ENSMUSG00000033565


Mus musculus

Features
Gene ID: ENSMUSG00000033565
  
Biological name :Rbfox2
  
Synonyms : Mus musculus RNA binding protein, fox-1 homolog (C. elegans) 2 (Rbfox2), transcript variant 10, mRNA. / Q8BP71 / Rbfox2
  
Possible biological names infered from orthology : O43251 / RNA binding fox-1 homolog 2
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: D3
Gene start: 77078990
Gene end: 77307004
  
Corresponding Affymetrix probe sets: 10430145 (MoGene1.0st)   1418245_a_at (Mouse Genome 430 2.0 Array)   1418246_at (Mouse Genome 430 2.0 Array)   1418247_s_at (Mouse Genome 430 2.0 Array)   1434938_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000048056
Ensembl peptide - ENSMUSP00000129372
Ensembl peptide - ENSMUSP00000130673
Ensembl peptide - ENSMUSP00000130739
Ensembl peptide - ENSMUSP00000153751
Ensembl peptide - ENSMUSP00000154021
Ensembl peptide - ENSMUSP00000154209
Ensembl peptide - ENSMUSP00000154233
Ensembl peptide - ENSMUSP00000154408
Ensembl peptide - ENSMUSP00000154522
Ensembl peptide - ENSMUSP00000154719
Ensembl peptide - ENSMUSP00000154810
NCBI entrez gene - 93686     See in Manteia.
MGI - MGI:1933973
RefSeq - XM_017316812
RefSeq - NM_001110827
RefSeq - NM_001110828
RefSeq - NM_001110829
RefSeq - NM_001110830
RefSeq - NM_001286417
RefSeq - NM_001286418
RefSeq - NM_001286419
RefSeq - NM_001358770
RefSeq - NM_053104
RefSeq - NM_175387
RefSeq - XM_006521584
RefSeq - XM_006521586
RefSeq - XM_006521587
RefSeq - XM_006521588
RefSeq - XM_006521592
RefSeq - XM_006521593
RefSeq - XM_006521598
RefSeq - XM_006521599
RefSeq - XM_017316809
RefSeq - XM_017316810
RefSeq - XM_017316811
RefSeq - XM_006521564
RefSeq - XM_006521565
RefSeq - XM_006521566
RefSeq - XM_006521567
RefSeq - XM_006521568
RefSeq - XM_006521569
RefSeq - XM_006521570
RefSeq - XM_006521571
RefSeq - XM_006521574
RefSeq - XM_006521576
RefSeq - XM_006521577
RefSeq - XM_006521578
RefSeq - XM_006521579
RefSeq - XM_006521580
RefSeq - XM_006521583
RefSeq Peptide - NP_001104297
RefSeq Peptide - NP_001104299
RefSeq Peptide - NP_001104300
RefSeq Peptide - NP_001273346
RefSeq Peptide - NP_001273347
RefSeq Peptide - NP_001273348
RefSeq Peptide - NP_001345699
RefSeq Peptide - NP_444334
RefSeq Peptide - NP_780596
RefSeq Peptide - NP_001104298
swissprot - Q8BP71
Ensembl - ENSMUSG00000033565
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rbfox2ENSDARG00000052182Danio rerio
 RBFOX2ENSGALG00000012540Gallus gallus
 O43251ENSG00000100320Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9JJ43 / Rbfox1 / RNA binding 1 / Q9NWB1* / RNA binding fox-1 homolog 1*ENSMUSG0000000865855
Q8BIF2 / Rbfox3 / RNA binding 3 / A6NFN3* / RNA binding fox-1 homolog 3*ENSMUSG0000002557649


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR017325  RNA binding protein Fox-1
 IPR025670  Fox-1 C-terminal domain
 IPR034237  FOX1, RNA recognition motif
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000381 regulation of alternative mRNA splicing, via spliceosome IMP
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0010724 regulation of definitive erythrocyte differentiation IDA
 biological_processGO:0021942 radial glia guided migration of Purkinje cell IMP
 biological_processGO:0030520 intracellular estrogen receptor signaling pathway ISO
 biological_processGO:0043484 regulation of RNA splicing IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISS
 biological_processGO:0048813 dendrite morphogenesis IMP
 biological_processGO:0050885 neuromuscular process controlling balance IGI
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol ISO
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003714 transcription corepressor activity ISO
 molecular_functionGO:0003723 RNA binding ISO
 molecular_functionGO:0003729 mRNA binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding ISS


