ENSMUSG00000007041


Mus musculus

Features
Gene ID: ENSMUSG00000007041
  
Biological name :Clic1
  
Synonyms : Chloride intracellular channel protein 1 / Clic1 / Q9Z1Q5
  
Possible biological names infered from orthology : chloride intracellular channel 1 / O00299
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: B1
Gene start: 35049966
Gene end: 35058749
  
Corresponding Affymetrix probe sets: 10444658 (MoGene1.0st)   1416656_at (Mouse Genome 430 2.0 Array)   1458665_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000007257
NCBI entrez gene - 114584     See in Manteia.
MGI - MGI:2148924
RefSeq - NM_033444
RefSeq Peptide - NP_254279
swissprot - Q542F1
swissprot - Q9Z1Q5
Ensembl - ENSMUSG00000007041
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 clic1ENSDARG00000103340Danio rerio
 CLIC1ENSG00000213719Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Clic4 / Q9QYB1 / Chloride intracellular channel protein 4 / Q9Y696* / chloride intracellular channel 4*ENSMUSG0000003724265
Clic5 / Q8BXK9 / Chloride intracellular channel protein 5 / Q9NZA1* / chloride intracellular channel 5*ENSMUSG0000002395964
Clic6 / Q8BHB9 / Chloride intracellular channel protein 6 / Q96NY7* / chloride intracellular channel 6*ENSMUSG0000002294963
Clic3 / Q9D7P7 / Chloride intracellular channel protein 3 / O95833* / chloride intracellular channel 3*ENSMUSG0000001509350


Protein motifs (from Interpro)
Interpro ID Name
 IPR002946  Intracellular chloride channel
 IPR004045  Glutathione S-transferase, N-terminal
 IPR010987  Glutathione S-transferase, C-terminal-like
 IPR030259  Chloride intracellular channel protein 1
 IPR036249  Thioredoxin-like superfamily
 IPR036282  Glutathione S-transferase, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006821 chloride transport ISO
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0045669 positive regulation of osteoblast differentiation IDA
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0051881 regulation of mitochondrial membrane potential IMP
 biological_processGO:1902476 chloride transmembrane transport IBA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005635 nuclear envelope IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 cellular_componentGO:0034707 chloride channel complex IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0070062 extracellular exosome IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005254 chloride channel activity IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0045296 cadherin binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0005505 increased platelet count "greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tbc1d32bromi/Tbc1d32Gt(RRF165)Byg
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

 MP:0005606 increased bleeding time "greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Tbc1d32bromi/Tbc1d32Gt(RRF165)Byg
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

 MP:0006298 abnormal platelet activation "anomaly in the series of progressive, overlapping events triggered by exposure of platelets to signals from subendothelial tissue, including shape change, adhesiveness, aggregation, and release reactions; when carried through to completion, these events lead to the formation of a stable hemostatic plug" [GO:0030168, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tbc1d32bromi/Tbc1d32Gt(RRF165)Byg
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

 MP:0009549 impaired platelet aggregation "decrease in the ability of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]
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Allelic Composition: Tbc1d32bromi/Tbc1d32Gt(RRF165)Byg
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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