ENSMUSG00000021485


Mus musculus

Features
Gene ID: ENSMUSG00000021485
  
Biological name :Mxd3
  
Synonyms : Max dimerization protein 3 / Mxd3 / Q80US8
  
Possible biological names infered from orthology : Q9BW11
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: B1
Gene start: 55325168
Gene end: 55329823
  
Corresponding Affymetrix probe sets: 10409424 (MoGene1.0st)   1422970_at (Mouse Genome 430 2.0 Array)   1438847_at (Mouse Genome 430 2.0 Array)   1448878_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021941
NCBI entrez gene - 17121     See in Manteia.
MGI - MGI:104987
RefSeq - NM_016662
RefSeq Peptide - NP_057871
swissprot - Q80US8
Ensembl - ENSMUSG00000021485
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mxd3ENSDARG00000098350Danio rerio
 MXD3ENSGALG00000046263Gallus gallus
 MXD3ENSG00000213347Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mxi1 / P50540 / Max-interacting protein 1 / P50539* / MAX interactor 1, dimerization protein*ENSMUSG0000002502540
Mxd1 / MAX dimerization protein 1 / Q05195*ENSMUSG0000000115639
Mxd4 / MAX dimerization protein 4 / Q14582*ENSMUSG0000003723530


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IGI
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0090575 RNA polymerase II transcription factor complex IMP
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IMP
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IMP
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002007 increased sensitivity to gamma-irradiation "increased incidence of cell death following high levels of gamma-irradiation" [J:51834]
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Allelic Composition: Atp2b2dfw-2J/Atp2b2+
Genetic Background: CByJ.A-Atp2b2dfw-2J/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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