ENSMUSG00000035246


Mus musculus

Features
Gene ID: ENSMUSG00000035246
  
Biological name :Pcyt1b
  
Synonyms : Choline-phosphate cytidylyltransferase B / Pcyt1b / Q811Q9
  
Possible biological names infered from orthology : phosphate cytidylyltransferase 1, choline, beta / Q9Y5K3
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: C3
Gene start: 93654863
Gene end: 93749951
  
Corresponding Affymetrix probe sets: 10600765 (MoGene1.0st)   1436124_at (Mouse Genome 430 2.0 Array)   1437648_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000044280
Ensembl peptide - ENSMUSP00000109566
NCBI entrez gene - 236899     See in Manteia.
MGI - MGI:2147987
RefSeq - XM_006527985
RefSeq - NM_177546
RefSeq - NM_211138
RefSeq Peptide - NP_997593
RefSeq Peptide - NP_808214
swissprot - Q811Q9
Ensembl - ENSMUSG00000035246
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pcyt1baENSDARG00000058162Danio rerio
 pcyt1bbENSDARG00000104207Danio rerio
 PCYT1BENSGALG00000016318Gallus gallus
 PCYT1BENSG00000102230Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P49586 / Pcyt1a / Choline-phosphate cytidylyltransferase A / P49585* / phosphate cytidylyltransferase 1, choline, alpha*ENSMUSG0000000561567


Protein motifs (from Interpro)
Interpro ID Name
 IPR004821  Cytidyltransferase-like domain
 IPR014729  Rossmann-like alpha/beta/alpha sandwich fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001541 ovarian follicle development IMP
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006656 phosphatidylcholine biosynthetic process IEA
 biological_processGO:0006657 CDP-choline pathway IEA
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0008654 phospholipid biosynthetic process IEA
 biological_processGO:0009058 biosynthetic process IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004105 choline-phosphate cytidylyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016779 nucleotidyltransferase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of PC


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001126 abnormal ovary morphology "malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Lrp1btm1Her/Lrp1btm1Her,Lrpap1tm1Her/Lrpap1tm1Her
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001128 ovary hyperplasia "increased cell number in the ovary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
Show

Allelic Composition: Lrp1btm1Her/Lrp1btm1Her,Lrpap1tm1Her/Lrpap1tm1Her
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001134 absent corpora lutea "missing yellow endocrine body formed in the ovary after follicle rupture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Lrp1btm1Her/Lrp1btm1Her,Lrpap1tm1Her/Lrpap1tm1Her
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Pcyt1btm1Mkar/Pcyt1b+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001154 seminiferous tubule degeneration "a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844]
Show

Allelic Composition: Pcyt1btm1Mkar/Pcyt1b+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Pcyt1btm1Mkar/Pcyt1b+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001750 increased circulating follicle stimulating hormone level "higher than normal levels in the blood stream of FSH, the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [J:35782, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lrp1btm1Her/Lrp1btm1Her,Lrpap1tm1Her/Lrpap1tm1Her
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001751 increased circulating luteinizing hormone level "higher than the normal levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary" [J:35782, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lrp1btm1Her/Lrp1btm1Her,Lrpap1tm1Her/Lrpap1tm1Her
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Pcyt1btm1Mkar/Pcyt1b+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Lrp1btm1Her/Lrp1btm1Her,Lrpap1tm1Her/Lrpap1tm1Her
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Pcyt1btm1Mkar/Pcyt1b+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Lrp1btm1Her/Lrp1btm1Her,Lrpap1tm1Her/Lrpap1tm1Her
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002777 absent ovarian follicles "lack of the sac-like structures in the ovaries that surround the ova" [J:42612, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lrp1btm1Her/Lrp1btm1Her,Lrpap1tm1Her/Lrpap1tm1Her
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Pcyt1btm1Mkar/Pcyt1b+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0003205 testicular atrophy "wasting of the male reproductive glands resulting in reduced size" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Pcyt1btm1Mkar/Pcyt1b+
Genetic Background: involves: 129S1/Sv * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000035246 Pcyt1b / Q811Q9 / Choline-phosphate cytidylyltransferase B / Q9Y5K3* / phosphate cytidylyltransferase 1, choline, beta*  / complex






 

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