ENSMUSG00000005299


Mus musculus

Features
Gene ID: ENSMUSG00000005299
  
Biological name :Letm1
  
Synonyms : Letm1 / Mitochondrial proton/calcium exchanger protein / Q9Z2I0
  
Possible biological names infered from orthology : leucine zipper and EF-hand containing transmembrane protein 1 / O95202
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: B2
Gene start: 33739673
Gene end: 33782817
  
Corresponding Affymetrix probe sets: 10529313 (MoGene1.0st)   1420825_at (Mouse Genome 430 2.0 Array)   1420826_at (Mouse Genome 430 2.0 Array)   1435300_at (Mouse Genome 430 2.0 Array)   1460284_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000005431
Ensembl peptide - ENSMUSP00000144491
Ensembl peptide - ENSMUSP00000143805
NCBI entrez gene - 56384     See in Manteia.
MGI - MGI:1932557
RefSeq - NM_019694
RefSeq - XM_006504034
RefSeq Peptide - NP_062668
swissprot - A0A0J9YV52
swissprot - Q9Z2I0
swissprot - A0A0J9YTQ9
Ensembl - ENSMUSG00000005299
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 letm1ENSDARG00000056978Danio rerio
 LETM1ENSGALG00000015706Gallus gallus
 LETM1ENSG00000168924Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Letm2 / Q7TNU7 / LETM1 domain-containing protein LETM2, mitochondrial / Q2VYF4* / leucine zipper and EF-hand containing transmembrane protein 2*ENSMUSG0000003736329


Protein motifs (from Interpro)
Interpro ID Name
 IPR011685  LETM1-like
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site
 IPR033122  Letm1 ribosome-binding domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0006851 mitochondrial calcium ion transmembrane transport IEA
 biological_processGO:0006875 cellular metal ion homeostasis IBA
 biological_processGO:0034214 protein hexamerization IDA
 biological_processGO:0042407 cristae formation IEA
 biological_processGO:0051260 protein homooligomerization IDA
 biological_processGO:0051560 mitochondrial calcium ion homeostasis IEA
 biological_processGO:0099093 calcium export from the mitochondrion IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005743 mitochondrial inner membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0015297 antiporter activity IEA
 molecular_functionGO:0015369 calcium:proton antiporter activity IDA
 molecular_functionGO:0043022 ribosome binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Braftm1Cpri/Braftm1Cpri,Gnastm3Lsw/Gnastm3Lsw,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB/NCr

Allelic Composition: Letm1Gt(CC0204)Wtsi/Letm1+
Genetic Background: 129S.129P2-Letm1Gt(CC0204)Wtsi

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Braftm1Cpri/Braftm1Cpri,Gnastm3Lsw/Gnastm3Lsw,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB/NCr

Allelic Composition: Letm1Gt(CC0204)Wtsi/Letm1+
Genetic Background: 129S.129P2-Letm1Gt(CC0204)Wtsi

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Braftm1Cpri/Braftm1Cpri,Gnastm3Lsw/Gnastm3Lsw,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB/NCr

Allelic Composition: Letm1Gt(CC0204)Wtsi/Letm1+
Genetic Background: 129S.129P2-Letm1Gt(CC0204)Wtsi

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Braftm1Cpri/Braftm1Cpri,Gnastm3Lsw/Gnastm3Lsw,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB/NCr

Allelic Composition: Letm1Gt(CC0204)Wtsi/Letm1+
Genetic Background: 129S.129P2-Letm1Gt(CC0204)Wtsi

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
Show

Allelic Composition: Braftm1Cpri/Braftm1Cpri,Gnastm3Lsw/Gnastm3Lsw,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB/NCr

Allelic Composition: Letm1Gt(CC0204)Wtsi/Letm1+
Genetic Background: 129S.129P2-Letm1Gt(CC0204)Wtsi

 MP:0002834 decreased heart weight "less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Braftm1Cpri/Braftm1Cpri,Gnastm3Lsw/Gnastm3Lsw,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB/NCr

Allelic Composition: Letm1Gt(CC0204)Wtsi/Letm1+
Genetic Background: 129S.129P2-Letm1Gt(CC0204)Wtsi

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
Show

Allelic Composition: Braftm1Cpri/Braftm1Cpri,Gnastm3Lsw/Gnastm3Lsw,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB/NCr

Allelic Composition: Letm1Gt(CC0204)Wtsi/Letm1+
Genetic Background: 129S.129P2-Letm1Gt(CC0204)Wtsi

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Braftm1Cpri/Braftm1Cpri,Gnastm3Lsw/Gnastm3Lsw,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB/NCr

Allelic Composition: Letm1Gt(CC0204)Wtsi/Letm1+
Genetic Background: 129S.129P2-Letm1Gt(CC0204)Wtsi

 MP:0005290 decreased oxygen consumption "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Braftm1Cpri/Braftm1Cpri,Gnastm3Lsw/Gnastm3Lsw,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB/NCr

Allelic Composition: Letm1Gt(CC0204)Wtsi/Letm1+
Genetic Background: 129S.129P2-Letm1Gt(CC0204)Wtsi

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Braftm1Cpri/Braftm1Cpri,Gnastm3Lsw/Gnastm3Lsw,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB/NCr

Allelic Composition: Letm1Gt(CC0204)Wtsi/Letm1+
Genetic Background: 129S.129P2-Letm1Gt(CC0204)Wtsi

 MP:0006036 abnormal mitochondrial physiology 
Show

Allelic Composition: Braftm1Cpri/Braftm1Cpri,Gnastm3Lsw/Gnastm3Lsw,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB/NCr

Allelic Composition: Letm1Gt(CC0204)Wtsi/Letm1+
Genetic Background: 129S.129P2-Letm1Gt(CC0204)Wtsi

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Braftm1Cpri/Braftm1Cpri,Gnastm3Lsw/Gnastm3Lsw,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB/NCr

Allelic Composition: Letm1Gt(CC0204)Wtsi/Letm1Gt(CC0204)Wtsi
Genetic Background: 129S.129P2-Letm1Gt(CC0204)Wtsi

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Braftm1Cpri/Braftm1Cpri,Gnastm3Lsw/Gnastm3Lsw,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB/NCr

Allelic Composition: Letm1Gt(CC0204)Wtsi/Letm1+
Genetic Background: 129S.129P2-Letm1Gt(CC0204)Wtsi

 MP:0013242 abnormal amino acid metabolism "any anomaly in the chemical reactions and pathways involving an amino acid, including metabolic, catabolic and biosynthetic processes" [MPD:Molly]
Show

Allelic Composition: Braftm1Cpri/Braftm1Cpri,Gnastm3Lsw/Gnastm3Lsw,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB/NCr

Allelic Composition: Letm1Gt(CC0204)Wtsi/Letm1+
Genetic Background: 129S.129P2-Letm1Gt(CC0204)Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000005299 Letm1 / Q9Z2I0 / Mitochondrial proton/calcium exchanger protein / O95202* / leucine zipper and EF-hand containing transmembrane protein 1*  / complex






 

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