ENSMUSG00000028715


Mus musculus

Features
Gene ID: ENSMUSG00000028715
  
Biological name :Cyp4a14
  
Synonyms : Cyp4a14 / Cytochrome P450 4A14 / O35728
  
Possible biological names infered from orthology : CYP4A11 / CYP4A22 / cytochrome P450 family 4 subfamily A member 11 / cytochrome P450 family 4 subfamily A member 22 / Q02928 / Q5TCH4
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D1
Gene start: 115486200
Gene end: 115496142
  
Corresponding Affymetrix probe sets: 10515187 (MoGene1.0st)   1423257_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030487
NCBI entrez gene - 13119     See in Manteia.
MGI - MGI:1096550
RefSeq - XM_017319946
RefSeq - NM_007822
RefSeq - XM_006502724
RefSeq Peptide - NP_031848
swissprot - O35728
Ensembl - ENSMUSG00000028715
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cyp4t8ENSDARG00000004964Danio rerio
 CYP4A22ENSGALG00000020688Gallus gallus
 CYP4B7ENSGALG00000010469Gallus gallus
 Q02928ENSG00000187048Homo sapiens
 Q5TCH4ENSG00000162365Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cyp4a12b / cytochrome P450, family 4, subfamily a, polypeptide 12B / Q5TCH4* / Q02928* / CYP4A11* / CYP4A22* / cytochrome P450 family 4 subfamily A member 22* / cytochrome P450 family 4 sub...ENSMUSG0000007859772
Q91WL5 / Cyp4a12a / Cytochrome P450 4A12A / Q02928* / Q5TCH4* / CYP4A11* / CYP4A22* / cytochrome P450 family 4 subfamily A member 22* / cytochrome P450 family 4 subfamily A member 11*ENSMUSG0000006607171
Cyp4a32 / cytochrome P450, family 4, subfamily a, polypeptide 32 / Q5TCH4* / Q02928* / CYP4A11* / CYP4A22* / cytochrome P450 family 4 subfamily A member 22* / cytochrome P450 family 4 subfa...ENSMUSG0000006392971
O88833 / Cyp4a10 / Cytochrome P450 4A10 / Q5TCH4* / Q02928* / CYP4A22* / CYP4A11* / cytochrome P450 family 4 subfamily A member 11* / cytochrome P450 family 4 subfamily A member 22*ENSMUSG0000006607271
Cyp4a30b / cytochrome P450, family 4, subfamily a, polypeptide 30b / Q5TCH4* / Q02928* / CYP4A11* / CYP4A22* / cytochrome P450 family 4 subfamily A member 22* / cytochrome P450 family 4 sub...ENSMUSG0000008434671
Cyp4a31 / cytochrome P450, family 4, subfamily a, polypeptide 31 / Q5TCH4* / Q02928* / CYP4A11* / CYP4A22* / cytochrome P450 family 4 subfamily A member 22* / cytochrome P450 family 4 subfa...ENSMUSG0000002871270
Cyp4a29 / cytochrome P450, family 4, subfamily a, polypeptide 29 / Q5TCH4* / Q02928* / CYP4A11* / CYP4A22* / cytochrome P450 family 4 subfamily A member 22* / cytochrome P450 family 4 subfa...ENSMUSG0000008313867
Cyp4b1 / Q64462 / Cytochrome P450 4B1 / P13584* / cytochrome P450 family 4 subfamily B member 1*ENSMUSG0000002871352
Cyp4x1 / Q6A152 / Cytochrome P450 4X1 / Q8N118* / cytochrome P450 family 4 subfamily X member 1*ENSMUSG0000004715548
Q9EP75 / Cyp4f14 / Mus musculus cytochrome P450, family 4, subfamily f, polypeptide 14 (Cyp4f14), transcript variant 6, mRNA.ENSMUSG0000002429244
Cyp4f40 / cytochrome P450, family 4, subfamily f, polypeptide 40ENSMUSG0000009070043
Cyp4f13 / cytochrome P450, family 4, subfamily f, polypeptide 13ENSMUSG0000002405543
Cyp4f15 / cytochrome P450, family 4, subfamily f, polypeptide 15ENSMUSG0000007342443
Cyp4f17 / cytochrome P450, family 4, subfamily f, polypeptide 17ENSMUSG0000009158643
Q99N16 / Cyp4f18 / Leukotriene-B(4) omega-hydroxylase 2 / CYP4F3* / Q08477* / cytochrome P450 family 4 subfamily F member 3*ENSMUSG0000000348442
Cyp4f37 / cytochrome P450, family 4, subfamily f, polypeptide 37ENSMUSG0000006246442
Cyp4f16 / cytochrome P450, family 4, subfamily f, polypeptide 16ENSMUSG0000004844042
Cyp4f39 / cytochrome P450, family 4, subfamily f, polypeptide 39 / Q6NT55* / CYP4F22* / cytochrome P450 family 4 subfamily F member 22*ENSMUSG0000006112642
Q9DBW0 / Cyp4v3 / Cytochrome P450 4V2 / CYP4V2* / Q6ZWL3* / cytochrome P450 family 4 subfamily V member 2*ENSMUSG0000007905733


Protein motifs (from Interpro)
Interpro ID Name
 IPR001128  Cytochrome P450
 IPR002401  Cytochrome P450, E-class, group I
 IPR017972  Cytochrome P450, conserved site
 IPR036396  Cytochrome P450 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Fatty acids
Eicosanoids
Synthesis of Leukotrienes (LT) and Eoxins (EX)
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pax2tm1Pgr/Pax2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002842 increased blood pressure "increased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pax2tm1Pgr/Pax2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002843 decreased blood pressure "decreased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pax2tm1Pgr/Pax2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005529 abnormal renal vascular resistance "deviation from the normal force opposing blood flow in the kidney blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Pax2tm1Pgr/Pax2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005531 increased renal vascular resistance "greater than the normal force opposing blood flow in the kidney blood vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Pax2tm1Pgr/Pax2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006143 increased diastolic blood pressure "abnormal increase in the pressure in the arteries between heart beats when the heart is relaxed" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Pax2tm1Pgr/Pax2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006144 increased systolic blood pressure "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Pax2tm1Pgr/Pax2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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