gallus gallus
 MXI1ENSG00000119950Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mxd1 / MAX dimerization protein 1 / Q05195*ENSMUSG0000000115641
Mxd4 / MAX dimerization protein 4 / Q14582*ENSMUSG0000003723530
Mxd3 / Q80US8 / Max dimerization protein 3 / Q9BW11*ENSMUSG0000002148528


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005730 nucleolus ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0090575 RNA polymerase II transcription factor complex ISO
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: C57BL/6

 MP:0001158 abnormal prostate morphology "mallformed gland in males that secretes part of the seminiferous fluid" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:63764]
Show

Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: C57BL/6

 MP:0001167 prostate epithelial hyperplasia "epithelium is multi-layered instead of columnar with increased cell number" [J:63764]
Show

Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: C57BL/6

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Mxi1tm1Rdp/Mxi1tm1Rdp
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: C57BL/6

 MP:0002619 abnormal lymphocyte morphology/development "anomalous structure, differentiation, or number of the white blood cells formed in the body s lymphoid tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: C57BL/6

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: C57BL/6

 MP:0004756 abnormal proximal convoluted tubule morphology "any structural anomaly of the convoluted portion of the duct system of the nephron that extends from the renal glomeurlar capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle; fluid entering the proximal convoluted tubule is reabsorbed into the peritubular capillaries, including approximately two-thirds of the filtered salt and water and all filtered organic solutes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: C57BL/6

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: C57BL/6

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: C57BL/6

 MP:0008478 increased spleen white pulp amount "increase in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: C57BL/6

 MP:0009641 kidney degeneration "a retrogressive impairment of function or destruction of either or both of the two excretory organs that filter wastes (especially urea) from the blood and excrete them and water in urine" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: C57BL/6

 MP:0011363 renal glomerulus atrophy "acquired diminution of the size of the capillary loops of the kidney associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]
Show

Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: C57BL/6

 MP:0011423 kidney cortex atrophy "acquired diminution of the size of the outer portion of the kidney located between the renal capsule and the renal medulla, associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]
Show

Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: C57BL/6

 MP:0011501 increased glomerular capsule space "increased volume of the luminal region between the glomerular capsule visceral and parietal layers, into which filtrate enters after passing through the filtration barrier from the glomerular capillaries" [MGI:csmith]
Show

Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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