ENSG00000119950


Homo sapiens

Features
Gene ID: ENSG00000119950
  
Biological name :MXI1
  
Synonyms : MAX interactor 1, dimerization protein / MXI1 / P50539
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: 1
Band: q25.2
Gene start: 110207605
Gene end: 110287365
  
Corresponding Affymetrix probe sets: 202364_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000354606
Ensembl peptide - ENSP00000407711
Ensembl peptide - ENSP00000398981
Ensembl peptide - ENSP00000376842
Ensembl peptide - ENSP00000358625
Ensembl peptide - ENSP00000239007
Ensembl peptide - ENSP00000331152
NCBI entrez gene - 4601     See in Manteia.
OMIM - 600020
RefSeq - NM_130439
RefSeq - NM_001008541
RefSeq - NM_005962
RefSeq Peptide - NP_005953
RefSeq Peptide - NP_001008541
RefSeq Peptide - NP_569157
swissprot - P50539
swissprot - A0A0S2Z3Y0
swissprot - A0A0S2Z3X5
swissprot - F6U3F6
swissprot - F6WCI9
swissprot - B1ANN8
Ensembl - ENSG00000119950
  
Related genetic diseases (OMIM): 176807 - {Prostate cancer, susceptibility to}, 176807
  600020 - Neurofibrosarcoma

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mxi1ENSDARG00000040884Danio rerio
 MXI1ENSGALG00000008555Gallus gallus
 Mxi1ENSMUSG00000025025Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MXD1 / Q05195 / MAX dimerization protein 1ENSG0000005972841
MXD3 / Q9BW11 / MAX dimerization protein 3ENSG0000021334728
MXD4 / Q14582 / MAX dimerization protein 4ENSG0000012393328


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0008285 negative regulation of cell proliferation TAS
 biological_processGO:0042994 cytoplasmic sequestering of transcription factor TAS
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0090575 RNA polymerase II transcription factor complex IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IC
 molecular_functionGO:0003677 DNA binding TAS
 molecular_functionGO:0003714 transcription corepressor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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