ENSMUSG00000004268


Mus musculus

Features
Gene ID: ENSMUSG00000004268
  
Biological name :Emg1
  
Synonyms : Emg1 / O35130 / Ribosomal RNA small subunit methyltransferase NEP1
  
Possible biological names infered from orthology : EMG1, N1-specific pseudouridine methyltransferase / Q92979
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: F2
Gene start: 124704085
Gene end: 124712178
  
Corresponding Affymetrix probe sets: 10547758 (MoGene1.0st)   1416393_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000144730
Ensembl peptide - ENSMUSP00000004379
NCBI entrez gene - 14791     See in Manteia.
MGI - MGI:1315195
RefSeq - NM_013536
RefSeq Peptide - NP_038564
swissprot - A0A0N4SUL6
swissprot - O35130
swissprot - Q542P8
Ensembl - ENSMUSG00000004268
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 emg1ENSDARG00000056914Danio rerio
 EMG1ENSGALG00000014568Gallus gallus
 EMG1ENSG00000126749Homo sapiens
 EMG1ENSG00000268439Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR005304  Ribosomal biogenesis, methyltransferase, EMG1/NEP1
 IPR029028  Alpha/beta knot methyltransferases


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
 biological_processGO:0001824 blastocyst development IMP
 biological_processGO:0006364 rRNA processing IEA
 biological_processGO:0017126 nucleologenesis IMP
 biological_processGO:0032259 methylation IEA
 biological_processGO:0042254 ribosome biogenesis IEA
 biological_processGO:0070475 rRNA base methylation IBA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005730 nucleolus IBA
 cellular_componentGO:0032040 small-subunit processome IBA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019843 rRNA binding IEA
 molecular_functionGO:0070037 rRNA (pseudouridine) methyltransferase activity ISO


Pathways (from Reactome)
Pathway description
Major pathway of rRNA processing in the nucleolus and cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Ptentm1Hwu

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Ptentm1Hwu

 MP:0000928 incomplete cephalic closure "arrest of the fusion of the cephalic neural folds" [J:12622]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Ptentm1Hwu

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Ptentm1Hwu

 MP:0000930 wavy neural tube "undulations in the embryonic neural tube" [J:37888]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Ptentm1Hwu

 MP:0000934 abnormal telencephalon development "malformed or incomplete differentiation of the anterior division of the embryonic prosencephalon " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Ptentm1Hwu

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Ptentm1Hwu

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Ptentm1Hwu

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Terf2iptm1.1Blas/Terf2iptm1.1Blas
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Emg1tm1Hdin/Emg1tm1Hdin,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S * 129S2/SvPas * 129X1/SvJ * CD-1 * ICR

 MP:0002663 failure to form blastocele "developmental anomaly resulting in the absence of the cavity in the blastula of the developing embryo" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:19904]
Show

Allelic Composition: Terf2iptm1.1Blas/Terf2iptm1.1Blas
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Emg1tm1Hdin/Emg1tm1Hdin,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S * 129S2/SvPas * 129X1/SvJ * CD-1 * ICR

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Ptentm1Hwu

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Ptentm1Hwu

 MP:0004964 absent inner cell mass "absence of the cells of the blastocyst that develop into the body of the embryo" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Terf2iptm1.1Blas/Terf2iptm1.1Blas
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Ptentm1Hwu

 MP:0008830 abnormal nucleolus morphology "any structural anomaly of the small rounded nuclear substructure that produces ribonucleoprotein" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Terf2iptm1.1Blas/Terf2iptm1.1Blas
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL

 MP:0009781 abnormal preimplantation embryo development "an anomaly in the developmental progress of an embryo from 2 cell to blastocyst affecting the viability or number of embryos" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Terf2iptm1.1Blas/Terf2iptm1.1Blas
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Emg1tm1Hdin/Emg1tm1Hdin,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S * 129S2/SvPas * 129X1/SvJ * CD-1 * ICR

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Terf2iptm1.1Blas/Terf2iptm1.1Blas
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Ptentm1Hwu

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr