ENSMUSG00000008658


Mus musculus

Features
Gene ID: ENSMUSG00000008658
  
Biological name :Rbfox1
  
Synonyms : Q9JJ43 / Rbfox1 / RNA binding 1
  
Possible biological names infered from orthology : Q9NWB1 / RNA binding fox-1 homolog 1
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: A1
Gene start: 5885355
Gene end: 7411526
  
Corresponding Affymetrix probe sets: 10433403 (MoGene1.0st)   1418314_a_at (Mouse Genome 430 2.0 Array)   1438217_at (Mouse Genome 430 2.0 Array)   1447735_x_at (Mouse Genome 430 2.0 Array)   1455358_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000049970
Ensembl peptide - ENSMUSP00000111507
Ensembl peptide - ENSMUSP00000155364
Ensembl peptide - ENSMUSP00000155799
Ensembl peptide - ENSMUSP00000154916
Ensembl peptide - ENSMUSP00000155069
Ensembl peptide - ENSMUSP00000155321
NCBI entrez gene - 268859     See in Manteia.
MGI - MGI:1926224
RefSeq - XM_017317009
RefSeq - NM_021477
RefSeq - NM_183188
RefSeq - XM_017317006
RefSeq - XM_017317007
RefSeq - XM_017317008
RefSeq - XM_006522155
RefSeq - XM_006522173
RefSeq - XM_006522175
RefSeq - XM_006522176
RefSeq - XM_006522177
RefSeq - XM_006522178
RefSeq - XM_006522179
RefSeq - XM_006522181
RefSeq - XM_006522184
RefSeq - XM_006522185
RefSeq - XM_006522186
RefSeq - XM_006522188
RefSeq - XM_006522189
RefSeq - XM_006522190
RefSeq - XM_006522192
RefSeq - XM_011245907
RefSeq - XM_011245909
RefSeq - XM_011245910
RefSeq - XM_011245911
RefSeq - XM_011245912
RefSeq - XM_011245913
RefSeq - XM_011245914
RefSeq - XM_011245915
RefSeq - XM_011245916
RefSeq - XM_011245917
RefSeq - XM_011245918
RefSeq - XM_011245919
RefSeq - XM_011245920
RefSeq - XM_011245922
RefSeq - XM_017316988
RefSeq - XM_017316989
RefSeq - XM_017316990
RefSeq - XM_017316991
RefSeq - XM_017316992
RefSeq - XM_017316993
RefSeq - XM_017316994
RefSeq - XM_017316996
RefSeq - XM_017316997
RefSeq - XM_017316998
RefSeq - XM_017316999
RefSeq - XM_017317000
RefSeq - XM_017317002
RefSeq - XM_017317003
RefSeq - XM_017317004
RefSeq - XM_017317005
RefSeq Peptide - NP_899011
RefSeq Peptide - NP_067452
swissprot - Q9JJ43
Ensembl - ENSMUSG00000008658
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q642J5ENSDARG00000014746Danio rerio
 RBFOX1ENSGALG00000034325Gallus gallus
 Q9NWB1ENSG00000078328Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8BP71 / Rbfox2 / Mus musculus RNA binding protein, fox-1 homolog (C. elegans) 2 (Rbfox2), transcript variant 10, mRNA. / O43251* / RNA binding fox-1 homolog 2*ENSMUSG0000003356559
Q8BIF2 / Rbfox3 / RNA binding 3 / A6NFN3* / RNA binding fox-1 homolog 3*ENSMUSG0000002557654


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR017325  RNA binding protein Fox-1
 IPR025670  Fox-1 C-terminal domain
 IPR034237  FOX1, RNA recognition motif
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000381 regulation of alternative mRNA splicing, via spliceosome IMP
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0007399 nervous system development IBA
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0043484 regulation of RNA splicing IEA
 biological_processGO:0050885 neuromuscular process controlling balance IGI
 biological_processGO:2001014 regulation of skeletal muscle cell differentiation IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005802 trans-Golgi network ISO
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003729 mRNA binding IBA
 molecular_functionGO:0008022 protein C-terminus binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
Show

Allelic Composition: Rbfox1tm1.1Dblk/Rbfox1+,Rbfox2tm1.1Dblk/Rbfox2tm1.1Dblk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL

 MP:0000885 ectopic Purkinje cell "Purkinje cell body resides in places other than the Purkinje cell layer in the cerebellum" [MGI:tc, J:60896]
Show

Allelic Composition: Rbfox1tm1.1Dblk/Rbfox1+,Rbfox2tm1.1Dblk/Rbfox2tm1.1Dblk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Pax3tm6(Pax8)Buck/Pax3+
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Rbfox1tm1.1Dblk/Rbfox1+,Rbfox2tm1.1Dblk/Rbfox2tm1.1Dblk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Rbfox1tm1.1Dblk/Rbfox1+,Rbfox2tm1.1Dblk/Rbfox2tm1.1Dblk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Rbfox1tm1.1Dblk/Rbfox1+,Rbfox2tm1.1Dblk/Rbfox2tm1.1Dblk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
Show

Allelic Composition: Pax3tm6(Pax8)Buck/Pax3+
Genetic Background: involves: 129S2/SvPas

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pax3tm6(Pax8)Buck/Pax3+
Genetic Background: involves: 129S2/SvPas

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
Show

Allelic Composition: Pax3tm6(Pax8)Buck/Pax3+
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Rbfox1tm1.1Dblk/Rbfox1+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * C57BL/6J * SJL

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Pax3tm6(Pax8)Buck/Pax3+
Genetic Background: involves: 129S2/SvPas

 MP:0003997 tonic-clonic seizures "increased number or decreased threshold for the induction of a seizure characterized by initial rigidity followed by rhythmic jerking movements" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Pax3tm6(Pax8)Buck/Pax3+
Genetic Background: involves: 129S2/SvPas

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Rbfox1tm1.1Dblk/Rbfox1+,Rbfox2tm1.1Dblk/Rbfox2tm1.1Dblk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Rbfox1tm1.1Dblk/Rbfox1tm1.1Dblk,Rbfox2tm1.1Dblk/Rbfox2tm1.1Dblk,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129 * C57BL/6J

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pax3tm6(Pax8)Buck/Pax3+
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Rbfox1tm1.1Dblk/Rbfox1+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * C57BL/6J * SJL

 MP:0009936 abnormal dendritic spine morphology "any structural anomaly of the small membranous protrusion from the dendrite of a neuron that is involved in synaptic transmission; it typically receives input from a single synapse of an axon" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pax3tm6(Pax8)Buck/Pax3+
Genetic Background: involves: 129S2/SvPas

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Rbfox1tm1.1Dblk/Rbfox1+,Rbfox2tm1.1Dblk/Rbfox2tm1.1Dblk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Atp7a+/Atp7aMo-5J
Genetic Background: involves: C57BL/6J * DBA/2J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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