ENSG00000059804


Homo sapiens

Features
Gene ID: ENSG00000059804
  
Biological name :SLC2A3
  
Synonyms : P11169 / SLC2A3 / solute carrier family 2 member 3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: p13.31
Gene start: 7919230
Gene end: 7936275
  
Corresponding Affymetrix probe sets: 202497_x_at (Human Genome U133 Plus 2.0 Array)   202498_s_at (Human Genome U133 Plus 2.0 Array)   202499_s_at (Human Genome U133 Plus 2.0 Array)   216236_s_at (Human Genome U133 Plus 2.0 Array)   222088_s_at (Human Genome U133 Plus 2.0 Array)   236571_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000440750
Ensembl peptide - ENSP00000441496
Ensembl peptide - ENSP00000075120
NCBI entrez gene - 6515     See in Manteia.
OMIM - 138170
RefSeq - NM_006931
RefSeq Peptide - NP_008862
swissprot - P11169
swissprot - F5GYR5
swissprot - F5GYX0
Ensembl - ENSG00000059804
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SLC2A14ENSGALG00000014324Gallus gallus
 P32037ENSMUSG00000003153Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8TDB8 / SLC2A14 / solute carrier family 2 member 14ENSG0000017326295
P11166 / SLC2A1 / solute carrier family 2 member 1ENSG0000011739464
P14672 / SLC2A4 / solute carrier family 2 member 4ENSG0000018185657
P11168 / SLC2A2 / solute carrier family 2 member 2ENSG0000016358153
P22732 / SLC2A5 / solute carrier family 2 member 5ENSG0000014258340
Q6PXP3 / SLC2A7 / solute carrier family 2 member 7ENSG0000019724139
Q9NRM0 / SLC2A9 / solute carrier family 2 member 9ENSG0000010966735
Q9BYW1 / SLC2A11 / solute carrier family 2 member 11ENSG0000013346030


Protein motifs (from Interpro)
Interpro ID Name
 IPR002945  Glucose transporter, type 3 (GLUT3)
 IPR003663  Sugar/inositol transporter
 IPR005828  Major facilitator, sugar transporter-like
 IPR005829  Sugar transporter, conserved site
 IPR020846  Major facilitator superfamily domain
 IPR036259  MFS transporter superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process NAS
 biological_processGO:0008643 carbohydrate transport IEA
 biological_processGO:0019852 L-ascorbic acid metabolic process TAS
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0070837 dehydroascorbic acid transport IEA
 biological_processGO:1904659 glucose transmembrane transport TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030667 secretory granule membrane TAS
 cellular_componentGO:0035579 specific granule membrane TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0070821 tertiary granule membrane TAS
 cellular_componentGO:0101003 ficolin-1-rich granule membrane TAS
 molecular_functionGO:0005215 transporter activity IEA
 molecular_functionGO:0005355 glucose transmembrane transporter activity IDA
 molecular_functionGO:0005536 glucose binding IDA
 molecular_functionGO:0022857 transmembrane transporter activity IEA
 molecular_functionGO:0033300 dehydroascorbic acid transmembrane transporter activity EXP
 molecular_functionGO:0055056 D-glucose transmembrane transporter activity EXP


Pathways (from Reactome)
Pathway description
Cellular hexose transport
Vitamin C (ascorbate) metabolism
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000708 Behavioural/Psychiatric Abnormality 
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 HP:0000726 Dementia 
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 HP:0001257 Spasticity "A motor disorder characterized by a velocity-dependent increase in tonic stretch reflexes with increased muscle tone, exaggerated (hyperexcitable) tendon reflexes." [HPO:curators]
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 HP:0001608 Abnormality of the voice "Any abnormality of the voice." [HPO:curators]
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 HP:0002120 Cerebral cortical atrophy 
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 HP:0002353 EEG abnormalities "Abnormality observed by electroencephalogram (EEG), which is used to record of the brain s spontaneous electrical activity from multiple electrodes placed on the scalp." [HPO:curators]
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 HP:0002376 Developmental regression 
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 HP:0100022 Abnormality of movement "An abnormality of movement with a neurological basis characterized by changes in coordination and speed of voluntary movements." [HPO:probinson]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000059804 P11169 / SLC2A3 / solute carrier family 2 member 3  / complex






 

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© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr