ENSG00000187048


Homo sapiens

Features
Gene ID: ENSG00000187048
  
Biological name :CYP4A11
  
Synonyms : CYP4A11 / cytochrome P450 family 4 subfamily A member 11 / Q02928
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p33
Gene start: 46929177
Gene end: 46941484
  
Corresponding Affymetrix probe sets: 1554837_a_at (Human Genome U133 Plus 2.0 Array)   1554931_at (Human Genome U133 Plus 2.0 Array)   207407_x_at (Human Genome U133 Plus 2.0 Array)   211231_x_at (Human Genome U133 Plus 2.0 Array)   217319_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000476854
Ensembl peptide - ENSP00000476619
Ensembl peptide - ENSP00000476988
Ensembl peptide - ENSP00000477495
Ensembl peptide - ENSP00000311095
Ensembl peptide - ENSP00000360971
Ensembl peptide - ENSP00000360972
Ensembl peptide - ENSP00000476368
NCBI entrez gene - 1579     See in Manteia.
OMIM - 601310
RefSeq - XM_017000465
RefSeq - NM_000778
RefSeq - NM_001319155
RefSeq - XM_005270539
RefSeq - XM_017000464
RefSeq Peptide - NP_001306084
RefSeq Peptide - NP_000769
swissprot - V9GY41
swissprot - V9GYC6
swissprot - V9GYK4
swissprot - V9GYQ2
swissprot - E7EVL8
swissprot - V9GZ77
swissprot - A0A0C4DFV7
swissprot - Q02928
Ensembl - ENSG00000187048
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cyp4t8ENSDARG00000004964Danio rerio
 CYP4A22ENSGALG00000020688Gallus gallus
 CYP4B7ENSGALG00000010469Gallus gallus
 Cyp4a12bENSMUSG00000078597Mus musculus
 Cyp4a29ENSMUSG00000083138Mus musculus
 Cyp4a30bENSMUSG00000084346Mus musculus
 Cyp4a31ENSMUSG00000028712Mus musculus
 Cyp4a32ENSMUSG00000063929Mus musculus
 O35728ENSMUSG00000028715Mus musculus
 O88833ENSMUSG00000066072Mus musculus
 Q91WL5ENSMUSG00000066071Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q5TCH4 / CYP4A22 / cytochrome P450 family 4 subfamily A member 22ENSG0000016236595
CYP4B1 / P13584 / cytochrome P450 family 4 subfamily B member 1ENSG0000014297351
CYP4Z1 / Q86W10 / cytochrome P450 family 4 subfamily Z member 1ENSG0000018616049
CYP4X1 / Q8N118 / cytochrome P450 family 4 subfamily X member 1ENSG0000018637747
CYP4F3 / Q08477 / cytochrome P450 family 4 subfamily F member 3ENSG0000018652946
Q9HBI6 / CYP4F11 / cytochrome P450 family 4 subfamily F member 11ENSG0000017190345
CYP4F2 / P78329 / cytochrome P450 family 4 subfamily F member 2ENSG0000018611545
CYP4F8 / P98187 / cytochrome P450 family 4 subfamily F member 8ENSG0000018652644
Q9HCS2 / CYP4F12 / cytochrome P450 family 4 subfamily F member 12ENSG0000018620444
Q6NT55 / CYP4F22 / cytochrome P450 family 4 subfamily F member 22ENSG0000017195443
CYP4V2 / Q6ZWL3 / cytochrome P450 family 4 subfamily V member 2ENSG0000014547631


Protein motifs (from Interpro)
Interpro ID Name
 IPR001128  Cytochrome P450
 IPR002401  Cytochrome P450, E-class, group I
 IPR002402  Cytochrome P450, E-class, group II
 IPR017972  Cytochrome P450, conserved site
 IPR036396  Cytochrome P450 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001676 long-chain fatty acid metabolic process IDA
 biological_processGO:0003091 renal water homeostasis IEP
 biological_processGO:0003095 pressure natriuresis IEP
 biological_processGO:0006631 fatty acid metabolic process TAS
 biological_processGO:0006691 leukotriene metabolic process IDA
 biological_processGO:0019216 regulation of lipid metabolic process TAS
 biological_processGO:0019369 arachidonic acid metabolic process IDA
 biological_processGO:0019373 epoxygenase P450 pathway IDA
 biological_processGO:0032305 positive regulation of icosanoid secretion IMP
 biological_processGO:0036101 leukotriene B4 catabolic process IEA
 biological_processGO:0055078 sodium ion homeostasis IEP
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0097267 omega-hydroxylase P450 pathway TAS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IDA
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0008392 arachidonic acid epoxygenase activity IDA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0018685 alkane 1-monooxygenase activity TAS
 molecular_functionGO:0019825 oxygen binding TAS
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050051 leukotriene-B4 20-monooxygenase activity IDA


Pathways (from Reactome)
Pathway description
PPARA activates gene expression
Fatty acids
Miscellaneous substrates
Eicosanoids
Synthesis of Leukotrienes (LT) and Eoxins (EX)
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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