ENSMUSG00000016382


Mus musculus

Features
Gene ID: ENSMUSG00000016382
  
Biological name :Pls3
  
Synonyms : Mus musculus plastin 3 (T-isoform) (Pls3), transcript variant 4, mRNA. / Pls3 / Q99K51
  
Possible biological names infered from orthology : P13797 / plastin 3
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: A7.3
Gene start: 75785654
Gene end: 75875182
  
Corresponding Affymetrix probe sets: 10605437 (MoGene1.0st)   1423725_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033547
Ensembl peptide - ENSMUSP00000109692
Ensembl peptide - ENSMUSP00000109693
Ensembl peptide - ENSMUSP00000118995
Ensembl peptide - ENSMUSP00000109691
NCBI entrez gene - 102866     See in Manteia.
MGI - MGI:104807
RefSeq - XM_006527734
RefSeq - NM_001166453
RefSeq - NM_001166454
RefSeq - NM_001346519
RefSeq - NM_001346520
RefSeq - NM_145629
RefSeq - XM_006527731
RefSeq - XM_006527732
RefSeq - XM_006527733
RefSeq Peptide - NP_001333449
RefSeq Peptide - NP_001159925
RefSeq Peptide - NP_001159926
RefSeq Peptide - NP_663604
RefSeq Peptide - NP_001333448
swissprot - Q99K51
swissprot - B1AX58
swissprot - A0A1C7CYV0
Ensembl - ENSMUSG00000016382
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pls3ENSDARG00000037655Danio rerio
 PLS3ENSGALG00000005930Gallus gallus
 PLS3ENSG00000102024Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lcp1 / Q61233 / Plastin-2 / P13796* / lymphocyte cytosolic protein 1*ENSMUSG0000002199878
Pls1 / Q3V0K9 / Plastin-1 / Q14651*ENSMUSG0000004949374


Protein motifs (from Interpro)
Interpro ID Name
 IPR001589  Actinin-type actin-binding domain, conserved site
 IPR001715  Calponin homology domain
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site
 IPR036872  CH domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0051017 actin filament bundle assembly IBA
 biological_processGO:0051639 actin filament network formation IBA
 biological_processGO:0051764 actin crosslink formation IBA
 biological_processGO:0060348 bone development ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005884 actin filament IBA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0032432 actin filament bundle IBA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051015 actin filament binding IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Pitx3tm1.1(KOMP)Vlcg/Pitx3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Pitx3tm1.1(KOMP)Vlcg/J

 MP:0000223 decreased monocyte count "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pitx3tm1.1(KOMP)Vlcg/Pitx3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Pitx3tm1.1(KOMP)Vlcg/J

 MP:0001566 hyperphosphatemia "abnormally high concentrations of phosphates in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pfn1tm1a(EUCOMM)Wtsi/Pfn1+
Genetic Background: B6Brd;B6Dnk;B6N-Tyrc-Brd Pfn1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pfn1tm1a(EUCOMM)Wtsi/Pfn1+
Genetic Background: B6Brd;B6Dnk;B6N-Tyrc-Brd Pfn1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pitx3tm1.1(KOMP)Vlcg/Pitx3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Pitx3tm1.1(KOMP)Vlcg/J

 MP:0005554 decreased circulating creatinine level "less than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Pfn1tm1a(EUCOMM)Wtsi/Pfn1+
Genetic Background: B6Brd;B6Dnk;B6N-Tyrc-Brd Pfn1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0010052 increased grip strength "greater ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Pfn1tm1a(EUCOMM)Wtsi/Pfn1+
Genetic Background: B6Brd;B6Dnk;B6N-Tyrc-Brd Pfn1tm1a(EUCOMM)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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