ENSMUSG00000003657


Mus musculus

Features
Gene ID: ENSMUSG00000003657
  
Biological name :Calb2
  
Synonyms : Calb2 / Calretinin / Q08331
  
Possible biological names infered from orthology : calbindin 2 / P22676
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: D3
Gene start: 110137502
Gene end: 110168210
  
Corresponding Affymetrix probe sets: 10581654 (MoGene1.0st)   1451129_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000003754
Ensembl peptide - ENSMUSP00000148680
NCBI entrez gene - 12308     See in Manteia.
MGI - MGI:101914
RefSeq - NM_007586
RefSeq Peptide - NP_031612
swissprot - Q08331
swissprot - Q8CCS7
Ensembl - ENSMUSG00000003657
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 calb2aENSDARG00000041062Danio rerio
 calb2bENSDARG00000036344Danio rerio
 CALB2ENSGALG00000026903Gallus gallus
 CALB2ENSG00000172137Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Calb1 / P12658 / Calbindin / P05937* / calbindin 1*ENSMUSG0000002822256
Scgn / Q91WD9 / Secretagogin / O76038* / secretagogin, EF-hand calcium binding protein*ENSMUSG0000002133734


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site
 IPR029646  Calretinin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0051480 regulation of cytosolic calcium ion concentration IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005921 gap junction IDA
 cellular_componentGO:0043005 neuron projection IBA
 cellular_componentGO:0043195 terminal bouton IEA
 cellular_componentGO:0045202 synapse IBA
 molecular_functionGO:0005509 calcium ion binding IBA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cyp19a1tm1Sih/Cyp19a1tm1Sih
Genetic Background: involves: 129S/SvEv

Allelic Composition: Calb2tm2.1(cre/ERT2)Zjh/Calb2tm2.1(cre/ERT2)Zjh
Genetic Background: involves: C57BL/6 * SJL

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Calb2tm2.1(cre/ERT2)Zjh/Calb2tm2.1(cre/ERT2)Zjh
Genetic Background: involves: C57BL/6 * SJL

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nkx3-1tm4(cre/ERT2)Mms/Nkx3-1+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Calb2tm2.1(cre/ERT2)Zjh/Calb2+
Genetic Background: involves: C57BL/6 * SJL

 MP:0002207 abnormal long term potentiation "alterations in a persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cyp19a1tm1Sih/Cyp19a1tm1Sih
Genetic Background: involves: 129S/SvEv

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cyp19a1tm1Sih/Cyp19a1tm1Sih
Genetic Background: involves: 129S/SvEv

Allelic Composition: Calb2tm2.1(cre/ERT2)Zjh/Calb2tm2.1(cre/ERT2)Zjh
Genetic Background: involves: C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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