ENSMUSG00000045594


Mus musculus

Features
Gene ID: ENSMUSG00000045594
  
Biological name :Glb1
  
Synonyms : galactosidase, beta 1 / Glb1 / P23780
  
Possible biological names infered from orthology : P16278
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: F3
Gene start: 114401076
Gene end: 114474898
  
Corresponding Affymetrix probe sets: 10589889 (MoGene1.0st)   1416205_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000149937
Ensembl peptide - ENSMUSP00000055803
NCBI entrez gene - 12091     See in Manteia.
MGI - MGI:88151
RefSeq - NM_009752
RefSeq Peptide - NP_033882
swissprot - A0A1L1SSJ7
swissprot - P23780
swissprot - Q3TAW7
Ensembl - ENSMUSG00000045594
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 glb1ENSDARG00000036415Danio rerio
 GLB1ENSGALG00000040028Gallus gallus
 GLB1ENSG00000170266Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Glb1l / Q8VC60 / Beta-galactosidase-1-like protein / Q6UWU2* / galactosidase beta 1 like*ENSMUSG0000002620050
Glb1l2 / galactosidase beta 1 like 2 / Q8IW92*ENSMUSG0000003639536
Glb1l3 / galactosidase beta 1 like 3 / Q8NCI6*ENSMUSG0000003196635
Gm1110ENSMUSG0000007964433


Protein motifs (from Interpro)
Interpro ID Name
 IPR001944  Glycoside hydrolase, family 35
 IPR008979  Galactose-binding-like domain superfamily
 IPR017853  Glycoside hydrolase superfamily
 IPR019801  Glycoside hydrolase, family 35, conserved site
 IPR025300  Beta-galactosidase jelly roll domain
 IPR026283  Beta-galactosidase 1-like
 IPR031330  Glycoside hydrolase 35, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0019388 galactose catabolic process IEA
 biological_processGO:0044262 cellular carbohydrate metabolic process IEA
 biological_processGO:0051413 response to cortisone IEA
 biological_processGO:1904016 response to Thyroglobulin triiodothyronine IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005773 vacuole IBA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds IEA
 molecular_functionGO:0004565 beta-galactosidase activity ISO
 molecular_functionGO:0016787 hydrolase activity IDA
 molecular_functionGO:0016798 hydrolase activity, acting on glycosyl bonds IEA
 molecular_functionGO:0016936 galactoside binding IEA


Pathways (from Reactome)
Pathway description
Glycosphingolipid metabolism
Keratan sulfate degradation
HS-GAG degradation
Sialic acid metabolism
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Nod2tm1Flv/Nod2tm1Flv
Genetic Background: involves: 129S1/Sv

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Galctwi/Galctwi,Glb1tm1Adz/Glb1tm1Adz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CE/J

 MP:0000601 small liver "reduced size of the liver" [J:23170]
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Allelic Composition: Pmp22Tr/Pmp22+
Genetic Background: Not Specified

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pmp22Tr/Pmp22+
Genetic Background: Not Specified

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Galctwi/Galctwi,Glb1tm1Adz/Glb1tm1Adz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CE/J

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Glb1tm1Jmat/Glb1tm1Jmat
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Dlg4tm1Grnt/Dlg4tm1Grnt,Syngap1tm1Grnt/Syngap1+
Genetic Background: involves: 129P2/OlaHsd * MF1

Allelic Composition: Glb1tm1Jmat/Glb1tm1Jmat
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0000753 paralysis "loss of power of voluntary movement in a muscle through injury or disease of its nerve supply" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Glb1tm1Jmat/Glb1tm1Jmat
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Dlg4tm1Grnt/Dlg4tm1Grnt,Syngap1tm1Grnt/Syngap1+
Genetic Background: involves: 129P2/OlaHsd * MF1

 MP:0000876 Purkinje cell degeneration "a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [J:46854]
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Allelic Composition: Glb1tm1Jmat/Glb1tm1Jmat
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Galctwi/Galctwi,Glb1tm1Adz/Glb1tm1Adz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CE/J

Allelic Composition: Galctwi/Galctwi,Glb1tm1Adz/Glb1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CE/J

