ENSMUSG00000007038


Mus musculus

Features
Gene ID: ENSMUSG00000007038
  
Biological name :Neu1
  
Synonyms : Neu1 / neuraminidase 1 / O35657
  
Possible biological names infered from orthology : Q99519
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: B1
Gene start: 34931253
Gene end: 34935953
  
Corresponding Affymetrix probe sets: 10444578 (MoGene1.0st)   1416831_at (Mouse Genome 430 2.0 Array)   1447942_x_at (Mouse Genome 430 2.0 Array)   1448481_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000007253
NCBI entrez gene - 18010     See in Manteia.
MGI - MGI:97305
RefSeq - NM_010893
RefSeq Peptide - NP_035023
swissprot - O35657
swissprot - Q3UL64
Ensembl - ENSMUSG00000007038
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 neu1ENSDARG00000008832Danio rerio
 NEU1ENSG00000204386Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR011040  Sialidase
 IPR026856  Sialidase family
 IPR036278  Sialidase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006689 ganglioside catabolic process IBA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009313 oligosaccharide catabolic process IEA
 biological_processGO:0016042 lipid catabolic process IEA
 cellular_componentGO:0005764 lysosome ISO
 cellular_componentGO:0005765 lysosomal membrane IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IBA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0043202 lysosomal lumen IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004308 exo-alpha-sialidase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016798 hydrolase activity, acting on glycosyl bonds IEA
 molecular_functionGO:0016997 alpha-sialidase activity IEA
 molecular_functionGO:0052794 exo-alpha-(2->3)-sialidase activity IEA
 molecular_functionGO:0052795 exo-alpha-(2->6)-sialidase activity IEA
 molecular_functionGO:0052796 exo-alpha-(2->8)-sialidase activity IEA


Pathways (from Reactome)
Pathway description
Glycosphingolipid metabolism
Sialic acid metabolism
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000136 abnormal microglial cell morphology "anomalous structure, number, or composition of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, J:71688]
Show

Allelic Composition: Neu1tm1Adz/Neu1tm1Adz
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * NMRI)

 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Neu1tm1Adz/Neu1tm1Adz
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * NMRI)

 MP:0000162 lordosis "anteriorly convex curvature of the spine, "saddle back" " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62022]
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Allelic Composition: Neu1tm1Adz/Neu1tm1Adz
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * NMRI)

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Neu1tm1Adz/Neu1tm1Adz
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * NMRI)

 MP:0000243 myoclonus "involuntary shock-like contractions, variable in rhythm and amplitude, followed by relaxation, of a muscle or a group of muscles; generally due to a central nervous system lesion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Neu1tm1Adz/Neu1tm1Adz
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * NMRI)

 MP:0000519 hydronephrosis "dilation of the pelvis and calices of one or both kidneys" [J:56641]
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Allelic Composition: Neu1tm1Adz/Neu1tm1Adz
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * NMRI)

 MP:0000539 distended urinary bladder "stretched musculomembranous bag for holding urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Neu1tm1Adz/Neu1tm1Adz
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * NMRI)

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Neu1tm1Adz/Neu1tm1Adz
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * NMRI)

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Neu1tm1Adz/Neu1tm1Adz
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * NMRI)

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Neu1tm1Adz/Neu1tm1Adz
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * NMRI)

 MP:0000820 abnormal choroid plexus morphology "malformed or absent fringe of the tela choroidea of the cerebral ventricles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Neu1tm1Adz/Neu1tm1Adz
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * NMRI)

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
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Allelic Composition: Neu1tm1Adz/Neu1tm1Adz
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * NMRI)

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Cdkn1btm1Mlf/Cdkn1b+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6NHsd

Allelic Composition: Neu1tm1Adz/Neu1tm1Adz
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * NMRI)

Allelic Composition: Neu1a/Neu1a
Genetic Background: B6.SM-Neu1a

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Neu1tm1Adz/Neu1tm1Adz
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * NMRI)

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Neu1tm1Adz/Neu1tm1Adz
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * NMRI)

 MP:0001786 skin edema "accumulation of an excessive amount of fluid in the skin" [J:65039]
Show

Allelic Composition: Neu1tm1Adz/Neu1tm1Adz
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * NMRI)

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Neu1tm1Adz/Neu1tm1Adz
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * NMRI)

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sox8tm1Weg/Sox8+,Sox9tm2Crm/Sox9tm2Crm,Tg(Nr5a1-cre)5Asc/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Neu1tm1Adz/Neu1tm1Adz
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * NMRI)

 MP:0003201 extremity edema "an accumulation of serous fluid in the limbs, paws and tail" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Neu1tm1Adz/Neu1tm1Adz
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * NMRI)

 MP:0003622 incomplete emptying of bladder "upon urination, some urine is retained in the bladder instead of being excreted" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Neu1tm1Adz/Neu1tm1Adz
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * NMRI)

 MP:0004756 abnormal proximal convoluted tubule morphology "any structural anomaly of the convoluted portion of the duct system of the nephron that extends from the renal glomeurlar capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle; fluid entering the proximal convoluted tubule is reabsorbed into the peritubular capillaries, including approximately two-thirds of the filtered salt and water and all filtered organic solutes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1btm1Mlf/Cdkn1b+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6NHsd

 MP:0005058 abnormal lysosome morphology "anomalous structure of any of the cytoplasmic, membrane bound vesicles that contain a variety of hydrolases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Neu1tm1Adz/Neu1tm1Adz
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * NMRI)

 MP:0005060 accumulation of giant lysosomes in kidney/renal tubule cells "buildup of contents in lysosomes in cells of the kidney tubules " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:5590]
Show

Allelic Composition: Neu1tm1Adz/Neu1tm1Adz
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * NMRI)

 MP:0005567 decreased circulating total protein level "less than the average total concentration of these macromolecules in the blood " [RGD:Rat Genome Database submission]
Show

Allelic Composition: Neu1tm1Adz/Neu1tm1Adz
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * NMRI)

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cdkn1btm1Mlf/Cdkn1b+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6NHsd

Allelic Composition: Neu1a/Neu1a
Genetic Background: B6.SM-Neu1a

 MP:0006167 eyelid edema "an abnormal accumulation of fluid in the eyelid" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Neu1tm1Adz/Neu1tm1Adz
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * NMRI)

 MP:0008114 abnormal Kupffer cell morphology "any structural anomaly of the phagocytic macrophages residing on the luminal surface of the hepatic sinusoids" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdkn1btm1Mlf/Cdkn1b+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6NHsd

Allelic Composition: Neu1tm1Adz/Neu1tm1Adz
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * NMRI)

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Neu1tm1Adz/Neu1tm1Adz
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * NMRI)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000045594 Glb1 / P23780 / galactosidase, beta 1 / P16278*  / complex
 ENSMUSG00000017760 Ctsa / P16675 / cathepsin A / P10619*  / complex






 

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