ENSG00000136167


Homo sapiens

Features
Gene ID: ENSG00000136167
  
Biological name :LCP1
  
Synonyms : LCP1 / lymphocyte cytosolic protein 1 / P13796
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 13
Strand: -1
Band: q14.13
Gene start: 46125920
Gene end: 46211871
  
Corresponding Affymetrix probe sets: 208885_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000402157
Ensembl peptide - ENSP00000408052
Ensembl peptide - ENSP00000315757
Ensembl peptide - ENSP00000381581
NCBI entrez gene - 3936     See in Manteia.
OMIM - 153430
RefSeq - NM_002298
RefSeq - XM_005266374
RefSeq Peptide - NP_002289
swissprot - Q5TBN5
swissprot - P13796
swissprot - A0A024RDT4
swissprot - Q5TBN3
Ensembl - ENSG00000136167
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lcp1ENSDARG00000023188Danio rerio
 LCP1ENSGALG00000016986Gallus gallus
 Lcp1ENSMUSG00000021998Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PLS3 / P13797 / plastin 3ENSG0000010202480
PLS1 / Q14651 / plastin 1ENSG0000012075673


Protein motifs (from Interpro)
Interpro ID Name
 IPR001589  Actinin-type actin-binding domain, conserved site
 IPR001715  Calponin homology domain
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site
 IPR036872  CH domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002286 T cell activation involved in immune response IDA
 biological_processGO:0010737 protein kinase A signaling IMP
 biological_processGO:0016477 cell migration IMP
 biological_processGO:0022617 extracellular matrix disassembly IMP
 biological_processGO:0031100 animal organ regeneration IEA
 biological_processGO:0033157 regulation of intracellular protein transport IDA
 biological_processGO:0035722 interleukin-12-mediated signaling pathway TAS
 biological_processGO:0051017 actin filament bundle assembly IMP
 biological_processGO:0051639 actin filament network formation IBA
 biological_processGO:0051764 actin crosslink formation IBA
 biological_processGO:0071803 positive regulation of podosome assembly IMP
 cellular_componentGO:0001725 stress fiber IMP
 cellular_componentGO:0001726 ruffle IMP
 cellular_componentGO:0001891 phagocytic cup IEA
 cellular_componentGO:0002102 podosome IDA
 cellular_componentGO:0005615 extracellular space HDA
 cellular_componentGO:0005737 cytoplasm NAS
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005884 actin filament IMP
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005925 focal adhesion IMP
 cellular_componentGO:0015629 actin cytoskeleton IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction TAS
 cellular_componentGO:0030175 filopodium IMP
 cellular_componentGO:0032432 actin filament bundle IMP
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005178 integrin binding IPI
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051015 actin filament binding IMP
 molecular_functionGO:0051020 GTPase binding IPI


Pathways (from Reactome)
Pathway description
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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