ENSMUSG00000003484


Mus musculus

Features
Gene ID: ENSMUSG00000003484
  
Biological name :Cyp4f18
  
Synonyms : Cyp4f18 / Leukotriene-B(4) omega-hydroxylase 2 / Q99N16
  
Possible biological names infered from orthology : CYP4F3 / cytochrome P450 family 4 subfamily F member 3 / Q08477
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: B3.3
Gene start: 71988482
Gene end: 72009626
  
Corresponding Affymetrix probe sets: 10579636 (MoGene1.0st)   1419219_at (Mouse Genome 430 2.0 Array)   1433389_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000003574
Ensembl peptide - ENSMUSP00000148315
NCBI entrez gene - 72054     See in Manteia.
MGI - MGI:1919304
RefSeq - XM_011242327
RefSeq - NM_024444
RefSeq - XM_006509748
RefSeq - XM_006509749
RefSeq Peptide - NP_077764
swissprot - A0A1D5RLD0
swissprot - Q99N16
Ensembl - ENSMUSG00000003484
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cyp4f3ENSDARG00000053530Danio rerio
 CYP4F3ENSG00000186529Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9EP75 / Cyp4f14 / Mus musculus cytochrome P450, family 4, subfamily f, polypeptide 14 (Cyp4f14), transcript variant 6, mRNA.ENSMUSG0000002429277
Cyp4f40 / cytochrome P450, family 4, subfamily f, polypeptide 40ENSMUSG0000009070076
Cyp4f15 / cytochrome P450, family 4, subfamily f, polypeptide 15ENSMUSG0000007342476
Cyp4f16 / cytochrome P450, family 4, subfamily f, polypeptide 16ENSMUSG0000004844075
Cyp4f17 / cytochrome P450, family 4, subfamily f, polypeptide 17ENSMUSG0000009158674
Cyp4f37 / cytochrome P450, family 4, subfamily f, polypeptide 37ENSMUSG0000006246474
Cyp4f13 / cytochrome P450, family 4, subfamily f, polypeptide 13ENSMUSG0000002405574
Cyp4f39 / cytochrome P450, family 4, subfamily f, polypeptide 39 / Q6NT55* / CYP4F22* / cytochrome P450 family 4 subfamily F member 22*ENSMUSG0000006112661
O88833 / Cyp4a10 / Cytochrome P450 4A10 / Q5TCH4* / Q02928* / CYP4A22* / CYP4A11* / cytochrome P450 family 4 subfamily A member 11* / cytochrome P450 family 4 subfamily A member 22*ENSMUSG0000006607243
Cyp4a32 / cytochrome P450, family 4, subfamily a, polypeptide 32 / Q5TCH4* / Q02928* / CYP4A11* / CYP4A22* / cytochrome P450 family 4 subfamily A member 22* / cytochrome P450 family 4 subfa...ENSMUSG0000006392943
Q91WL5 / Cyp4a12a / Cytochrome P450 4A12A / Q02928* / Q5TCH4* / CYP4A11* / CYP4A22* / cytochrome P450 family 4 subfamily A member 22* / cytochrome P450 family 4 subfamily A member 11*ENSMUSG0000006607143
Cyp4a31 / cytochrome P450, family 4, subfamily a, polypeptide 31 / Q5TCH4* / Q02928* / CYP4A11* / CYP4A22* / cytochrome P450 family 4 subfamily A member 22* / cytochrome P450 family 4 subfa...ENSMUSG0000002871242
Cyp4a12b / cytochrome P450, family 4, subfamily a, polypeptide 12B / Q5TCH4* / Q02928* / CYP4A11* / CYP4A22* / cytochrome P450 family 4 subfamily A member 22* / cytochrome P450 family 4 sub...ENSMUSG0000007859742
Cyp4b1 / Q64462 / Cytochrome P450 4B1 / P13584* / cytochrome P450 family 4 subfamily B member 1*ENSMUSG0000002871342
O35728 / Cyp4a14 / Cytochrome P450 4A14 / Q5TCH4* / Q02928* / CYP4A11* / CYP4A22* / cytochrome P450 family 4 subfamily A member 22* / cytochrome P450 family 4 subfamily A member 11*ENSMUSG0000002871541
Cyp4a29 / cytochrome P450, family 4, subfamily a, polypeptide 29 / Q5TCH4* / Q02928* / CYP4A11* / CYP4A22* / cytochrome P450 family 4 subfamily A member 22* / cytochrome P450 family 4 subfa...ENSMUSG0000008313840
Cyp4a30b / cytochrome P450, family 4, subfamily a, polypeptide 30b / Q5TCH4* / Q02928* / CYP4A11* / CYP4A22* / cytochrome P450 family 4 subfamily A member 22* / cytochrome P450 family 4 sub...ENSMUSG0000008434639
Cyp4x1 / Q6A152 / Cytochrome P450 4X1 / Q8N118* / cytochrome P450 family 4 subfamily X member 1*ENSMUSG0000004715538
Q9DBW0 / Cyp4v3 / Cytochrome P450 4V2 / CYP4V2* / Q6ZWL3* / cytochrome P450 family 4 subfamily V member 2*ENSMUSG0000007905733


Protein motifs (from Interpro)
Interpro ID Name
 IPR001128  Cytochrome P450
 IPR002401  Cytochrome P450, E-class, group I
 IPR002403  Cytochrome P450, E-class, group IV
 IPR017972  Cytochrome P450, conserved site
 IPR036396  Cytochrome P450 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000038 very long-chain fatty acid metabolic process ISO
 biological_processGO:0001676 long-chain fatty acid metabolic process ISO
 biological_processGO:0008217 regulation of blood pressure ISO
 biological_processGO:0017144 drug metabolic process ISO
 biological_processGO:0019369 arachidonic acid metabolic process ISO
 biological_processGO:0019373 epoxygenase P450 pathway ISO
 biological_processGO:0032304 negative regulation of icosanoid secretion ISO
 biological_processGO:0032305 positive regulation of icosanoid secretion ISO
 biological_processGO:0036101 leukotriene B4 catabolic process ISO
 biological_processGO:0042360 vitamin E metabolic process ISO
 biological_processGO:0042361 menaquinone catabolic process ISO
 biological_processGO:0042376 phylloquinone catabolic process ISO
 biological_processGO:0042377 vitamin K catabolic process ISO
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane ISO
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0008392 arachidonic acid epoxygenase activity ISO
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen ISO
 molecular_functionGO:0018685 alkane 1-monooxygenase activity ISO
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050051 leukotriene-B4 20-monooxygenase activity IEA
 molecular_functionGO:0052869 arachidonic acid omega-hydroxylase activity ISO
 molecular_functionGO:0052870 tocopherol omega-hydroxylase activity IEA
 molecular_functionGO:0052871 alpha-tocopherol omega-hydroxylase activity ISO
 molecular_functionGO:0052872 tocotrienol omega-hydroxylase activity ISO


Pathways (from Reactome)
Pathway description
Fatty acids
Eicosanoids
Synthesis of Leukotrienes (LT) and Eoxins (EX)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0009817 decreased leukotriene level "reduced concentration of a family of mediators derived from arachidonic acid which normally stimulate smooth muscle contraction, increase vascular permeability, and may be chemoattractants for inflammatory cells" [ISBN:0-397-51047-0 "Rubin E, et al. Pathology, 2nd edition"]
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Allelic Composition: Shh+/Shhtm1Chg,Zic2Ku/Zic2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cAnNCrl * C3H/HeH

 MP:0010953 abnormal fatty acid oxidation "anomaly in the process of removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen." [GO:0019395]
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Allelic Composition: Shh+/Shhtm1Chg,Zic2Ku/Zic2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cAnNCrl * C3H/HeH

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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