ENSMUSG00000066072


Mus musculus

Features
Gene ID: ENSMUSG00000066072
  
Biological name :Cyp4a10
  
Synonyms : Cyp4a10 / Cytochrome P450 4A10 / O88833
  
Possible biological names infered from orthology : CYP4A11 / CYP4A22 / cytochrome P450 family 4 subfamily A member 11 / cytochrome P450 family 4 subfamily A member 22 / Q02928 / Q5TCH4
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D1
Gene start: 115518264
Gene end: 115533649
  
Corresponding Affymetrix probe sets: 10507163 (MoGene1.0st)   10507177 (MoGene1.0st)   1424853_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000092486
Ensembl peptide - ENSMUSP00000061126
NCBI entrez gene - 13117     See in Manteia.
MGI - MGI:88611
RefSeq - NM_010011
RefSeq Peptide - NP_034141
swissprot - A2A977
swissprot - O88833
Ensembl - ENSMUSG00000066072
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cyp4t8ENSDARG00000004964Danio rerio
 CYP4A22ENSGALG00000020688Gallus gallus
 CYP4B7ENSGALG00000010469Gallus gallus
 Q02928ENSG00000187048Homo sapiens
 Q5TCH4ENSG00000162365Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cyp4a32 / cytochrome P450, family 4, subfamily a, polypeptide 32 / Q5TCH4* / Q02928* / CYP4A11* / CYP4A22* / cytochrome P450 family 4 subfamily A member 22* / cytochrome P450 family 4 subfa...ENSMUSG0000006392996
Cyp4a31 / cytochrome P450, family 4, subfamily a, polypeptide 31 / Q5TCH4* / Q02928* / CYP4A11* / CYP4A22* / cytochrome P450 family 4 subfamily A member 22* / cytochrome P450 family 4 subfa...ENSMUSG0000002871294
Cyp4a12b / cytochrome P450, family 4, subfamily a, polypeptide 12B / Q5TCH4* / Q02928* / CYP4A11* / CYP4A22* / cytochrome P450 family 4 subfamily A member 22* / cytochrome P450 family 4 sub...ENSMUSG0000007859778
Q91WL5 / Cyp4a12a / Cytochrome P450 4A12A / Q02928* / Q5TCH4* / CYP4A11* / CYP4A22* / cytochrome P450 family 4 subfamily A member 22* / cytochrome P450 family 4 subfamily A member 11*ENSMUSG0000006607177
O35728 / Cyp4a14 / Cytochrome P450 4A14 / Q5TCH4* / Q02928* / CYP4A11* / CYP4A22* / cytochrome P450 family 4 subfamily A member 22* / cytochrome P450 family 4 subfamily A member 11*ENSMUSG0000002871571
Cyp4a30b / cytochrome P450, family 4, subfamily a, polypeptide 30b / Q5TCH4* / Q02928* / CYP4A11* / CYP4A22* / cytochrome P450 family 4 subfamily A member 22* / cytochrome P450 family 4 sub...ENSMUSG0000008434669
Cyp4a29 / cytochrome P450, family 4, subfamily a, polypeptide 29 / Q5TCH4* / Q02928* / CYP4A11* / CYP4A22* / cytochrome P450 family 4 subfamily A member 22* / cytochrome P450 family 4 subfa...ENSMUSG0000008313869
Cyp4b1 / Q64462 / Cytochrome P450 4B1 / P13584* / cytochrome P450 family 4 subfamily B member 1*ENSMUSG0000002871352
Cyp4x1 / Q6A152 / Cytochrome P450 4X1 / Q8N118* / cytochrome P450 family 4 subfamily X member 1*ENSMUSG0000004715550
Q99N16 / Cyp4f18 / Leukotriene-B(4) omega-hydroxylase 2 / CYP4F3* / Q08477* / cytochrome P450 family 4 subfamily F member 3*ENSMUSG0000000348445
Cyp4f15 / cytochrome P450, family 4, subfamily f, polypeptide 15ENSMUSG0000007342444
Cyp4f13 / cytochrome P450, family 4, subfamily f, polypeptide 13ENSMUSG0000002405544
Cyp4f40 / cytochrome P450, family 4, subfamily f, polypeptide 40ENSMUSG0000009070044
Cyp4f17 / cytochrome P450, family 4, subfamily f, polypeptide 17ENSMUSG0000009158644
Q9EP75 / Cyp4f14 / Mus musculus cytochrome P450, family 4, subfamily f, polypeptide 14 (Cyp4f14), transcript variant 6, mRNA.ENSMUSG0000002429244
Cyp4f16 / cytochrome P450, family 4, subfamily f, polypeptide 16ENSMUSG0000004844043
Cyp4f39 / cytochrome P450, family 4, subfamily f, polypeptide 39 / Q6NT55* / CYP4F22* / cytochrome P450 family 4 subfamily F member 22*ENSMUSG0000006112642
Cyp4f37 / cytochrome P450, family 4, subfamily f, polypeptide 37ENSMUSG0000006246442
Q9DBW0 / Cyp4v3 / Cytochrome P450 4V2 / CYP4V2* / Q6ZWL3* / cytochrome P450 family 4 subfamily V member 2*ENSMUSG0000007905731


Protein motifs (from Interpro)
Interpro ID Name
 IPR001128  Cytochrome P450
 IPR002401  Cytochrome P450, E-class, group I
 IPR017972  Cytochrome P450, conserved site
 IPR036396  Cytochrome P450 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006631 fatty acid metabolic process TAS
 biological_processGO:0036101 leukotriene B4 catabolic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane ISO
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0008392 arachidonic acid epoxygenase activity ISO
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0018685 alkane 1-monooxygenase activity ISO
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050051 leukotriene-B4 20-monooxygenase activity ISO


Pathways (from Reactome)
Pathway description
Fatty acids
Eicosanoids
Synthesis of Leukotrienes (LT) and Eoxins (EX)
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000231 hypertension "sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ednrbtm1Myks/Ednrbtm1Myks
Genetic Background: involves: 129P2/OlaHsd

 MP:0000676 abnormal water content "more or less than the normal total amount of water retained in the body" [il:Ira Lu, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ednrbtm1Myks/Ednrbtm1Myks
Genetic Background: involves: 129P2/OlaHsd

 MP:0003620 decreased urine output "decreased volume of urine produced and excreted" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Ednrbtm1Myks/Ednrbtm1Myks
Genetic Background: involves: 129P2/OlaHsd

 MP:0004217 salt-sensitive hypertension "sustained high blood pressure that is maintained with a normal or increase in the amount of salt consumed in the diet; blood pressure may return to normotensive with a low salt diet" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ednrbtm1Myks/Ednrbtm1Myks
Genetic Background: involves: 129P2/OlaHsd

 MP:0005618 decreased potassium excretion "less than the normal amount of this alkaline metallic element, the most abundant intracellular ion, voided by the kidneys" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Ednrbtm1Myks/Ednrbtm1Myks
Genetic Background: involves: 129P2/OlaHsd

 MP:0006144 increased systolic blood pressure "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ednrbtm1Myks/Ednrbtm1Myks
Genetic Background: involves: 129P2/OlaHsd

 MP:0010109 abnormal renal sodium reabsorption "any anomaly in the process by which sodium ions are transported out of the renal tubules back into the bloodstream" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ednrbtm1Myks/Ednrbtm1Myks
Genetic Background: involves: 129P2/OlaHsd

 MP:0011442 abnormal renal sodium ion transport "any anomaly in the directed movement of sodium ions (Na+) by the kidney" [GO:0003096]
Show

Allelic Composition: Ednrbtm1Myks/Ednrbtm1Myks
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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