 MP:0001385 pup cannibalization "the killing and eating of newborn mice by the mother; can be a normal response if the mother does not recognize the pups as her own" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Glb1tm1Jmat/Glb1tm1Jmat
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Dlg4tm1Grnt/Dlg4tm1Grnt,Syngap1tm1Grnt/Syngap1+
Genetic Background: involves: 129P2/OlaHsd * MF1

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Glb1tm1Jmat/Glb1tm1Jmat
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Dlg4tm1Grnt/Dlg4tm1Grnt,Syngap1tm1Grnt/Syngap1+
Genetic Background: involves: 129P2/OlaHsd * MF1

Allelic Composition: Glb1tm1Jmat/Glb1tm1Jmat
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0001431 abnormal eating behavior "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]
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Allelic Composition: Pmp22Tr/Pmp22+
Genetic Background: Not Specified

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Pmp22Tr/Pmp22+
Genetic Background: Not Specified

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Galctwi/Galctwi,Glb1tm1Adz/Glb1tm1Adz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CE/J

Allelic Composition: Galctwi/Galctwi,Glb1tm1Adz/Glb1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CE/J

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Glb1tm1Jmat/Glb1tm1Jmat
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Galctwi/Galctwi,Glb1tm1Adz/Glb1tm1Adz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CE/J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pmp22Tr/Pmp22+
Genetic Background: Not Specified

Allelic Composition: Galctwi/Galctwi,Glb1tm1Adz/Glb1tm1Adz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CE/J

Allelic Composition: Galctwi/Galctwi,Glb1tm1Adz/Glb1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CE/J

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Dlg4tm1Grnt/Dlg4tm1Grnt,Syngap1tm1Grnt/Syngap1+
Genetic Background: involves: 129P2/OlaHsd * MF1

Allelic Composition: Glb1tm1Jmat/Glb1tm1Jmat
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0002183 gliosis "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Glb1tm1Jmat/Glb1tm1Jmat
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Galctwi/Galctwi,Glb1tm1Adz/Glb1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CE/J

 MP:0002401 abnormal lymphopoiesis "atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Glb1tm1Jmat/Glb1tm1Jmat
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Galctwi/Galctwi,Glb1tm1Adz/Glb1tm1Adz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CE/J

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Glb1tm1Jmat/Glb1tm1Jmat
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0002828 abnormal glomerular capsule "anomalous structure or development of the expanded beginning of a nephron that contains the glomerulus" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Galctwi/Galctwi,Glb1tm1Adz/Glb1tm1Adz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CE/J

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Dlg4tm1Grnt/Dlg4tm1Grnt,Syngap1tm1Grnt/Syngap1+
Genetic Background: involves: 129P2/OlaHsd * MF1

Allelic Composition: Glb1tm1Jmat/Glb1tm1Jmat
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Glb1tm1Jmat/Glb1tm1Jmat
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Glb1tm1Jmat/Glb1tm1Jmat
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0005277 abnormal brainstem morphology "anomalous structure of the midbrain, pons, or medulla" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82670]
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Allelic Composition: Dlg4tm1Grnt/Dlg4tm1Grnt,Syngap1tm1Grnt/Syngap1+
Genetic Background: involves: 129P2/OlaHsd * MF1

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Glb1tm1Jmat/Glb1tm1Jmat
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0008911 induced hyperactivity "increased physical activity following stimulation such as handling, touching or noise" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Galctwi/Galctwi,Glb1tm1Adz/Glb1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CE/J

 MP:0009640 abnormal renal tubule epithelium morphology "any structural anomaly of the cellular avascular layer of the renal tubule luminar surfaces" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Galctwi/Galctwi,Glb1tm1Adz/Glb1tm1Adz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CE/J

 MP:0010760 abnormal macrophage chemotaxis "anomaly in the movement of a macrophage guided by a specific chemical concentration gradient" [GO:0048246]
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Allelic Composition: Glb1tm1Jmat/Glb1tm1Jmat
Genetic Background: involves: C57BL/6 * CBA * ICR

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000007038 Neu1 / O35657 / neuraminidase 1 / Q99519*  / complex
 ENSMUSG00000017760 Ctsa / P16675 / cathepsin A / P10619*  / complex






 

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