ENSMUSG00000005107


Mus musculus

Features
Gene ID: ENSMUSG00000005107
  
Biological name :Slc2a9
  
Synonyms : Slc2a9 / solute carrier family 2 (facilitated glucose transporter), member 9
  
Possible biological names infered from orthology : Q9NRM0 / solute carrier family 2 member 9
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: B3
Gene start: 38349273
Gene end: 38503143
  
Corresponding Affymetrix probe sets: 10529671 (MoGene1.0st)   1426568_at (Mouse Genome 430 2.0 Array)   1440873_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118430
Ensembl peptide - ENSMUSP00000117390
Ensembl peptide - ENSMUSP00000119586
Ensembl peptide - ENSMUSP00000144374
Ensembl peptide - ENSMUSP00000122723
Ensembl peptide - ENSMUSP00000005238
Ensembl peptide - ENSMUSP00000063352
Ensembl peptide - ENSMUSP00000066872
Ensembl peptide - ENSMUSP00000116354
NCBI entrez gene - 117591     See in Manteia.
MGI - MGI:2152844
RefSeq - XM_011240691
RefSeq - NM_001102414
RefSeq - NM_001102415
RefSeq - NM_145559
RefSeq - XM_006503683
RefSeq - XM_006503684
RefSeq - XM_006503685
RefSeq - XM_006503686
RefSeq - XM_006503687
RefSeq - XM_011240688
RefSeq - XM_011240689
RefSeq - XM_011240690
RefSeq - NM_001012363
RefSeq Peptide - NP_001012363
RefSeq Peptide - NP_001095884
RefSeq Peptide - NP_001095885
RefSeq Peptide - NP_663534
swissprot - Q7TSK9
swissprot - D6REU9
swissprot - A0A0J9YUW8
swissprot - Q99JJ2
swissprot - D3Z1X2
swissprot - B9EHN5
swissprot - Q3T9X0
Ensembl - ENSMUSG00000005107
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01086812.1ENSDARG00000117001Danio rerio
 SLC2A9ENSGALG00000014971Gallus gallus
 Q9NRM0ENSG00000109667Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Slc2a7 / solute carrier family 2 (facilitated glucose transporter), member 7 / Q6PXP3* / solute carrier family 2 member 7*ENSMUSG0000006206441
Q9WV38 / Slc2a5 / solute carrier family 2 (facilitated glucose transporter), member 5 / P22732* / solute carrier family 2 member 5*ENSMUSG0000002897641
P17809 / Slc2a1 / solute carrier family 2 (facilitated glucose transporter), member 1 / P11166* / solute carrier family 2 member 1*ENSMUSG0000002864536
P14142 / Slc2a4 / solute carrier family 2 (facilitated glucose transporter), member 4 / P14672* / solute carrier family 2 member 4*ENSMUSG0000001856635
P32037 / Slc2a3 / solute carrier family 2 (facilitated glucose transporter), member 3 / P11169* / Q8TDB8* / SLC2A14* / solute carrier family 2 member 3* / solute carrier family 2 member 14*ENSMUSG0000000315335
P14246 / Slc2a2 / solute carrier family 2 (facilitated glucose transporter), member 2 / P11168* / solute carrier family 2 member 2*ENSMUSG0000002769030


Protein motifs (from Interpro)
Interpro ID Name
 IPR003663  Sugar/inositol transporter
 IPR005828  Major facilitator, sugar transporter-like
 IPR005829  Sugar transporter, conserved site
 IPR020846  Major facilitator superfamily domain
 IPR036259  MFS transporter superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008643 carbohydrate transport IEA
 biological_processGO:0015747 urate transport IEA
 biological_processGO:0046415 urate metabolic process ISO
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:1904659 glucose transmembrane transport IEA
 cellular_componentGO:0005635 nuclear envelope IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005215 transporter activity IEA
 molecular_functionGO:0005355 glucose transmembrane transporter activity IDA
 molecular_functionGO:0015143 urate transmembrane transporter activity ISO
 molecular_functionGO:0022857 transmembrane transporter activity IEA


Pathways (from Reactome)
Pathway description
Cellular hexose transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000231 hypertension "sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ddr2tm1.1(cre/Esr1*)Rcow/Ddr2tm1.1(cre/Esr1*)Rcow
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000519 hydronephrosis "dilation of the pelvis and calices of one or both kidneys" [J:56641]
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Allelic Composition: St14tm2Bug/St14tm3Bug,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA

