ENSMUSG00000005615


Mus musculus

Features
Gene ID: ENSMUSG00000005615
  
Biological name :Pcyt1a
  
Synonyms : Choline-phosphate cytidylyltransferase A / P49586 / Pcyt1a
  
Possible biological names infered from orthology : P49585 / phosphate cytidylyltransferase 1, choline, alpha
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: B3
Gene start: 32430921
Gene end: 32475070
  
Corresponding Affymetrix probe sets: 10435057 (MoGene1.0st)   1421957_a_at (Mouse Genome 430 2.0 Array)   1424453_at (Mouse Genome 430 2.0 Array)   1438011_at (Mouse Genome 430 2.0 Array)   1450434_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000078721
Ensembl peptide - ENSMUSP00000110790
Ensembl peptide - ENSMUSP00000110793
Ensembl peptide - ENSMUSP00000130056
NCBI entrez gene - 13026     See in Manteia.
MGI - MGI:88557
RefSeq - NM_001163159
RefSeq - NM_001163160
RefSeq - NM_009981
RefSeq Peptide - NP_001156631
RefSeq Peptide - NP_001156632
RefSeq Peptide - NP_034111
swissprot - P49586
swissprot - D3Z3T5
Ensembl - ENSMUSG00000005615
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pcyt1aaENSDARG00000011233Danio rerio
 pcyt1abENSDARG00000004492Danio rerio
 PCYT1AENSGALG00000007474Gallus gallus
 P49585ENSG00000161217Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pcyt1b / Q811Q9 / Choline-phosphate cytidylyltransferase B / Q9Y5K3* / phosphate cytidylyltransferase 1, choline, beta*ENSMUSG0000003524667


Protein motifs (from Interpro)
Interpro ID Name
 IPR004821  Cytidyltransferase-like domain
 IPR014729  Rossmann-like alpha/beta/alpha sandwich fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006656 phosphatidylcholine biosynthetic process IMP
 biological_processGO:0006657 CDP-choline pathway IEA
 biological_processGO:0008654 phospholipid biosynthetic process IEA
 biological_processGO:0009058 biosynthetic process IEA
 cellular_componentGO:0005635 nuclear envelope IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IDA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0042587 glycogen granule IDA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004105 choline-phosphate cytidylyltransferase activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016779 nucleotidyltransferase activity IEA
 molecular_functionGO:0031210 phosphatidylcholine binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of PC


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001177 atelectasis "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Pim1-E2F1)Rebr/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * FVB * FVB/N

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Gt(ROSA)26Sortm1(Pim1-E2F1)Rebr/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * FVB * FVB/N

 MP:0001728 failure of implantation "inability of the blastocyst to attach to the endometrium of the uterus" [J:38772]
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Allelic Composition: Efnb1tm1.1Sor/Efnb1+,Efnb2tm2Sor/Efnb2tm2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Efnb1tm1.1Sor/Efnb1+,Efnb2tm2Sor/Efnb2tm2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0001819 abnormal immune cell physiology "abnormal function of the cells of the immune system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fbxw4Dac-2J/Fbxw4Dac-2J
Genetic Background: CBy.MRL-Fbxw4Dac-2J/J

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Gt(ROSA)26Sortm1(Pim1-E2F1)Rebr/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * FVB * FVB/N

 MP:0002275 abnormal type II pneumocyte morphology "any structural anomaly of the epithelial cells lining the alveoli that produce surfactant " [Pathology , 2nd edition:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Pim1-E2F1)Rebr/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * FVB * FVB/N

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fbxw4Dac-2J/Fbxw4Dac-2J
Genetic Background: CBy.MRL-Fbxw4Dac-2J/J

 MP:0002663 failure to form blastocele "developmental anomaly resulting in the absence of the cavity in the blastula of the developing embryo" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:19904]
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Allelic Composition: Efnb1tm1.1Sor/Efnb1+,Efnb2tm2Sor/Efnb2tm2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0004007 abnormal lung vasculature "malformation or disorganization of the blood vessels of the lung" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(Pim1-E2F1)Rebr/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * FVB * FVB/N

 MP:0004780 abnormal surfactant secretion "anomaly in the production or release from pneumocytes of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Pim1-E2F1)Rebr/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * FVB * FVB/N

 MP:0004781 abnormal surfactant composition "anomaly in the chemical consituents of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Pim1-E2F1)Rebr/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * FVB * FVB/N

 MP:0005317 increased triglyceride level "higher than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Pim1-E2F1)Rebr/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * FVB * FVB/N

 MP:0009781 abnormal preimplantation embryo development "an anomaly in the developmental progress of an embryo from 2 cell to blastocyst affecting the viability or number of embryos" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Efnb1tm1.1Sor/Efnb1+,Efnb2tm2Sor/Efnb2tm2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0010018 lung vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the lung" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Pim1-E2F1)Rebr/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * FVB * FVB/N

 MP:0010811 decreased type II pneumocyte number "reduced number of the granular and roughly cuboidal cells typically found at the alveolar-septal junction that modulate the fluid surrounding the alveolar epithelium by secreting and recycling surfactants, and also contribute to tissue repair and can differentiate after injury into a type I pneumocyte; type II cells cover a much smaller surface area than type I cells (less than 5 percent), but are much more numerous and contain lamellar bodies on the apical surface where surfactant is stored" [ISBN:0412046911, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", PMID:8540632]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Pim1-E2F1)Rebr/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * FVB * FVB/N

 MP:0010825 abnormal lung saccule morphology "any structural anomaly of the transient dilations of the developing alveolar (or transient) ducts, which transform into a transitory alveolar duct as soon as it develops further branches; the last transitory saccule formed on each pathway is a terminal saccule that develops into an alveolar sac after birth" [GO:0060430, ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Pim1-E2F1)Rebr/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * FVB * FVB/N

 MP:0010890 decreased alveolar lamellar body number "reduced number of the specialized secretory organelles found in the cytoplasm of type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Pim1-E2F1)Rebr/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * FVB * FVB/N

 MP:0010902 abnormal pulmonary alveolar sac morphology "any structural anomaly of the small terminal dilation of the alveolar ducts around which the alveoli form pocket-like clusters" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Pim1-E2F1)Rebr/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * FVB * FVB/N

 MP:0010903 abnormal pulmonary alveolus wall morphology 
Show

Allelic Composition: Gt(ROSA)26Sortm1(Pim1-E2F1)Rebr/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * FVB * FVB/N

 MP:0011018 pulmonary hyaline membrane formation "abnormal presence of an eosinophilic hyaline (glass-like) material composed of fibrin, proteinaceous exudate and cellular debris, and lining or filling the alveoli, alveolar ducts and bronchioles; hyaline membranes block gas exchange and are usually found at autopsy in individuals that have died of respiratory distress syndrome in the neonatal stages" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Pim1-E2F1)Rebr/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * FVB * FVB/N

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Pim1-E2F1)Rebr/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * FVB * FVB/N

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Pim1-E2F1)Rebr/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * FVB * FVB/N

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Efnb1tm1.1Sor/Efnb1+,Efnb2tm2Sor/Efnb2tm2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000005615 P49586 / Pcyt1a / Choline-phosphate cytidylyltransferase A / P49585* / phosphate cytidylyltransferase 1, choline, alpha*  / complex






 

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