ENSG00000186115


Homo sapiens

Features
Gene ID: ENSG00000186115
  
Biological name :CYP4F2
  
Synonyms : CYP4F2 / cytochrome P450 family 4 subfamily F member 2 / P78329
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: p13.12
Gene start: 15878023
Gene end: 15898120
  
Corresponding Affymetrix probe sets: 206514_s_at (Human Genome U133 Plus 2.0 Array)   210452_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000467443
Ensembl peptide - ENSP00000467846
Ensembl peptide - ENSP00000011989
Ensembl peptide - ENSP00000221700
Ensembl peptide - ENSP00000465514
NCBI entrez gene - 8529     See in Manteia.
OMIM - 604426
RefSeq - NM_001082
RefSeq Peptide - NP_001073
swissprot - K7EPM0
swissprot - A0A0A0MQR0
swissprot - P78329
swissprot - K7EQI8
swissprot - K7EK90
Ensembl - ENSG00000186115
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cyp4f3ENSDARG00000053530Danio rerio


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CYP4F3 / Q08477 / cytochrome P450 family 4 subfamily F member 3ENSG0000018652988
Q9HBI6 / CYP4F11 / cytochrome P450 family 4 subfamily F member 11ENSG0000017190387
Q9HCS2 / CYP4F12 / cytochrome P450 family 4 subfamily F member 12ENSG0000018620482
CYP4F8 / P98187 / cytochrome P450 family 4 subfamily F member 8ENSG0000018652681
Q6NT55 / CYP4F22 / cytochrome P450 family 4 subfamily F member 22ENSG0000017195465
Q02928 / CYP4A11 / cytochrome P450 family 4 subfamily A member 11ENSG0000018704845
Q5TCH4 / CYP4A22 / cytochrome P450 family 4 subfamily A member 22ENSG0000016236543
CYP4B1 / P13584 / cytochrome P450 family 4 subfamily B member 1ENSG0000014297342
CYP4X1 / Q8N118 / cytochrome P450 family 4 subfamily X member 1ENSG0000018637740
CYP4Z1 / Q86W10 / cytochrome P450 family 4 subfamily Z member 1ENSG0000018616038
CYP4V2 / Q6ZWL3 / cytochrome P450 family 4 subfamily V member 2ENSG0000014547634


Protein motifs (from Interpro)
Interpro ID Name
 IPR001128  Cytochrome P450
 IPR002401  Cytochrome P450, E-class, group I
 IPR017972  Cytochrome P450, conserved site
 IPR036396  Cytochrome P450 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000038 very long-chain fatty acid metabolic process IDA
 biological_processGO:0001676 long-chain fatty acid metabolic process IDA
 biological_processGO:0003091 renal water homeostasis IEP
 biological_processGO:0003095 pressure natriuresis IEP
 biological_processGO:0006690 icosanoid metabolic process TAS
 biological_processGO:0006691 leukotriene metabolic process TAS
 biological_processGO:0007596 blood coagulation TAS
 biological_processGO:0008217 regulation of blood pressure IMP
 biological_processGO:0017144 drug metabolic process IMP
 biological_processGO:0019369 arachidonic acid metabolic process IDA
 biological_processGO:0019373 epoxygenase P450 pathway IDA
 biological_processGO:0032304 negative regulation of icosanoid secretion IMP
 biological_processGO:0032305 positive regulation of icosanoid secretion IMP
 biological_processGO:0036101 leukotriene B4 catabolic process IDA
 biological_processGO:0042360 vitamin E metabolic process IDA
 biological_processGO:0042361 menaquinone catabolic process IDA
 biological_processGO:0042376 phylloquinone catabolic process IEA
 biological_processGO:0042377 vitamin K catabolic process IDA
 biological_processGO:0055078 sodium ion homeostasis IEP
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0097267 omega-hydroxylase P450 pathway TAS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IDA
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008392 arachidonic acid epoxygenase activity IDA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen IDA
 molecular_functionGO:0018685 alkane 1-monooxygenase activity IDA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050051 leukotriene-B4 20-monooxygenase activity TAS
 molecular_functionGO:0052869 arachidonic acid omega-hydroxylase activity IDA
 molecular_functionGO:0052870 tocopherol omega-hydroxylase activity IEA
 molecular_functionGO:0052871 alpha-tocopherol omega-hydroxylase activity IEA
 molecular_functionGO:0052872 tocotrienol omega-hydroxylase activity IDA
 molecular_functionGO:0097258 20-hydroxy-leukotriene B4 omega oxidase activity TAS
 molecular_functionGO:0097259 20-aldehyde-leukotriene B4 20-monooxygenase activity TAS


Pathways (from Reactome)
Pathway description
Fatty acids
Miscellaneous substrates
Eicosanoids
Synthesis of Leukotrienes (LT) and Eoxins (EX)
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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