ENSMUSG00000017760


Mus musculus

Features
Gene ID: ENSMUSG00000017760
  
Biological name :Ctsa
  
Synonyms : cathepsin A / Ctsa / P16675
  
Possible biological names infered from orthology : P10619
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: H3
Gene start: 164832873
Gene end: 164841032
  
Corresponding Affymetrix probe sets: 10478594 (MoGene1.0st)   1445659_at (Mouse Genome 430 2.0 Array)   1448128_at (Mouse Genome 430 2.0 Array)   1458466_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099382
Ensembl peptide - ENSMUSP00000123413
Ensembl peptide - ENSMUSP00000119814
Ensembl peptide - ENSMUSP00000116210
Ensembl peptide - ENSMUSP00000115514
Ensembl peptide - ENSMUSP00000017904
Ensembl peptide - ENSMUSP00000099381
NCBI entrez gene - 19025     See in Manteia.
MGI - MGI:97748
RefSeq - NM_008906
RefSeq - NM_001038492
RefSeq Peptide - NP_001033581
RefSeq Peptide - NP_032932
swissprot - P16675
swissprot - A2A5J9
swissprot - Q544R6
swissprot - A2A5J8
swissprot - A2A5J7
swissprot - A2A5J6
swissprot - G3X8T3
Ensembl - ENSMUSG00000017760
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ctsaENSDARG00000098114Danio rerio
 CTSAENSGALG00000006876Gallus gallus
 CTSAENSG00000064601Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001563  Peptidase S10, serine carboxypeptidase
 IPR018202  Serine carboxypeptidase, serine active site
 IPR029058  Alpha/Beta hydrolase fold
 IPR033124  Serine carboxypeptidases, histidine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0031647 regulation of protein stability ISS
 biological_processGO:0051603 proteolysis involved in cellular protein catabolic process IBA
 biological_processGO:1904715 negative regulation of chaperone-mediated autophagy ISS
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005765 lysosomal membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004180 carboxypeptidase activity IEA
 molecular_functionGO:0004185 serine-type carboxypeptidase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Glycosphingolipid metabolism
MHC class II antigen presentation
Sialic acid metabolism
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
Show

Allelic Composition: Stat3tm1Vpo/Stat3tm1Vpo,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cAn * C57BL/6 * CBA

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Stat3tm1Vpo/Stat3tm1Vpo,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cAn * C57BL/6 * CBA

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Stat3tm1Vpo/Stat3tm1Vpo,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cAn * C57BL/6 * CBA

 MP:0001183 overexpanded alveoli "expanded volume of the saclike terminal dilation of the respiratory bronchioles" [J:66345]
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Allelic Composition: Cdsntm1.1Ics/Cdsntm1.1Ics,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Stat3tm1Vpo/Stat3tm1Vpo,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cAn * C57BL/6 * CBA

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Stat3tm1Vpo/Stat3tm1Vpo,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cAn * C57BL/6 * CBA

 MP:0001511 disheveled coat "coat that looks generally unkempt" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Stat3tm1Vpo/Stat3tm1Vpo,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cAn * C57BL/6 * CBA

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cdsntm1.1Ics/Cdsntm1.1Ics,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Stat3tm1Vpo/Stat3tm1Vpo,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cAn * C57BL/6 * CBA

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Stat3tm1Vpo/Stat3tm1Vpo,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cAn * C57BL/6 * CBA

 MP:0003209 abnormal pulmonary elastic fiber morphology "malformation of a slender connective tissue fiber in pulmonary tissue characterized by great elasticity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Cdsntm1.1Ics/Cdsntm1.1Ics,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdsntm1.1Ics/Cdsntm1.1Ics,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0004875 increased mean arterial blood pressure "increase in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdsntm1.1Ics/Cdsntm1.1Ics,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0005058 abnormal lysosome morphology "anomalous structure of any of the cytoplasmic, membrane bound vesicles that contain a variety of hydrolases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Stat3tm1Vpo/Stat3tm1Vpo,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cAn * C57BL/6 * CBA

 MP:0006083 abnormal vascular elastic tissue "malformation in the tissue that is found in the tunica media of the vessels wall and allows vessels to stretch" [smb:Susan M Bello, Mouse Genome Informatics Curator, ncbi:NCBI request]
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Allelic Composition: Cdsntm1.1Ics/Cdsntm1.1Ics,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0006143 increased diastolic blood pressure "abnormal increase in the pressure in the arteries between heart beats when the heart is relaxed" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdsntm1.1Ics/Cdsntm1.1Ics,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0006144 increased systolic blood pressure "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdsntm1.1Ics/Cdsntm1.1Ics,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0008418 abnormal cutaneous elastic fiber morphology "any structural anomaly of the slender connective tissue fiber in the extracellular matrix of skin tissue that is composed of microfibrils and amorphous elastin and is characterized by great elasticity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdsntm1.1Ics/Cdsntm1.1Ics,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0011941 increased fluid intake "increase in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Cdsntm1.1Ics/Cdsntm1.1Ics,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0012175 flat face "the appearance of a flattened surface outline or contour of a normally rounded face of an organism" [MGI:anna]
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Allelic Composition: Stat3tm1Vpo/Stat3tm1Vpo,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cAn * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000017760 Ctsa / P16675 / cathepsin A / P10619*  / complex
 ENSMUSG00000045594 Glb1 / P23780 / galactosidase, beta 1 / P16278*  / complex
 ENSMUSG00000007038 Neu1 / O35657 / neuraminidase 1 / Q99519*  / complex






 

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