ENSG00000059728


Homo sapiens

Features
Gene ID: ENSG00000059728
  
Biological name :MXD1
  
Synonyms : MAX dimerization protein 1 / MXD1 / Q05195
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: p13.3
Gene start: 69897688
Gene end: 69942945
  
Corresponding Affymetrix probe sets: 206877_at (Human Genome U133 Plus 2.0 Array)   226275_at (Human Genome U133 Plus 2.0 Array)   228846_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000443935
Ensembl peptide - ENSP00000264444
Ensembl peptide - ENSP00000386523
Ensembl peptide - ENSP00000410672
NCBI entrez gene - 4084     See in Manteia.
OMIM - 600021
RefSeq - NM_001202513
RefSeq - NM_002357
RefSeq - NM_001202514
RefSeq Peptide - NP_001189442
RefSeq Peptide - NP_002348
RefSeq Peptide - NP_001189443
swissprot - Q05195
swissprot - C9JBE8
swissprot - F8WBI0
Ensembl - ENSG00000059728
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mxd1ENSDARG00000032039Danio rerio
 MXD1ENSGALG00000013882Gallus gallus
 Mxd1ENSMUSG00000001156Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MXI1 / P50539 / MAX interactor 1, dimerization proteinENSG0000011995054
MXD3 / Q9BW11 / MAX dimerization protein 3ENSG0000021334738
MXD4 / Q14582 / MAX dimerization protein 4ENSG0000012393335


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development TAS
 biological_processGO:0008283 cell proliferation TAS
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity TAS
 molecular_functionGO:0003712 transcription coregulator activity TAS
 molecular_functionGO:0003714 transcription corepressor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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