ENSMUSG00000049493


Mus musculus

Features
Gene ID: ENSMUSG00000049493
  
Biological name :Pls1
  
Synonyms : Plastin-1 / Pls1 / Q3V0K9
  
Possible biological names infered from orthology : Q14651
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: E3.3
Gene start: 95752642
Gene end: 95845311
  
Corresponding Affymetrix probe sets: 10595768 (MoGene1.0st)   1460406_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000091317
Ensembl peptide - ENSMUSP00000113200
NCBI entrez gene - 102502     See in Manteia.
MGI - MGI:104809
RefSeq - XM_006510748
RefSeq - NM_001033210
RefSeq - XM_006510746
RefSeq - XM_006510747
RefSeq Peptide - NP_001028382
swissprot - D3Z6J7
swissprot - Q3V0K9
Ensembl - ENSMUSG00000049493
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pls1ENSDARG00000039272Danio rerio
 PLS1ENSGALG00000002647Gallus gallus
 PLS1ENSG00000120756Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pls3 / Q99K51 / Mus musculus plastin 3 (T-isoform) (Pls3), transcript variant 4, mRNA. / P13797* / plastin 3*ENSMUSG0000001638275
Lcp1 / Q61233 / Plastin-2 / P13796* / lymphocyte cytosolic protein 1*ENSMUSG0000002199873


Protein motifs (from Interpro)
Interpro ID Name
 IPR001589  Actinin-type actin-binding domain, conserved site
 IPR001715  Calponin homology domain
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site
 IPR030235  Plastin-1
 IPR036872  CH domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001951 intestinal D-glucose absorption IGI
 biological_processGO:0032532 regulation of microvillus length IGI
 biological_processGO:0040018 positive regulation of multicellular organism growth IGI
 biological_processGO:0051017 actin filament bundle assembly IBA
 biological_processGO:0051639 actin filament network formation IBA
 biological_processGO:0051764 actin crosslink formation IBA
 biological_processGO:1902896 terminal web assembly IMP
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005884 actin filament IBA
 cellular_componentGO:0005903 brush border IDA
 cellular_componentGO:0032432 actin filament bundle IBA
 cellular_componentGO:1990357 terminal web IDA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000488 abnormal intestinal epithelium morphology "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mc4rtm2Lowl/Mc4rtm2Lowl,Tg(Sim1-cre)1Lowl/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0004431 abnormal hair cell mechanoelectric transduction "anomalous conversion of mechanical energy into electric(al) energy by sensory cells, such as auditory and vestibular hair cells, required for auditory sensation" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mc4rtm2Lowl/Mc4rtm2Lowl,Tg(Sim1-cre)1Lowl/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0004525 thin cochlear hair cell stereocilia "reduced thickness of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on cochlear inner and outer hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mc4rtm2Lowl/Mc4rtm2Lowl,Tg(Sim1-cre)1Lowl/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0004527 abnormal outer hair cell stereociliary bundle morphology "any structural anomaly or disruption of the typical V or W-like pattern of arrangement of mechanosensitive hair bundles located at the apical end of cochlear OHCs; each hair bundle is normally composed of ~100 nonmotile, actin-filled microvilli (stereocilia) arranged in rows of increasing height and coupled to one another by morphologically distinct links: tip links, horizontal top connectors, shaft connectors, and ankle links; most hair bundles also possess a single motile kinocilium immediately adjacent to the tallest (outermost) row of stereocilia; a fifth link type, the kinocilial link, connects the kinocilium to its neighboring stereocilia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mc4rtm2Lowl/Mc4rtm2Lowl,Tg(Sim1-cre)1Lowl/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0004528 fused outer hair cell stereocilia "coalescence of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on cochlear outer hair cells, often resulting in giant stereocilia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mc4rtm2Lowl/Mc4rtm2Lowl,Tg(Sim1-cre)1Lowl/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0004532 abnormal inner hair cell stereociliary bundle morphology "any structural anomaly or disruption of the typically linear or U-shaped pattern of arrangement of mechanosensitive hair bundles located at the apical end of cochlear IHCs; each hair bundle is normally composed of ~100 nonmotile, actin-filled microvilli (stereocilia) arranged in rows of increasing height and coupled to one another by morphologically distinct links: tip links, horizontal top connectors, shaft connectors, and ankle links; most hair bundles also possess a single motile kinocilium immediately adjacent to the tallest row of stereocilia; a fifth link type, the kinocilial link, connects the kinocilium to its neighboring stereocilia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mc4rtm2Lowl/Mc4rtm2Lowl,Tg(Sim1-cre)1Lowl/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0004534 decreased inner hair cell stereocilia number "decreased number (or less than the expected 100 or so) of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on cochlear inner hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mc4rtm2Lowl/Mc4rtm2Lowl,Tg(Sim1-cre)1Lowl/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0004536 short inner hair cell stereocilia "reduced length of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on cochlear inner hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mc4rtm2Lowl/Mc4rtm2Lowl,Tg(Sim1-cre)1Lowl/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0006325 impaired hearing "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mc4rtm2Lowl/Mc4rtm2Lowl,Tg(Sim1-cre)1Lowl/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0008141 decreased small intestinal microvillus size "reduced size of the additional extensions of the villi of the small intestine which protrude from the apical surface of the epithelial cells lining the villi; the microvilli increase the absorptive surface area of the small intestine by approximately 600-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mc4rtm2Lowl/Mc4rtm2Lowl,Tg(Sim1-cre)1Lowl/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mc4rtm2Lowl/Mc4rtm2Lowl,Tg(Sim1-cre)1Lowl/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0008885 increased enterocyte apoptosis "increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mc4rtm2Lowl/Mc4rtm2Lowl,Tg(Sim1-cre)1Lowl/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0010155 abnormal intestine physiology "any functional anomaly of the digestive tube passing from the stomach to the anus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mc4rtm2Lowl/Mc4rtm2Lowl,Tg(Sim1-cre)1Lowl/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Mc4rtm2Lowl/Mc4rtm2Lowl,Tg(Sim1-cre)1Lowl/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0013298 increased susceptibility to colitis induced morbidity/mortality " increased likelihood that an organism will display the expected moribund state caused by colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:Annie_Speak]
Show

Allelic Composition: Mc4rtm2Lowl/Mc4rtm2Lowl,Tg(Sim1-cre)1Lowl/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr