ENSG00000181856


Homo sapiens

Features
Gene ID: ENSG00000181856
  
Biological name :SLC2A4
  
Synonyms : P14672 / SLC2A4 / solute carrier family 2 member 4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: p13.1
Gene start: 7281667
Gene end: 7288257
  
Corresponding Affymetrix probe sets: 206603_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000461086
Ensembl peptide - ENSP00000320935
Ensembl peptide - ENSP00000396887
Ensembl peptide - ENSP00000459056
Ensembl peptide - ENSP00000459864
NCBI entrez gene - 6517     See in Manteia.
OMIM - 138190
RefSeq - NM_001042
RefSeq Peptide - NP_001033
swissprot - F5H081
swissprot - I3L1S2
swissprot - I3L2R4
swissprot - P14672
Ensembl - ENSG00000181856
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 P14142ENSMUSG00000018566Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P11166 / SLC2A1 / solute carrier family 2 member 1ENSG0000011739463
P11169 / SLC2A3 / solute carrier family 2 member 3ENSG0000005980456
Q8TDB8 / SLC2A14 / solute carrier family 2 member 14ENSG0000017326255
P11168 / SLC2A2 / solute carrier family 2 member 2ENSG0000016358153
P22732 / SLC2A5 / solute carrier family 2 member 5ENSG0000014258341
Q6PXP3 / SLC2A7 / solute carrier family 2 member 7ENSG0000019724139
Q9NRM0 / SLC2A9 / solute carrier family 2 member 9ENSG0000010966736
Q9BYW1 / SLC2A11 / solute carrier family 2 member 11ENSG0000013346030


Protein motifs (from Interpro)
Interpro ID Name
 IPR002441  Glucose transporter, type 4 (GLUT4)
 IPR003663  Sugar/inositol transporter
 IPR005828  Major facilitator, sugar transporter-like
 IPR005829  Sugar transporter, conserved site
 IPR020846  Major facilitator superfamily domain
 IPR036259  MFS transporter superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process TAS
 biological_processGO:0008643 carbohydrate transport IEA
 biological_processGO:0010021 amylopectin biosynthetic process IEA
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0042593 glucose homeostasis IDA
 biological_processGO:0044381 glucose import in response to insulin stimulus IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0046323 glucose import NAS
 biological_processGO:0050873 brown fat cell differentiation IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0071470 cellular response to osmotic stress IEA
 biological_processGO:1904659 glucose transmembrane transport IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005771 multivesicular body IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0005905 clathrin-coated pit IEA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0012505 endomembrane system ISS
 cellular_componentGO:0012506 vesicle membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030136 clathrin-coated vesicle IDA
 cellular_componentGO:0030140 trans-Golgi network transport vesicle IEA
 cellular_componentGO:0030315 T-tubule IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IEA
 cellular_componentGO:0031982 vesicle IEA
 cellular_componentGO:0032593 insulin-responsive compartment ISS
 cellular_componentGO:0042383 sarcolemma IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0070062 extracellular exosome IEA
 molecular_functionGO:0005215 transporter activity IEA
 molecular_functionGO:0005355 glucose transmembrane transporter activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0022857 transmembrane transporter activity IEA
 molecular_functionGO:0055056 D-glucose transmembrane transporter activity TAS


Pathways (from Reactome)
Pathway description
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Cellular hexose transport
Transcriptional regulation of white adipocyte differentiation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000169696 Q9BZE9 / ASPSCR1 / ASPSCR1, UBX domain containing tether for SLC2A4  / complex
 ENSG00000181856 P14672 / SLC2A4 / solute carrier family 2 member 4  / complex






 

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