ENSG00000169504


Homo sapiens

Features
Gene ID: ENSG00000169504
  
Biological name :CLIC4
  
Synonyms : chloride intracellular channel 4 / CLIC4 / Q9Y696
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p36.11
Gene start: 24745357
Gene end: 24844324
  
Corresponding Affymetrix probe sets: 201559_s_at (Human Genome U133 Plus 2.0 Array)   201560_at (Human Genome U133 Plus 2.0 Array)   221881_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000363500
Ensembl peptide - ENSP00000436538
NCBI entrez gene - 25932     See in Manteia.
OMIM - 606536
RefSeq - NM_013943
RefSeq Peptide - NP_039234
swissprot - Q6FIC5
swissprot - Q9Y696
Ensembl - ENSG00000169504
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 clic4ENSDARG00000022995Danio rerio
 CLIC4ENSGALG00000001262Gallus gallus
 Clic4ENSMUSG00000037242Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CLIC6 / Q96NY7 / chloride intracellular channel 6ENSG0000015921274
CLIC5 / Q9NZA1 / chloride intracellular channel 5ENSG0000011278273
CLIC1 / O00299 / chloride intracellular channel 1ENSG0000021371964
CLIC2 / O15247 / chloride intracellular channel 2ENSG0000015596262
CLIC3 / O95833 / chloride intracellular channel 3ENSG0000016958346


Protein motifs (from Interpro)
Interpro ID Name
 IPR002946  Intracellular chloride channel
 IPR010987  Glutathione S-transferase, C-terminal-like
 IPR030257  Chloride intracellular channel protein 4
 IPR036249  Thioredoxin-like superfamily
 IPR036282  Glutathione S-transferase, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IBA
 biological_processGO:0001886 endothelial cell morphogenesis IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006821 chloride transport NAS
 biological_processGO:0007035 vacuolar acidification IEA
 biological_processGO:0009566 fertilization IEA
 biological_processGO:0030154 cell differentiation TAS
 biological_processGO:0030216 keratinocyte differentiation IMP
 biological_processGO:0030336 negative regulation of cell migration IDA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0035088 establishment or maintenance of apical/basal cell polarity NAS
 biological_processGO:0035264 multicellular organism growth IEA
 biological_processGO:0048754 branching morphogenesis of an epithelial tube IEA
 biological_processGO:0051493 regulation of cytoskeleton organization NAS
 biological_processGO:0061299 retina vasculature morphogenesis in camera-type eye IEA
 biological_processGO:0071277 cellular response to calcium ion IMP
 biological_processGO:1902476 chloride transmembrane transport IBA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005902 microvillus IDA
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0015629 actin cytoskeleton TAS
 cellular_componentGO:0015630 microtubule cytoskeleton IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016363 nuclear matrix IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030496 midbody IDA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0034707 chloride channel complex IEA
 cellular_componentGO:0045177 apical part of cell IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005254 chloride channel activity IBA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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