ENSMUSG00000023959


Mus musculus

Features
Gene ID: ENSMUSG00000023959
  
Biological name :Clic5
  
Synonyms : Chloride intracellular channel protein 5 / Clic5 / Q8BXK9
  
Possible biological names infered from orthology : chloride intracellular channel 5 / Q9NZA1
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: B3
Gene start: 44188572
Gene end: 44280168
  
Corresponding Affymetrix probe sets: 10445347 (MoGene1.0st)   1431261_at (Mouse Genome 430 2.0 Array)   1439505_at (Mouse Genome 430 2.0 Array)   1456873_at (Mouse Genome 430 2.0 Array)   1458381_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000024755
NCBI entrez gene - 224796     See in Manteia.
MGI - MGI:1917912
RefSeq - NM_172621
RefSeq - XM_006524135
RefSeq Peptide - NP_766209
swissprot - Q8BXK9
Ensembl - ENSMUSG00000023959
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 clic5aENSDARG00000075993Danio rerio
 clic5bENSDARG00000070584Danio rerio
 CLIC5ENSGALG00000016707Gallus gallus
 CLIC5ENSG00000112782Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Clic4 / Q9QYB1 / Chloride intracellular channel protein 4 / Q9Y696* / chloride intracellular channel 4*ENSMUSG0000003724274
Clic6 / Q8BHB9 / Chloride intracellular channel protein 6 / Q96NY7* / chloride intracellular channel 6*ENSMUSG0000002294971
Clic1 / Q9Z1Q5 / Chloride intracellular channel protein 1 / O00299* / chloride intracellular channel 1*ENSMUSG0000000704161
Clic3 / Q9D7P7 / Chloride intracellular channel protein 3 / O95833* / chloride intracellular channel 3*ENSMUSG0000001509348


Protein motifs (from Interpro)
Interpro ID Name
 IPR002946  Intracellular chloride channel
 IPR004045  Glutathione S-transferase, N-terminal
 IPR010987  Glutathione S-transferase, C-terminal-like
 IPR030264  Chloride intracellular channel protein 5
 IPR036249  Thioredoxin-like superfamily
 IPR036282  Glutathione S-transferase, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002021 response to dietary excess IMP
 biological_processGO:0002024 diet induced thermogenesis IMP
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006821 chloride transport ISO
 biological_processGO:0007605 sensory perception of sound ISS
 biological_processGO:0008104 protein localization IMP
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0050885 neuromuscular process controlling balance IMP
 biological_processGO:0060088 auditory receptor cell stereocilium organization IMP
 biological_processGO:1902476 chloride transmembrane transport IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0015629 actin cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032420 stereocilium IDA
 cellular_componentGO:0032421 stereocilium bundle IEA
 cellular_componentGO:0034707 chloride channel complex IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005254 chloride channel activity IBA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000043 organ of Corti degeneration "a retrogressive impairment of function or destruction of the highly specialized epithelium in the floor of the ductus cochlearis" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Agtpbp1pcd-6J/Agtpbp1pcd-6J
Genetic Background: C57BL/6J-Agtpbp1pcd-6J/J

Allelic Composition: Clic5jbg/Clic5jbg
Genetic Background: C3H/HeJ-Clic5jbg/J

 MP:0001394 circling "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]
Show

Allelic Composition: Agtpbp1pcd-6J/Agtpbp1pcd-6J
Genetic Background: C57BL/6J-Agtpbp1pcd-6J/J

 MP:0001395 bi-directional circling "circling behavior exhibited in both clockwise and counterclockwise directions" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mafbtm1Jeng/Mafbtm1Jeng
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001410 head bobbing "compulsive up and down movement of the head" [J:17123]
Show

Allelic Composition: Mafbtm1Jeng/Mafbtm1Jeng
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001522 impaired swimming "reduced ability or inability to swim" [J:45446, J:39081]
Show

Allelic Composition: Mafbtm1Jeng/Mafbtm1Jeng
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001967 deafness "inability to hear" [J:57651]
Show

Allelic Composition: Agtpbp1pcd-6J/Agtpbp1pcd-6J
Genetic Background: C57BL/6J-Agtpbp1pcd-6J/J

Allelic Composition: Clic5jbg/Clic5jbg
Genetic Background: C3H/HeJ-Clic5jbg/J

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mafbtm1Jeng/Mafbtm1Jeng
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002857 cochlear ganglion degeneration "loss of neural cell bodies in the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Clic5jbg/Clic5jbg
Genetic Background: C3H/HeJ-Clic5jbg/J

 MP:0004324 vestibular hair cell degeneration "degeneration or loss of the sensory epithelial cells of the maculae and cristae of the membranous labyrinth of the inner ear which are normally in synaptic contact with the vestibular nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clic5jbg/Clic5jbg
Genetic Background: C3H/HeJ-Clic5jbg/J

 MP:0004398 cochlear inner hair cell degeneration "degeneration or loss of the single row of flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clic5jbg/Clic5jbg
Genetic Background: C3H/HeJ-Clic5jbg/J

 MP:0004404 cochlear outer hair cell degeneration "degeneration or loss of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clic5jbg/Clic5jbg
Genetic Background: C3H/HeJ-Clic5jbg/J

 MP:0004521 abnormal cochlear hair cell stereociliary bundle morphology "any structural anomaly or disruption of the typical pattern of arrangement of mechanosensitive hair bundles which are composed of thick long microvilli (stereocilia) and are located at the apical end of cochlear inner and outer hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Agtpbp1pcd-6J/Agtpbp1pcd-6J
Genetic Background: C57BL/6J-Agtpbp1pcd-6J/J

Allelic Composition: Clic5jbg/Clic5jbg
Genetic Background: C3H/HeJ-Clic5jbg/J

 MP:0005307 head tossing "compulsive flailing of the head in multiple directions" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Agtpbp1pcd-6J/Agtpbp1pcd-6J
Genetic Background: C57BL/6J-Agtpbp1pcd-6J/J

 MP:0006359 absent startle reflex "failure to respond to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Agtpbp1pcd-6J/Agtpbp1pcd-6J
Genetic Background: C57BL/6J-Agtpbp1pcd-6J/J

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Agtpbp1pcd-6J/Agtpbp1pcd-6J
Genetic Background: C57BL/6J-Agtpbp1pcd-6J/J

Allelic Composition: Clic5jbg/Clic5jbg
Genetic Background: C3H/HeJ-Clic5jbg/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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