 MP:0000522 cysts in kidney cortex "abnormal membranous sacs appearing in the renal lobules, tubules and glomeruli" [J:50844]
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Allelic Composition: St14tm2Bug/St14tm3Bug,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: St14tm2Bug/St14tm3Bug,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA

 MP:0001426 polydipsia "excessive thirst that is relatively prolonged" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: St14tm2Bug/St14tm3Bug,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Ddr2tm1.1(cre/Esr1*)Rcow/Ddr2tm1.1(cre/Esr1*)Rcow
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Ddr2tm1.1(cre/Esr1*)Rcow/Ddr2tm1.1(cre/Esr1*)Rcow
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: St14tm2Bug/St14tm3Bug,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA

Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Slc2a9tm1.1Thor/Slc2a9tm1.1Thor
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6N

 MP:0001859 kidney inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: St14tm2Bug/St14tm3Bug,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ddr2tm1.1(cre/Esr1*)Rcow/Ddr2tm1.1(cre/Esr1*)Rcow
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002626 increased heart rate "greater than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ddr2tm1.1(cre/Esr1*)Rcow/Ddr2tm1.1(cre/Esr1*)Rcow
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ddr2tm1.1(cre/Esr1*)Rcow/Ddr2tm1.1(cre/Esr1*)Rcow
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: St14tm2Bug/St14tm3Bug,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA

 MP:0002708 kidney stones "calculi occurring in the kidney" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: St14tm2Bug/St14tm3Bug,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA

 MP:0002901 hyperphosphaturia "an increase of excretion of phosphates in the urine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Slc2a9tm1.1Thor/Slc2a9tm1.1Thor
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6N

Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Slc2a9tm1.1Thor/Slc2a9+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6N

 MP:0002988 decreased urine osmolarity "reduction in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000]
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Allelic Composition: St14tm2Bug/St14tm3Bug,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA

Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Slc2a9tm1.1Thor/Slc2a9tm1.1Thor
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6N

 MP:0003215 renal interstitial fibrosis "formation of fibrous tissue within the interstices of the kidney as a result of repair or a reactive process" [RGD:Rat Genome Database submission]
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Allelic Composition: St14tm2Bug/St14tm3Bug,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA

 MP:0003333 liver fibrosis "invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Ddr2tm1.1(cre/Esr1*)Rcow/Ddr2tm1.1(cre/Esr1*)Rcow
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003868 abnormal feces composition "increase or decrease in the amount of compunds normally found in the feces (fat, protein etc) or presence of material not normally seen in the feces" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ddr2tm1.1(cre/Esr1*)Rcow/Ddr2tm1.1(cre/Esr1*)Rcow
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003949 abnormal circulating lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ddr2tm1.1(cre/Esr1*)Rcow/Ddr2tm1.1(cre/Esr1*)Rcow
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004889 increased energy expenditure "increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ddr2tm1.1(cre/Esr1*)Rcow/Ddr2tm1.1(cre/Esr1*)Rcow
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ddr2tm1.1(cre/Esr1*)Rcow/Ddr2tm1.1(cre/Esr1*)Rcow
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005266 abnormal metabolism "anomalous chemical and physical changes occurring in tissue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ddr2tm1.1(cre/Esr1*)Rcow/Ddr2tm1.1(cre/Esr1*)Rcow
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ddr2tm1.1(cre/Esr1*)Rcow/Ddr2tm1.1(cre/Esr1*)Rcow
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ddr2tm1.1(cre/Esr1*)Rcow/Ddr2tm1.1(cre/Esr1*)Rcow
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005458 increased percent body fat "more fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ddr2tm1.1(cre/Esr1*)Rcow/Ddr2tm1.1(cre/Esr1*)Rcow
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: St14tm2Bug/St14tm3Bug,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA

 MP:0005619 increased potassium excretion "greater than the normal amount of this alkaline metallic element, the most abundant intracellular ion, voided by the kidneys" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: St14tm2Bug/St14tm3Bug,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA

Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Slc2a9tm1.1Thor/Slc2a9tm1.1Thor
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6N

 MP:0006316 increased urine sodium level "higher than normal concentration of sodium in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: St14tm2Bug/St14tm3Bug,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA

Allelic Composition: Slc2a9tm1.2Thor/Slc2a9+
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0008821 increased blood uric acid level "greater concentration in the blood of the final oxidation product of purine catabolism in humans and primates, but which in rodents and most other mammals is normally is further oxidized by uricase to allantoin that is excreted in the urine" [MESH:D03.132.960.877, MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: St14tm2Bug/St14tm3Bug,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA

Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Slc2a9tm1.1Thor/Slc2a9tm1.1Thor
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6N

Allelic Composition: Slc2a9tm1Khm/Slc2a9tm1Khm,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

 MP:0008882 abnormal enterocyte physiology "any functional anomaly of the epithelial cells that have an apical plasma membrane folded into microvilli to provide ample surface for the absorption of nutrients from the intestinal lumen" [CL:0000584, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc2a9tm1Khm/Slc2a9tm1Khm,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

 MP:0008965 increased basal metabolism "increase in heat production of an organism at the lowest level of cell chemistry in an inactive, awake, and fasting state" [MESH:E01.370.374.750.100]
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Allelic Composition: Slc2a9tm1Khm/Slc2a9tm1Khm,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

 MP:0009350 decreased urine pH "increased urine acidity" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: St14tm2Bug/St14tm3Bug,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA

Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Slc2a9tm1.1Thor/Slc2a9tm1.1Thor
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6N

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc2a9tm1Khm/Slc2a9tm1Khm,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

 MP:0009810 increased urine uric acid level "greater concentration in the urine of the final oxidation product of purine catabolism in humans and primates, but which in rodents and most other mammals is normally is further oxidized by uricase to allantoin that is excreted in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc2a9tm1Khm/Slc2a9tm1Khm,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

 MP:0010092 increased circulating magnesium level "an elevation in the blood concentration of magnesium" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: St14tm2Bug/St14tm3Bug,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA

Allelic Composition: Slc2a9tm1.2Thor/Slc2a9+
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0010107 abnormal renal reabsorption "any anomaly in the two-step process beginning with the active or passive extraction of substances (such as water, glucose, oligopeptides, amino acids, sodium (Na+) and other ions) from the renal tubule fluid into the renal interstitium, and the subsequent transport of these substances out of the renal interstitium back into the bloodstream; reabsorption begins in the proximal convoluted tubules and continues in the loop of Henle, distal convoluted tubules, and collecting tubules" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: St14tm2Bug/St14tm3Bug,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA

 MP:0010359 increased liver free fatty acids level "elevated liver concentrations of the fatty acids which occur in plasma as a result of lipolysis in adipose tissue or when plasma triacyglycerols are taken into tissues" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Slc2a9tm1Khm/Slc2a9tm1Khm,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

 MP:0010379 decreased respiratory quotient "reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc2a9tm1Khm/Slc2a9tm1Khm,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: St14tm2Bug/St14tm3Bug,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA

 MP:0011346 renal tubule atrophy "acquired diminution of the size of the loops of Henle, the proximal convoluted tubule or the distal convoluted tubule associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]
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Allelic Composition: St14tm2Bug/St14tm3Bug,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA

 MP:0011405 tubulointerstitial nephritis "diffuse or local inflammation and edema of the interstitial tissue of the kidney, including the renal tubules; usually secondary to drug sensitization, systemic infection, graft rejection, or autoimmune disease" [MGI:anna]
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Allelic Composition: St14tm2Bug/St14tm3Bug,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA

 MP:0011423 kidney cortex atrophy "acquired diminution of the size of the outer portion of the kidney located between the renal capsule and the renal medulla, associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]
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Allelic Composition: St14tm2Bug/St14tm3Bug,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA

 MP:0011435 increased urine magnesium level "higher than normal amount of magnesium in the urine" [MGI:anna]
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Allelic Composition: St14tm2Bug/St14tm3Bug,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA

Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Slc2a9tm1.1Thor/Slc2a9tm1.1Thor
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6N

Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Slc2a9tm1.1Thor/Slc2a9+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6N

 MP:0011537 uraturia "passage of an increased amount of any salt or ester of uric acid (urate) in the urine" [MGI:anna]
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Allelic Composition: St14tm2Bug/St14tm3Bug,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA

Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Slc2a9tm1.1Thor/Slc2a9tm1.1Thor
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6N

 MP:0011925 abnormal heart echocardiography feature "any anomaly in echocardiographic representation of systolic and diastolic function, ventricular compliance, valvular function, or interventricular septum features" [MPD:Molly]
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Allelic Composition: Slc2a9tm1Khm/Slc2a9tm1Khm,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

 MP:0014142 increased body fat mass "increased physical bulk or volume of fat in the whole body" [MGI:csmith]
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Allelic Composition: Slc2a9tm1Khm/Slc2a9tm1Khm,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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