ENSMUSG00000037242


Mus musculus

Features
Gene ID: ENSMUSG00000037242
  
Biological name :Clic4
  
Synonyms : Chloride intracellular channel protein 4 / Clic4 / Q9QYB1
  
Possible biological names infered from orthology : chloride intracellular channel 4 / Q9Y696
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D3
Gene start: 135213969
Gene end: 135272814
  
Corresponding Affymetrix probe sets: 10517336 (MoGene1.0st)   1423392_at (Mouse Genome 430 2.0 Array)   1423393_at (Mouse Genome 430 2.0 Array)   1438606_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000041453
NCBI entrez gene - 29876     See in Manteia.
MGI - MGI:1352754
RefSeq - NM_013885
RefSeq Peptide - NP_038913
swissprot - Q543N5
swissprot - Q9QYB1
Ensembl - ENSMUSG00000037242
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 clic4ENSDARG00000022995Danio rerio
 CLIC4ENSGALG00000001262Gallus gallus
 CLIC4ENSG00000169504Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Clic5 / Q8BXK9 / Chloride intracellular channel protein 5 / Q9NZA1* / chloride intracellular channel 5*ENSMUSG0000002395974
Clic6 / Q8BHB9 / Chloride intracellular channel protein 6 / Q96NY7* / chloride intracellular channel 6*ENSMUSG0000002294972
Clic1 / Q9Z1Q5 / Chloride intracellular channel protein 1 / O00299* / chloride intracellular channel 1*ENSMUSG0000000704162
Clic3 / Q9D7P7 / Chloride intracellular channel protein 3 / O95833* / chloride intracellular channel 3*ENSMUSG0000001509346


Protein motifs (from Interpro)
Interpro ID Name
 IPR002946  Intracellular chloride channel
 IPR010987  Glutathione S-transferase, C-terminal-like
 IPR030257  Chloride intracellular channel protein 4
 IPR036249  Thioredoxin-like superfamily
 IPR036282  Glutathione S-transferase, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0001886 endothelial cell morphogenesis IMP
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006821 chloride transport ISO
 biological_processGO:0007035 vacuolar acidification IMP
 biological_processGO:0009566 fertilization IMP
 biological_processGO:0030216 keratinocyte differentiation IEA
 biological_processGO:0030336 negative regulation of cell migration IEA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0035264 multicellular organism growth IMP
 biological_processGO:0048754 branching morphogenesis of an epithelial tube IMP
 biological_processGO:0061299 retina vasculature morphogenesis in camera-type eye IMP
 biological_processGO:0071277 cellular response to calcium ion IEA
 biological_processGO:1902476 chloride transmembrane transport IBA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005902 microvillus IEA
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0015630 microtubule cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016363 nuclear matrix IEA
 cellular_componentGO:0030496 midbody IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0034707 chloride channel complex IEA
 cellular_componentGO:0045177 apical part of cell IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005254 chloride channel activity IBA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdx1tm3Lhn/Cdx1tm3Lhn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001209 spontaneous skin ulceration "unpredictable appearance of skin lesions, usually with inflammation" [J:65302]
Show

Allelic Composition: Mecp2tm1.1Mitoh/Mecp2tm1.1Mitoh
Genetic Background: Not Specified

Allelic Composition: Clic4tm1.1Yus/Clic4tm1.1Yus
Genetic Background: involves: 129S4/SvJae * C57BL/6J * CD-1 * FVB/N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Cdx1tm3Lhn/Cdx1tm3Lhn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Clic4tm1.1Aidi/Clic4tm1.1Aidi
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0001798 impaired macrophage phagocytosis "reduced ability of these phagocytic cells to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mecp2tm1.1Mitoh/Mecp2tm1.1Mitoh
Genetic Background: Not Specified

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Cdx1tm3Lhn/Cdx1tm3Lhn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mecp2tm1.1Mitoh/Mecp2tm1.1Mitoh
Genetic Background: Not Specified

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Clic4tm1.1Aidi/Clic4tm1.1Aidi
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdx1tm3Lhn/Cdx1tm3Lhn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002908 delayed wound healing "longer time requirement for the ability to self-repair and close wounds than normal" [J:63037]
Show

Allelic Composition: Mecp2tm1.1Mitoh/Mecp2tm1.1Mitoh
Genetic Background: Not Specified

 MP:0003710 abnormal physiological neovascularization "anomalies in the development of new blood vessels in restoration of blood circulation during the healing process " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cdx1tm3Lhn/Cdx1tm3Lhn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0004003 abnormal vascular endothelial cell physiology "anomaly in the function of the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdx1tm3Lhn/Cdx1tm3Lhn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Cdx1tm3Lhn/Cdx1tm3Lhn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0006055 abnormal vascular endothelial cell morphology "malformation in the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdx1tm3Lhn/Cdx1tm3Lhn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0008554 decreased circulating tumor necrosis factor level "reduction in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Clic4tm1.1Aidi/Clic4tm1.1Aidi
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Clic4tm1.1Aidi/Clic4tm1.1Aidi
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0008597 decreased circulating interleukin-6 level "reduction in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Clic4tm1.1Aidi/Clic4tm1.1Aidi
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0008664 decreased interleukin-12 secretion "reduction in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
Show

Allelic Composition: Clic4tm1.1Aidi/Clic4tm1.1Aidi
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Clic4tm1.1Aidi/Clic4tm1.1Aidi
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0008722 abnormal chemokine secretion "anomaly in the production or cellular release of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
Show

Allelic Composition: Clic4tm1.1Aidi/Clic4tm1.1Aidi
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clic4tm1.1Aidi/Clic4tm1.1Aidi
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdx1tm3Lhn/Cdx1tm3Lhn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mecp2tm1.1Mitoh/Mecp2tm1.1Mitoh
Genetic Background: Not Specified

 MP:0009764 decreased sensitivity to induced morbidity/mortality "increase in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clic4tm1.1Aidi/Clic4tm1.1Aidi
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0012194 decreased keratinocyte migration "reduced or slower movement of keratinocyes or their precursors to the appropriate location in the body" [MGI:csmith]
Show

Allelic Composition: Mecp2tm1.1Mitoh/Mecp2tm1.1Mitoh
Genetic Background: Not Specified

 MP:0014122 decreased pancreatic islet cell apoptosis "decrease in the number of pancreatic islet cells undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Clic4tm1.1Thor/Clic4tm1.1Thor,Ins1tm1.1(cre)Thor/Ins1+
Genetic Background: involves: C57BL/6J

 MP:0030578 decreased keratinocyte adhesion "decreased ability of a keratinocyte to adhere to another cell or to a non-cellular component of the environment" [MGI:anna]
Show

Allelic Composition: Mecp2tm1.1Mitoh/Mecp2tm1.1Mitoh
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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