ENSMUSG00000070385


Mus musculus

Features
Gene ID: ENSMUSG00000070385
  
Biological name :Ampd1
  
Synonyms : Ampd1 / AMP deaminase 1 / Q3V1D3
  
Possible biological names infered from orthology : adenosine monophosphate deaminase 1 / P23109
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F2.2
Gene start: 103074014
Gene end: 103099720
  
Corresponding Affymetrix probe sets: 10494873 (MoGene1.0st)   1434722_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000088217
Ensembl peptide - ENSMUSP00000134772
Ensembl peptide - ENSMUSP00000135737
Ensembl peptide - ENSMUSP00000143129
NCBI entrez gene - 229665     See in Manteia.
MGI - MGI:88015
RefSeq - XM_006501400
RefSeq - NM_001033303
RefSeq Peptide - NP_001028475
swissprot - H3BIY4
swissprot - A0A0G2JFD4
swissprot - Q3V1D3
swissprot - H3BLC7
Ensembl - ENSMUSG00000070385
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ampd1ENSDARG00000033832Danio rerio
 AMPD1ENSGALG00000002082Gallus gallus
 AMPD1ENSG00000116748Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ampd3 / O08739 / AMP deaminase 3 / Q01432* / adenosine monophosphate deaminase 3*ENSMUSG0000000568660
Ampd2 / Q9DBT5 / Mus musculus adenosine monophosphate deaminase 2 (Ampd2), transcript variant 4, mRNA. / Q01433* / adenosine monophosphate deaminase 2*ENSMUSG0000002788949


Protein motifs (from Interpro)
Interpro ID Name
 IPR001365  Adenosine/AMP deaminase domain
 IPR006329  AMP deaminase
 IPR006650  Adenosine/AMP deaminase active site
 IPR029770  AMP deaminase 1
 IPR032466  Metal-dependent hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0009117 nucleotide metabolic process IEA
 biological_processGO:0009168 purine ribonucleoside monophosphate biosynthetic process IEA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0032264 IMP salvage IEA
 cellular_componentGO:0005575 cellular_component ND
 molecular_functionGO:0003876 AMP deaminase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019239 deaminase activity IEA
 molecular_functionGO:0032036 myosin heavy chain binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Purine salvage


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adipor1tm1b(EUCOMM)Hmgu/Adipor1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Adipor1tm1b(EUCOMM)Hmgu/H

 MP:0002599 increased mean platelet volume "increased content of platelet cells over the norm" [cml:Cathleen M. Lutz, Mouse Genome Informatics Curator]
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Allelic Composition: Adipor1tm1b(EUCOMM)Hmgu/Adipor1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Adipor1tm1b(EUCOMM)Hmgu/H

 MP:0005012 decreased eosinophil count "fewer than normal eosinophil numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adipor1tm1b(EUCOMM)Hmgu/Adipor1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Adipor1tm1b(EUCOMM)Hmgu/H

 MP:0005385 cardiovascular system phenotype 
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Allelic Composition: Adipor1tm1b(EUCOMM)Hmgu/Adipor1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Adipor1tm1b(EUCOMM)Hmgu/H

 MP:0008935 decreased mean platelet volume "reduced average content of platelet cells over normal" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Adipor1tm1b(EUCOMM)Hmgu/Adipor1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Adipor1tm1b(EUCOMM)Hmgu/H

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Adipor1tm1b(EUCOMM)Hmgu/Adipor1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Adipor1tm1b(EUCOMM)Hmgu/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000070385 Ampd1 / Q3V1D3 / AMP deaminase 1 / P23109* / adenosine monophosphate deaminase 1*  / complex






 

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