ENSMUSG00000005686


Mus musculus

Features
Gene ID: ENSMUSG00000005686
  
Biological name :Ampd3
  
Synonyms : Ampd3 / AMP deaminase 3 / O08739
  
Possible biological names infered from orthology : adenosine monophosphate deaminase 3 / Q01432
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: E3
Gene start: 110768206
Gene end: 110812405
  
Corresponding Affymetrix probe sets: 10556302 (MoGene1.0st)   1422573_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000122657
Ensembl peptide - ENSMUSP00000121238
Ensembl peptide - ENSMUSP00000130495
Ensembl peptide - ENSMUSP00000149655
Ensembl peptide - ENSMUSP00000005829
Ensembl peptide - ENSMUSP00000120983
NCBI entrez gene - 11717     See in Manteia.
MGI - MGI:1096344
RefSeq - XM_017321938
RefSeq - NM_009667
RefSeq - XM_006507215
RefSeq - XM_006507217
RefSeq - XM_006507219
RefSeq - XM_006507221
RefSeq - XM_006507222
RefSeq - XM_017321937
RefSeq - NM_001276301
RefSeq Peptide - NP_001263230
RefSeq Peptide - NP_033797
swissprot - D3YU73
swissprot - D3Z4N3
swissprot - A0A1L1SRX2
swissprot - O08739
swissprot - F6XQD0
Ensembl - ENSMUSG00000005686
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ampd3aENSDARG00000005800Danio rerio
 ampd3bENSDARG00000032469Danio rerio
 AMPD3ENSGALG00000005662Gallus gallus
 AMPD3ENSG00000133805Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ampd1 / Q3V1D3 / AMP deaminase 1 / P23109* / adenosine monophosphate deaminase 1*ENSMUSG0000007038558
Ampd2 / Q9DBT5 / Mus musculus adenosine monophosphate deaminase 2 (Ampd2), transcript variant 4, mRNA. / Q01433* / adenosine monophosphate deaminase 2*ENSMUSG0000002788950


Protein motifs (from Interpro)
Interpro ID Name
 IPR001365  Adenosine/AMP deaminase domain
 IPR006329  AMP deaminase
 IPR006650  Adenosine/AMP deaminase active site
 IPR029771  AMP deaminase 3
 IPR032466  Metal-dependent hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006188 IMP biosynthetic process IMP
 biological_processGO:0009117 nucleotide metabolic process IEA
 biological_processGO:0009168 purine ribonucleoside monophosphate biosynthetic process IEA
 biological_processGO:0032264 IMP salvage IEA
 biological_processGO:0034101 erythrocyte homeostasis IMP
 biological_processGO:0046031 ADP metabolic process IMP
 biological_processGO:0046033 AMP metabolic process IMP
 biological_processGO:0046034 ATP metabolic process IGI
 biological_processGO:0046039 GTP metabolic process IMP
 biological_processGO:0097009 energy homeostasis IMP
 cellular_componentGO:0005575 cellular_component ND
 molecular_functionGO:0003876 AMP deaminase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019239 deaminase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation
Purine salvage


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Akap9tm1a(KOMP)Wtsi/Akap9tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Akap9tm1a(KOMP)Wtsi/Wtsi

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ampd3tm1Tm/Ampd3tm1Tm,Pklrslc/Pklrslc
Genetic Background: involves: CBA/NSlc

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Ampd2tm1Tm/Ampd2tm1Tm,Ampd3tm2a(KOMP)Wtsi/Ampd3tm2a(KOMP)Wtsi
Genetic Background: involves: 129S2/SvPas * C57BL/6N

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Ampd2tm1Tm/Ampd2tm1Tm,Ampd3tm2a(KOMP)Wtsi/Ampd3tm2a(KOMP)Wtsi
Genetic Background: involves: 129S2/SvPas * C57BL/6N

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Ampd3tm1Tm/Ampd3tm1Tm,Pklrslc/Pklrslc
Genetic Background: involves: CBA/NSlc

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ass1tm1.2Ekoe/Ass1tm1.2Ekoe
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ampd2tm1Tm/Ampd2tm1Tm,Ampd3tm2a(KOMP)Wtsi/Ampd3tm2a(KOMP)Wtsi
Genetic Background: involves: 129S2/SvPas * C57BL/6N

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ampd3tm1Tm/Ampd3tm1Tm,Pklrslc/Pklrslc
Genetic Background: involves: CBA/NSlc

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ass1tm1.2Ekoe/Ass1tm1.2Ekoe
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Ampd3tm1Tm/Ampd3tm1Tm,Pklrslc/Pklrslc
Genetic Background: involves: CBA/NSlc

 MP:0003656 abnormal erythrocyte physiology "functional anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ass1tm1.2Ekoe/Ass1tm1.2Ekoe
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

Allelic Composition: Ampd3tm1Tm/Ampd3tm1Tm,Pklrslc/Pklrslc
Genetic Background: involves: CBA/NSlc

 MP:0003657 abnormal erythrocyte lysis "increase or decrease in the ability of RBCs to withstand changes in osmolarity" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ass1tm1.2Ekoe/Ass1tm1.2Ekoe
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

Allelic Composition: Ampd3tm1Tm/Ampd3tm1Tm,Pklrslc/Pklrslc
Genetic Background: involves: CBA/NSlc

 MP:0003806 abnormal nucleotide metabolism "impaired regulation of nucleotide levels in either production or breakdown of these structural components of nucleic acids" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ampd2tm1Tm/Ampd2tm1Tm,Ampd3tm2a(KOMP)Wtsi/Ampd3tm2a(KOMP)Wtsi
Genetic Background: involves: 129S2/SvPas * C57BL/6N

Allelic Composition: Ampd3tm2a(KOMP)Wtsi/Ampd3tm2a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N * C57BL/6NHsd

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Akap9tm1a(KOMP)Wtsi/Akap9tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Akap9tm1a(KOMP)Wtsi/Wtsi

 MP:0005288 abnormal oxygen consumption "deviation from the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ampd2tm1Tm/Ampd2tm1Tm,Ampd3tm2a(KOMP)Wtsi/Ampd3tm2a(KOMP)Wtsi
Genetic Background: involves: 129S2/SvPas * C57BL/6N

 MP:0005319 abnormal enzyme/ coenzyme level "altered concentration of any of these proteins, or their cofactors, that act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ampd2tm1Tm/Ampd2tm1Tm,Ampd3tm2a(KOMP)Wtsi/Ampd3tm2a(KOMP)Wtsi
Genetic Background: involves: 129S2/SvPas * C57BL/6N

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Ampd2tm1Tm/Ampd2tm1Tm,Ampd3tm2a(KOMP)Wtsi/Ampd3tm2a(KOMP)Wtsi
Genetic Background: involves: 129S2/SvPas * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000005686 Ampd3 / O08739 / AMP deaminase 3 / Q01432* / adenosine monophosphate deaminase 3*  / complex






 

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