ENSMUSG00000027889


Mus musculus

Features
Gene ID: ENSMUSG00000027889
  
Biological name :Ampd2
  
Synonyms : Ampd2 / Mus musculus adenosine monophosphate deaminase 2 (Ampd2), transcript variant 4, mRNA. / Q9DBT5
  
Possible biological names infered from orthology : adenosine monophosphate deaminase 2 / Q01433
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: F2.3
Gene start: 108074062
Gene end: 108086651
  
Corresponding Affymetrix probe sets: 10501244 (MoGene1.0st)   1426757_at (Mouse Genome 430 2.0 Array)   1438941_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000077946
Ensembl peptide - ENSMUSP00000099697
Ensembl peptide - ENSMUSP00000099698
NCBI entrez gene - 109674     See in Manteia.
MGI - MGI:88016
RefSeq - XM_017319424
RefSeq - NM_001289719
RefSeq - NM_001289720
RefSeq - NM_001346665
RefSeq - NM_028779
RefSeq - XM_006500868
RefSeq - XM_006500870
RefSeq - XM_006500871
RefSeq - XM_011239985
RefSeq Peptide - NP_001276648
RefSeq Peptide - NP_001276649
RefSeq Peptide - NP_001333594
RefSeq Peptide - NP_083055
swissprot - Q9DBT5
swissprot - A2AE27
Ensembl - ENSMUSG00000027889
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ampd2aENSDARG00000104491Danio rerio
 ampd2bENSDARG00000029952Danio rerio
 AMPD2ENSGALG00000034009Gallus gallus
 AMPD2ENSG00000116337Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ampd3 / O08739 / AMP deaminase 3 / Q01432* / adenosine monophosphate deaminase 3*ENSMUSG0000000568647
Ampd1 / Q3V1D3 / AMP deaminase 1 / P23109* / adenosine monophosphate deaminase 1*ENSMUSG0000007038544


Protein motifs (from Interpro)
Interpro ID Name
 IPR001365  Adenosine/AMP deaminase domain
 IPR006329  AMP deaminase
 IPR006650  Adenosine/AMP deaminase active site
 IPR029749  AMP deaminase 2
 IPR032466  Metal-dependent hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006188 IMP biosynthetic process IEA
 biological_processGO:0009117 nucleotide metabolic process IMP
 biological_processGO:0009168 purine ribonucleoside monophosphate biosynthetic process IEA
 biological_processGO:0032264 IMP salvage IEA
 biological_processGO:0042632 cholesterol homeostasis IMP
 biological_processGO:0046033 AMP metabolic process IMP
 biological_processGO:0046034 ATP metabolic process IMP
 biological_processGO:0046039 GTP metabolic process IMP
 biological_processGO:0052652 cyclic purine nucleotide metabolic process IEA
 biological_processGO:0072015 glomerular visceral epithelial cell development IMP
 biological_processGO:0097009 energy homeostasis IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0003876 AMP deaminase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019239 deaminase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Purine salvage


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000182 increased circulating LDL cholesterol level "greater than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cebpam4443Dajl/Cebpam4443Dajl
Genetic Background: involves: C3H/HeSnJ * C57BL/6J * SWR

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Cebpam4443Dajl/Cebpam4443Dajl
Genetic Background: involves: C3H/HeSnJ * C57BL/6J * SWR

Allelic Composition: Ampd2tm1Tm/Ampd2tm1Tm,Ampd3tm2a(KOMP)Wtsi/Ampd3tm2a(KOMP)Wtsi
Genetic Background: involves: 129S2/SvPas * C57BL/6N

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Ampd2tm1Tm/Ampd2tm1Tm,Ampd3tm2a(KOMP)Wtsi/Ampd3tm2a(KOMP)Wtsi
Genetic Background: involves: 129S2/SvPas * C57BL/6N

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
Show

Allelic Composition: Cebpam4443Dajl/Cebpam4443Dajl
Genetic Background: involves: C3H/HeSnJ * C57BL/6J * SWR

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ampd2tm1Tm/Ampd2tm1Tm,Ampd3tm2a(KOMP)Wtsi/Ampd3tm2a(KOMP)Wtsi
Genetic Background: involves: 129S2/SvPas * C57BL/6N

 MP:0002703 abnormal renal tubules "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ttm1(cre/ERT2)Hssk/T+
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj * ICR

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Ttm1(cre/ERT2)Hssk/T+
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj * ICR

 MP:0003806 abnormal nucleotide metabolism "impaired regulation of nucleotide levels in either production or breakdown of these structural components of nucleic acids" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ampd2tm1Tm/Ampd2tm1Tm,Ampd3tm2a(KOMP)Wtsi/Ampd3tm2a(KOMP)Wtsi
Genetic Background: involves: 129S2/SvPas * C57BL/6N

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cebpam4443Dajl/Cebpam4443Dajl
Genetic Background: involves: C3H/HeSnJ * C57BL/6J * SWR

 MP:0008140 podocyte foot process effacement "thinning of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ttm1(cre/ERT2)Hssk/T+
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj * ICR

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Ampd2tm1Tm/Ampd2tm1Tm,Ampd3tm2a(KOMP)Wtsi/Ampd3tm2a(KOMP)Wtsi
Genetic Background: involves: 129S2/SvPas * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027889 Ampd2 / Q9DBT5 / Mus musculus adenosine monophosphate deaminase 2 (Ampd2), transcript variant 4, mRNA. / Q01433* / adenosine monophosphate deaminase 2*  / complex






 

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