ENSMUSG00000021998


Mus musculus

Features
Gene ID: ENSMUSG00000021998
  
Biological name :Lcp1
  
Synonyms : Lcp1 / Plastin-2 / Q61233
  
Possible biological names infered from orthology : lymphocyte cytosolic protein 1 / P13796
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: D3
Gene start: 75131101
Gene end: 75230842
  
Corresponding Affymetrix probe sets: 10416437 (MoGene1.0st)   1415983_at (Mouse Genome 430 2.0 Array)   1448160_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000117137
Ensembl peptide - ENSMUSP00000117984
Ensembl peptide - ENSMUSP00000121376
Ensembl peptide - ENSMUSP00000121201
Ensembl peptide - ENSMUSP00000118721
Ensembl peptide - ENSMUSP00000116033
Ensembl peptide - ENSMUSP00000116271
NCBI entrez gene - 18826     See in Manteia.
MGI - MGI:104808
RefSeq - XM_006518701
RefSeq - XM_006518699
RefSeq - XM_006518704
RefSeq - XM_006518703
RefSeq - NM_001247984
RefSeq - NM_008879
RefSeq - XM_017315920
RefSeq - XM_006518702
RefSeq Peptide - NP_032905
RefSeq Peptide - NP_001234913
swissprot - Q61233
swissprot - D3Z7D9
swissprot - D3YVW8
swissprot - D3YZ25
swissprot - D3Z311
Ensembl - ENSMUSG00000021998
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lcp1ENSDARG00000023188Danio rerio
 LCP1ENSGALG00000016986Gallus gallus
 LCP1ENSG00000136167Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pls3 / Q99K51 / Mus musculus plastin 3 (T-isoform) (Pls3), transcript variant 4, mRNA. / P13797* / plastin 3*ENSMUSG0000001638280
Pls1 / Q3V0K9 / Plastin-1 / Q14651*ENSMUSG0000004949374


Protein motifs (from Interpro)
Interpro ID Name
 IPR001589  Actinin-type actin-binding domain, conserved site
 IPR001715  Calponin homology domain
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site
 IPR036872  CH domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002286 T cell activation involved in immune response ISS
 biological_processGO:0009611 response to wounding ISO
 biological_processGO:0010737 protein kinase A signaling ISO
 biological_processGO:0016477 cell migration ISO
 biological_processGO:0022617 extracellular matrix disassembly ISO
 biological_processGO:0031100 animal organ regeneration IEA
 biological_processGO:0033157 regulation of intracellular protein transport ISS
 biological_processGO:0051017 actin filament bundle assembly ISO
 biological_processGO:0051639 actin filament network formation IBA
 biological_processGO:0051764 actin crosslink formation IBA
 biological_processGO:0071803 positive regulation of podosome assembly ISO
 cellular_componentGO:0001725 stress fiber ISO
 cellular_componentGO:0001726 ruffle ISO
 cellular_componentGO:0001891 phagocytic cup IDA
 cellular_componentGO:0002102 podosome ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005884 actin filament ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005925 focal adhesion ISO
 cellular_componentGO:0015629 actin cytoskeleton ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030175 filopodium ISO
 cellular_componentGO:0032432 actin filament bundle IBA
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISO
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005178 integrin binding ISO
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051015 actin filament binding ISO
 molecular_functionGO:0051020 GTPase binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Relbtm1Brv/Relbtm1Brv
Genetic Background: involves: 129S2/SvPas

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Relbtm1Brv/Relbtm1Brv
Genetic Background: involves: 129S2/SvPas

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Relbtm1Brv/Relbtm1Brv
Genetic Background: involves: 129S2/SvPas

 MP:0008652 decreased interleukin-1 secretion "reduction in the production or release of a soluble factor produced by monocytes, macrophages and other cells, which activates T-lymphocytes and potentiates their response to mitogens or antigens" [MESH:D12.644.276.374.465.501]
Show

Allelic Composition: Relbtm1Brv/Relbtm1Brv
Genetic Background: involves: 129S2/SvPas

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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