Pathways (from Reactome)
Pathway description
FGFR2 alternative splicing


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
Show

Allelic Composition: Rbfox1tm1.1Dblk/Rbfox1+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Rbfox1tm1.1Dblk/Rbfox1+,Rbfox2tm1.1Dblk/Rbfox2tm1.1Dblk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL

 MP:0000879 increased Purkinje cell number "greater than normal number of neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rbfox1tm1.1Dblk/Rbfox1+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * C57BL/6J * SJL

 MP:0000885 ectopic Purkinje cell "Purkinje cell body resides in places other than the Purkinje cell layer in the cerebellum" [MGI:tc, J:60896]
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Allelic Composition: Rbfox1tm1.1Dblk/Rbfox1+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Rbfox1tm1.1Dblk/Rbfox1+,Rbfox2tm1.1Dblk/Rbfox2tm1.1Dblk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL

 MP:0000890 thin cerebellar molecular layer "reduced width of the outer of the three cortical layers of the cerebellum" [J:46854]
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Allelic Composition: Rbfox1tm1.1Dblk/Rbfox1+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * C57BL/6J * SJL

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Rbfox1tm1.1Dblk/Rbfox1+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * C57BL/6J * SJL

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Atp7a+/Atp7aMo-5J
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Rbfox1tm1.1Dblk/Rbfox1+,Rbfox2tm1.1Dblk/Rbfox2tm1.1Dblk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Rbfox1tm1.1Dblk/Rbfox1+,Rbfox2tm1.1Dblk/Rbfox2tm1.1Dblk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
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Allelic Composition: Rbfox1tm1.1Dblk/Rbfox1+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * C57BL/6J * SJL

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Rbfox1tm1.1Dblk/Rbfox1+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * C57BL/6J * SJL

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Rbfox1tm1.1Dblk/Rbfox1+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * C57BL/6J * SJL

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rbfox1tm1.1Dblk/Rbfox1+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * C57BL/6J * SJL

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Rbfox1tm1.1Dblk/Rbfox1+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Rbfox1tm1.1Dblk/Rbfox1+,Rbfox2tm1.1Dblk/Rbfox2tm1.1Dblk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Rbfox1tm1.1Dblk/Rbfox1tm1.1Dblk,Rbfox2tm1.1Dblk/Rbfox2tm1.1Dblk,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129 * C57BL/6J

 MP:0010008 abnormal Purkinje cell migration "defective or impaired movement of immature Purkinje cells from the ventricular zone of the fourth ventricle to the forming Purkinje cell layer during development of the cerebellar cortex" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rbfox1tm1.1Dblk/Rbfox1+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * C57BL/6J * SJL

 MP:0010831 partial lethality "the appearance of lower than Mendelian ratios of offspring of a given genotype due to death of some, but not all of the organisms" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rbfox1tm1.1Dblk/Rbfox1+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * C57BL/6J * SJL

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Rbfox1tm1.1Dblk/Rbfox1+,Rbfox2tm1.1Dblk/Rbfox2tm1.1Dblk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Rbfox1tm1.1Dblk/Rbfox1+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * C57BL/6J * SJL

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Atp7a+/Atp7aMo-5J
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0013551 decreased cerebellar granule cell precursor proliferation "reduction in the ability of a cerebellar granule cell precursor population to undergo rapid expansion by cell division" [MGI:csmith]
Show

Allelic Composition: Rbfox1tm1.1Dblk/Rbfox1+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * C57BL/6J * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000042079 Hnrnpf / Q9Z2X1 / Heteroous nuclear ribonucleoprotein F Heteroous nuclear ribonucleoprotein F, N-terminally processed / P52597* / heterogeneous nuclear ribonucleoprotein F*  / complex
 ENSMUSG00000007850 O35737 / Hnrnph1 / Mus musculus heteroous nuclear ribonucleoprotein H1 (Hnrnph1), transcript variant 1, mRNA. / P31943* / heterogeneous nuclear ribonucleoprotein H1*  / complex






 

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