ENSG00000186529


Homo sapiens

Features
Gene ID: ENSG00000186529
  
Biological name :CYP4F3
  
Synonyms : CYP4F3 / cytochrome P450 family 4 subfamily F member 3 / Q08477
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: p13.12
Gene start: 15640897
Gene end: 15662825
  
Corresponding Affymetrix probe sets: 206514_s_at (Human Genome U133 Plus 2.0 Array)   206515_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000466988
Ensembl peptide - ENSP00000466395
Ensembl peptide - ENSP00000468105
Ensembl peptide - ENSP00000476546
Ensembl peptide - ENSP00000221307
Ensembl peptide - ENSP00000465394
NCBI entrez gene - 4051     See in Manteia.
OMIM - 601270
RefSeq - XM_017026815
RefSeq - NM_000896
RefSeq - NM_001199208
RefSeq - NM_001199209
RefSeq - XM_005259911
RefSeq - XM_011528014
RefSeq - XM_017026814
RefSeq Peptide - NP_001186137
RefSeq Peptide - NP_001186138
RefSeq Peptide - NP_000887
swissprot - K7EJZ8
swissprot - Q08477
swissprot - V9GYA1
swissprot - A0A024R7I2
swissprot - A0A024R7J8
Ensembl - ENSG00000186529
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cyp4f3ENSDARG00000053530Danio rerio
 Q99N16ENSMUSG00000003484Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CYP4F2 / P78329 / cytochrome P450 family 4 subfamily F member 2ENSG0000018611588
Q9HBI6 / CYP4F11 / cytochrome P450 family 4 subfamily F member 11ENSG0000017190383
Q9HCS2 / CYP4F12 / cytochrome P450 family 4 subfamily F member 12ENSG0000018620478
CYP4F8 / P98187 / cytochrome P450 family 4 subfamily F member 8ENSG0000018652677
Q6NT55 / CYP4F22 / cytochrome P450 family 4 subfamily F member 22ENSG0000017195465
Q02928 / CYP4A11 / cytochrome P450 family 4 subfamily A member 11ENSG0000018704846
Q5TCH4 / CYP4A22 / cytochrome P450 family 4 subfamily A member 22ENSG0000016236544
CYP4B1 / P13584 / cytochrome P450 family 4 subfamily B member 1ENSG0000014297342
CYP4X1 / Q8N118 / cytochrome P450 family 4 subfamily X member 1ENSG0000018637739
CYP4Z1 / Q86W10 / cytochrome P450 family 4 subfamily Z member 1ENSG0000018616037
CYP4V2 / Q6ZWL3 / cytochrome P450 family 4 subfamily V member 2ENSG0000014547632


Protein motifs (from Interpro)
Interpro ID Name
 IPR001128  Cytochrome P450
 IPR002401  Cytochrome P450, E-class, group I
 IPR017972  Cytochrome P450, conserved site
 IPR036396  Cytochrome P450 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006690 icosanoid metabolic process TAS
 biological_processGO:0006691 leukotriene metabolic process TAS
 biological_processGO:0036101 leukotriene B4 catabolic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004497 monooxygenase activity TAS
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0019825 oxygen binding TAS
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050051 leukotriene-B4 20-monooxygenase activity TAS
 molecular_functionGO:0052870 tocopherol omega-hydroxylase activity IEA
 molecular_functionGO:0052871 alpha-tocopherol omega-hydroxylase activity IEA
 molecular_functionGO:0097258 20-hydroxy-leukotriene B4 omega oxidase activity TAS
 molecular_functionGO:0097259 20-aldehyde-leukotriene B4 20-monooxygenase activity TAS


Pathways (from Reactome)
Pathway description
Fatty acids
Miscellaneous substrates
Eicosanoids
Synthesis of Leukotrienes (LT) and Eoxins (EX)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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