ENSMUSG00000028645


Mus musculus

Features
Gene ID: ENSMUSG00000028645
  
Biological name :Slc2a1
  
Synonyms : P17809 / Slc2a1 / solute carrier family 2 (facilitated glucose transporter), member 1
  
Possible biological names infered from orthology : P11166 / solute carrier family 2 member 1
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D2.1
Gene start: 119108711
Gene end: 119137983
  
Corresponding Affymetrix probe sets: 10507594 (MoGene1.0st)   1426599_a_at (Mouse Genome 430 2.0 Array)   1426600_at (Mouse Genome 430 2.0 Array)   1434773_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000134126
Ensembl peptide - ENSMUSP00000146958
Ensembl peptide - ENSMUSP00000134714
Ensembl peptide - ENSMUSP00000030398
Ensembl peptide - ENSMUSP00000118641
NCBI entrez gene - 20525     See in Manteia.
MGI - MGI:95755
RefSeq - XM_006502908
RefSeq - NM_011400
RefSeq Peptide - NP_035530
swissprot - G3V010
swissprot - A0A140LIU2
swissprot - A2A7P3
swissprot - P17809
swissprot - G3UYL0
Ensembl - ENSMUSG00000028645
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc2a1aENSDARG00000001437Danio rerio
 slc2a1bENSDARG00000007412Danio rerio
 SLC2A1ENSGALG00000004889Gallus gallus
 P11166ENSG00000117394Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P14142 / Slc2a4 / solute carrier family 2 (facilitated glucose transporter), member 4 / P14672* / solute carrier family 2 member 4*ENSMUSG0000001856666
P32037 / Slc2a3 / solute carrier family 2 (facilitated glucose transporter), member 3 / P11169* / Q8TDB8* / SLC2A14* / solute carrier family 2 member 3* / solute carrier family 2 member 14*ENSMUSG0000000315365
P14246 / Slc2a2 / solute carrier family 2 (facilitated glucose transporter), member 2 / P11168* / solute carrier family 2 member 2*ENSMUSG0000002769054
Q9WV38 / Slc2a5 / solute carrier family 2 (facilitated glucose transporter), member 5 / P22732* / solute carrier family 2 member 5*ENSMUSG0000002897642
Slc2a7 / solute carrier family 2 (facilitated glucose transporter), member 7 / Q6PXP3* / solute carrier family 2 member 7*ENSMUSG0000006206440
Slc2a9 / solute carrier family 2 (facilitated glucose transporter), member 9 / Q9NRM0* / solute carrier family 2 member 9*ENSMUSG0000000510739


Protein motifs (from Interpro)
Interpro ID Name
 IPR002439  Glucose transporter, type 1 (GLUT1)
 IPR003663  Sugar/inositol transporter
 IPR005828  Major facilitator, sugar transporter-like
 IPR005829  Sugar transporter, conserved site
 IPR020846  Major facilitator superfamily domain
 IPR036259  MFS transporter superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006970 response to osmotic stress IEA
 biological_processGO:0007565 female pregnancy IEA
 biological_processGO:0008643 carbohydrate transport IEA
 biological_processGO:0021987 cerebral cortex development IEA
 biological_processGO:0032868 response to insulin IEA
 biological_processGO:0042149 cellular response to glucose starvation IDA
 biological_processGO:0042908 xenobiotic transport IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0065003 protein-containing complex assembly IEA
 biological_processGO:0070837 dehydroascorbic acid transport IEA
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:0071474 cellular hyperosmotic response IEA
 biological_processGO:1904016 response to Thyroglobulin triiodothyronine IEA
 biological_processGO:1904659 glucose transmembrane transport IEA
 cellular_componentGO:0001939 female pronucleus IDA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0005901 caveola IEA
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0014704 intercalated disc IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IDA
 cellular_componentGO:0016324 apical plasma membrane IDA
 cellular_componentGO:0030018 Z disc IEA
 cellular_componentGO:0030496 midbody IEA
 cellular_componentGO:0030864 cortical actin cytoskeleton IEA
 cellular_componentGO:0031982 vesicle IDA
 cellular_componentGO:0042383 sarcolemma IEA
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0045121 membrane raft IDA
 molecular_functionGO:0005215 transporter activity IEA
 molecular_functionGO:0005355 glucose transmembrane transporter activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019900 kinase binding IEA
 molecular_functionGO:0022857 transmembrane transporter activity IEA
 molecular_functionGO:0033300 dehydroascorbic acid transmembrane transporter activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042910 xenobiotic transmembrane transporter activity IEA
 molecular_functionGO:0043621 protein self-association IEA
 molecular_functionGO:0055056 D-glucose transmembrane transporter activity IEA


Pathways (from Reactome)
Pathway description
Cellular hexose transport
Vitamin C (ascorbate) metabolism
Regulation of insulin secretion
Lactose synthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000951 sporadic seizures "occasional seizures occuring at irregular intervals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nogtm1Amc/Nog+
Genetic Background: involves: 129S1/Sv * CD-1

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Nogtm1Amc/Nog+
Genetic Background: involves: 129S1/Sv * CD-1

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Nogtm1Amc/Nog+
Genetic Background: involves: 129S1/Sv * CD-1

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nogtm1Amc/Nog+
Genetic Background: involves: 129S1/Sv * CD-1

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nogtm1Amc/Nog+
Genetic Background: involves: 129S1/Sv * CD-1

 MP:0002175 low brain weight "lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nogtm1Amc/Nog+
Genetic Background: involves: 129S1/Sv * CD-1

 MP:0003926 impaired cellular glucose import "reduced ability of a cell to take in glucose from the environment" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Nogtm1Amc/Nog+
Genetic Background: involves: 129S1/Sv * CD-1

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nogtm1Amc/Nog+
Genetic Background: involves: 129S1/Sv * CD-1

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Nogtm1Amc/Nog+
Genetic Background: involves: 129S1/Sv * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028645 P17809 / Slc2a1 / solute carrier family 2 (facilitated glucose transporter), member 1 / P11166* / solute carrier family 2 member 1*  / complex






 

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