ENSMUSG00000018566


Mus musculus

Features
Gene ID: ENSMUSG00000018566
  
Biological name :Slc2a4
  
Synonyms : P14142 / Slc2a4 / solute carrier family 2 (facilitated glucose transporter), member 4
  
Possible biological names infered from orthology : P14672 / solute carrier family 2 member 4
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B3
Gene start: 69942539
Gene end: 69948188
  
Corresponding Affymetrix probe sets: 10387743 (MoGene1.0st)   1415958_at (Mouse Genome 430 2.0 Array)   1415959_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000137463
Ensembl peptide - ENSMUSP00000136806
Ensembl peptide - ENSMUSP00000137092
Ensembl peptide - ENSMUSP00000018710
Ensembl peptide - ENSMUSP00000136455
Ensembl peptide - ENSMUSP00000136504
Ensembl peptide - ENSMUSP00000136726
NCBI entrez gene - 20528     See in Manteia.
MGI - MGI:95758
RefSeq - XM_006532655
RefSeq - NM_009204
RefSeq - XM_006532653
RefSeq - XM_006532654
RefSeq Peptide - NP_033230
swissprot - J3QK17
swissprot - A0A0G2JDD0
swissprot - P14142
swissprot - J3QMU2
swissprot - J3QMX9
swissprot - J3QP46
swissprot - J3QNF4
Ensembl - ENSMUSG00000018566
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 P14672ENSG00000181856Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P17809 / Slc2a1 / solute carrier family 2 (facilitated glucose transporter), member 1 / P11166* / solute carrier family 2 member 1*ENSMUSG0000002864564
P32037 / Slc2a3 / solute carrier family 2 (facilitated glucose transporter), member 3 / P11169* / Q8TDB8* / SLC2A14* / solute carrier family 2 member 3* / solute carrier family 2 member 14*ENSMUSG0000000315355
P14246 / Slc2a2 / solute carrier family 2 (facilitated glucose transporter), member 2 / P11168* / solute carrier family 2 member 2*ENSMUSG0000002769053
Slc2a7 / solute carrier family 2 (facilitated glucose transporter), member 7 / Q6PXP3* / solute carrier family 2 member 7*ENSMUSG0000006206441
Q9WV38 / Slc2a5 / solute carrier family 2 (facilitated glucose transporter), member 5 / P22732* / solute carrier family 2 member 5*ENSMUSG0000002897639
Slc2a9 / solute carrier family 2 (facilitated glucose transporter), member 9 / Q9NRM0* / solute carrier family 2 member 9*ENSMUSG0000000510737


Protein motifs (from Interpro)
Interpro ID Name
 IPR002441  Glucose transporter, type 4 (GLUT4)
 IPR003663  Sugar/inositol transporter
 IPR005828  Major facilitator, sugar transporter-like
 IPR005829  Sugar transporter, conserved site
 IPR020846  Major facilitator superfamily domain
 IPR036259  MFS transporter superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008643 carbohydrate transport IEA
 biological_processGO:0010021 amylopectin biosynthetic process IDA
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0042593 glucose homeostasis IEA
 biological_processGO:0044381 glucose import in response to insulin stimulus IDA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0046323 glucose import IEA
 biological_processGO:0050873 brown fat cell differentiation IDA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IDA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0071470 cellular response to osmotic stress IDA
 biological_processGO:1904659 glucose transmembrane transport IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005771 multivesicular body IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0005905 clathrin-coated pit IEA
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0012505 endomembrane system IEA
 cellular_componentGO:0012506 vesicle membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030136 clathrin-coated vesicle IEA
 cellular_componentGO:0030140 trans-Golgi network transport vesicle IDA
 cellular_componentGO:0030315 T-tubule IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IDA
 cellular_componentGO:0031982 vesicle IEA
 cellular_componentGO:0032593 insulin-responsive compartment IEA
 cellular_componentGO:0042383 sarcolemma IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0045121 membrane raft IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0070062 extracellular exosome IDA
 molecular_functionGO:0005215 transporter activity IEA
 molecular_functionGO:0005355 glucose transmembrane transporter activity IEA
 molecular_functionGO:0005360 insulin-responsive glucose:proton symporter activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0022857 transmembrane transporter activity IEA
 molecular_functionGO:0055056 D-glucose transmembrane transporter activity IEA


Pathways (from Reactome)
Pathway description
Cellular hexose transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000188 abnormal circulating glucose level "anomalous concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptger4tm1Bhk/Ptger4tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000231 hypertension "sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Slc2a4tm1Mch/Slc2a4+
Genetic Background: involves: 129/Sv * C57BL/6J * CD-1 * SJL

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Edaraddcr/Edaraddcr
Genetic Background: involves: C57BL/6 * C3H

 MP:0000343 altered response to myocardial infarction "change in the physiological response to necrosis of the cardiac tissue, often resulting from the sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Myhca-cre)1Abel/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Edaraddcr/Edaraddcr
Genetic Background: involves: C57BL/6 * C3H

Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Edaraddcr/Edaraddcr
Genetic Background: involves: C57BL/6 * C3H

Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Myhca-cre)1Abel/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Slc2a4tm1Mch/Slc2a4+
Genetic Background: involves: 129/Sv * C57BL/6J * CD-1 * SJL

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ptger4tm1Bhk/Ptger4tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Myhca-cre)1Abel/?
Genetic Background: involves: 129S4/SvJae * FVB

Allelic Composition: Slc2a4tm1Mch/Slc2a4tm1Mch
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Slc2a4tm1Mch/Slc2a4+
Genetic Background: involves: 129/Sv * C57BL/6J * CD-1 * SJL

Allelic Composition: Slc2a4tm1Mch/Slc2a4tm1Mch
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Slc2a4tm1Jdz/Slc2a4tm1Jdz,Tg(ACTA1-cre)1Jdz/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0001669 abnormal glucose absorption "anomalous ability of the body to take in this major monosaccharide, a 6-carbon sugar" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S4/SvJae * FVB

Allelic Composition: Slc2a4tm1Abel/Slc2a4+,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S4/SvJae * FVB

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptger4tm1Bhk/Ptger4tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0001853 heart inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the heart" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc2a4tm1Mch/Slc2a4+
Genetic Background: involves: 129/Sv * C57BL/6J * CD-1 * SJL

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Edaraddcr/Edaraddcr
Genetic Background: involves: C57BL/6 * C3H

Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Fabp4-cre)1Abel/?
Genetic Background: involves: 129S4/SvJae * FVB

Allelic Composition: Slc2a4tm1Mch/Slc2a4+
Genetic Background: involves: 129/Sv * C57BL/6J * CD-1 * SJL

Allelic Composition: Slc2a4tm1Mch/Slc2a4tm1Mch
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S4/SvJae * FVB

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ptger4tm1Bhk/Ptger4tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Slc2a4tm1Mch/Slc2a4+
Genetic Background: involves: 129/Sv * C57BL/6J * CD-1 * SJL

Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S4/SvJae * FVB

Allelic Composition: Slc2a4tm1Jdz/Slc2a4tm1Jdz
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Slc2a4tm1Jdz/Slc2a4tm1Jdz,Tg(ACTA1-cre)1Jdz/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptger4tm1Bhk/Ptger4tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptger4tm1Bhk/Ptger4tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Fabp4-cre)1Abel/?
Genetic Background: involves: 129S4/SvJae * FVB

Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S4/SvJae * FVB

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Slc2a4tm1Mch/Slc2a4+
Genetic Background: involves: 129/Sv * C57BL/6J * CD-1 * SJL

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptger4tm1Bhk/Ptger4tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Pdx1tm2Cvw/Pdx1+,Slc2a4tm1Mch/Slc2a4+
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6 * SJL

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Ptger4tm1Bhk/Ptger4tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Myhca-cre)1Abel/?
Genetic Background: involves: 129S4/SvJae * FVB

Allelic Composition: Slc2a4tm1Jdz/Slc2a4tm1Jdz
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Slc2a4tm1Jdz/Slc2a4tm1Jdz,Tg(ACTA1-cre)1Jdz/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0002837 dystrophic cardiac calcinosis "a condition characterized by the localized deposition of calcium salts in the heart; often occuring in association with inflammation or atherosclerotic lesions and other pathological states" [J:76777, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc2a4tm1Mch/Slc2a4+
Genetic Background: involves: 129/Sv * C57BL/6J * CD-1 * SJL

 MP:0002841 impaired skeletal muscle contractility "inability or reduced ability of the skeletal muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Slc2a4tm1Mch/Slc2a4tm1Mch
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J * SJL

 MP:0002953 thick ventricular wall "increased depth of the cardiac wall of the heart ventricles" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
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Allelic Composition: Slc2a4tm1Mch/Slc2a4tm1Mch
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Slc2a4tm1Jdz/Slc2a4tm1Jdz,Tg(ACTA1-cre)1Jdz/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0003058 increased insulin secretion "greater than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Pdx1tm2Cvw/Pdx1+
Genetic Background: involves: 129/Sv * Black Swiss

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Pdx1tm2Cvw/Pdx1+,Slc2a4tm1Mch/Slc2a4+
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6 * SJL

 MP:0003458 decreased circulating ketone body level "less than the normal amount of acetoacetate, 3-hydroxybutyrate and acteone in the blood; produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ptger4tm1Bhk/Ptger4tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0003633 abnormal nervous system physiology 
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Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Myhca-cre)1Abel/?
Genetic Background: involves: 129S4/SvJae * FVB

 MP:0003646 muscle fatigue "increased muscle exhaustion or increased susceptibility to muscle exhaustion" [J:96306]
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Allelic Composition: Slc2a4tm1Mch/Slc2a4tm1Mch
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J * SJL

 MP:0003822 decreased left ventricle systolic pressure "decrease in the pressure in the left ventricle as the heart contracts and pumps blood into the arteries" [RGD:Rat Genome Database submission]
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Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Myhca-cre)1Abel/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0004819 decreased skeletal muscle mass "reduction in the physical bulk, or total amount of matter contained within skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc2a4tm1Mch/Slc2a4tm1Mch
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J * SJL

 MP:0005282 decreased fatty acid level "less than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005291 abnormal glucose tolerance "deviation from the normal response to oral consumption or intravenous injection of specified amounts of glucose; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Edaraddcr/Edaraddcr
Genetic Background: involves: C57BL/6 * C3H

Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Fabp4-cre)1Abel/?
Genetic Background: involves: 129S4/SvJae * FVB

Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pdx1tm2Cvw/Pdx1+
Genetic Background: involves: 129/Sv * Black Swiss

Allelic Composition: Pdx1tm2Cvw/Pdx1+,Slc2a4tm1Mch/Slc2a4+
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6 * SJL

 MP:0005318 decreased triglyceride level "lower than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Edaraddcr/Edaraddcr
Genetic Background: involves: C57BL/6 * C3H

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ptger4tm1Bhk/Ptger4tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Fabp4-cre)1Abel/?
Genetic Background: involves: 129S4/SvJae * FVB

Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Slc2a4tm1Mch/Slc2a4+
Genetic Background: involves: 129/Sv * C57BL/6J * CD-1 * SJL

 MP:0005438 abnormal glycogen homeostasis "abnormal processing and or utilization of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Fabp4-cre)1Abel/?
Genetic Background: involves: 129S4/SvJae * FVB

Allelic Composition: Slc2a4tm1Mch/Slc2a4+
Genetic Background: involves: 129/Sv * C57BL/6J * CD-1 * SJL

 MP:0005439 decreased glycogen level "less than the normal concentration of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Slc2a4tm1Mch/Slc2a4tm1Mch
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J * SJL

 MP:0005440 increased glycogen level "greater than the normal concentration of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Myhca-cre)1Abel/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0005491 islet cell hyperplasia "increased numbers cells within the structures that are scattered throughout the pancreas and comprise its endocrine portion" [J:48446, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pdx1tm2Cvw/Pdx1+
Genetic Background: involves: 129/Sv * Black Swiss

Allelic Composition: Pdx1tm2Cvw/Pdx1+,Slc2a4tm1Mch/Slc2a4+
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6 * SJL

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S4/SvJae * FVB

Allelic Composition: Slc2a4tm1Jdz/Slc2a4tm1Jdz
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Slc2a4tm1Jdz/Slc2a4tm1Jdz,Tg(ACTA1-cre)1Jdz/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Pdx1tm2Cvw/Pdx1+,Slc2a4tm1Mch/Slc2a4+
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6 * SJL

 MP:0005608 cardiac interstitial fibrosis "formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Slc2a4tm1Mch/Slc2a4tm1Mch
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Slc2a4tm1Jdz/Slc2a4tm1Jdz,Tg(ACTA1-cre)1Jdz/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0006085 myocardial necrosis "pathological cell death of the cardiac muscle cells, usually due to irreversible damage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92722]
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Allelic Composition: Slc2a4tm1Mch/Slc2a4+
Genetic Background: involves: 129/Sv * C57BL/6J * CD-1 * SJL

 MP:0006086 decreased body mass index "less than normal average of a measure of weight for height " [ncbi:NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Slc2a4tm1Mch/Slc2a4tm1Mch
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J * SJL

 MP:0006094 adipocyte hypertrophy "increase in the size of fat cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:90802]
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Allelic Composition: Slc2a4tm1Mch/Slc2a4+
Genetic Background: involves: 129/Sv * C57BL/6J * CD-1 * SJL

 MP:0009283 decreased gonadal fat pad weight "less than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptger4tm1Bhk/Ptger4tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0009409 abnormal skeletal muscle fiber type ratio "deviation from the standard ratios of fiber types in a given skeletal muscle compared to control samples" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc2a4tm1Mch/Slc2a4tm1Mch
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J * SJL

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptger4tm1Bhk/Ptger4tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0010400 increased liver glycogen level "greater than the normal concentration of a readily converted carbohydrate reserve in liver" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0030016 increased adipocyte glucose uptake "increased ability of adipocytes to take in glucose" [MGI:anna]
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Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S4/SvJae * FVB

Allelic Composition: Slc2a4tm1Jdz/Slc2a4tm1Jdz,Tg(ACTA1-cre)1Jdz/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0030017 decreased adipocyte glucose uptake "reduced ability of adipocytes to take in glucose" [MGI:anna]
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Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S4/SvJae * FVB

Allelic Composition: Slc2a4tm1Jdz/Slc2a4tm1Jdz
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Slc2a4tm1Jdz/Slc2a4tm1Jdz,Tg(ACTA1-cre)1Jdz/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0030018 increased cardiac cell glucose uptake "increased ability of the cells of the heart to take in glucose" [MGI:anna]
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Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Myhca-cre)1Abel/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

Allelic Composition: Slc2a4tm1Jdz/Slc2a4tm1Jdz,Tg(ACTA1-cre)1Jdz/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0030020 decreased cardiac cell glucose uptake "reduced ability of the cells of the heart to take in glucose" [MGI:anna]
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Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Myhca-cre)1Abel/?
Genetic Background: involves: 129S4/SvJae * FVB

Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Myhca-cre)1Abel/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0030021 increased muscle cell glucose uptake "increased ability of muscle cells to take in glucose" [MGI:anna]
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Allelic Composition: Slc2a4tm1Jdz/Slc2a4tm1Jdz,Tg(ACTA1-cre)1Jdz/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0030022 decreased muscle cell glucose uptake "reduced ability of muscle cells to take in glucose" [MGI:anna]
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Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Slc2a4tm1Mch/Slc2a4+
Genetic Background: involves: 129/Sv * C57BL/6J * CD-1 * SJL

Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S4/SvJae * FVB

Allelic Composition: Slc2a4tm1Abel/Slc2a4+,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S4/SvJae * FVB

Allelic Composition: Slc2a4tm1Jdz/Slc2a4tm1Jdz
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Slc2a4tm1Jdz/Slc2a4tm1Jdz,Tg(ACTA1-cre)1Jdz/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000018566 P14142 / Slc2a4 / solute carrier family 2 (facilitated glucose transporter), member 4 / P14672* / solute carrier family 2 member 4*  / complex
 ENSMUSG00000025142 Q8VBT9 / Aspscr1 / Tether containing UBX domain for GLUT4 / Q9BZE9* / ASPSCR1, UBX domain containing tether for SLC2A4*  / complex






 

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