ENSMUSG00000016664


Mus musculus

Features
Gene ID: ENSMUSG00000016664
  
Biological name :Pacsin2
  
Synonyms : Pacsin2 / protein kinase C and casein kinase substrate in neurons 2 / Q9WVE8
  
Possible biological names infered from orthology : Q9UNF0
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: E1
Gene start: 83375607
Gene end: 83464606
  
Corresponding Affymetrix probe sets: 10430997 (MoGene1.0st)   1417810_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000058320
Ensembl peptide - ENSMUSP00000130098
Ensembl peptide - ENSMUSP00000131504
Ensembl peptide - ENSMUSP00000155068
Ensembl peptide - ENSMUSP00000155481
Ensembl peptide - ENSMUSP00000155845
Ensembl peptide - ENSMUSP00000155333
Ensembl peptide - ENSMUSP00000155334
NCBI entrez gene - 23970     See in Manteia.
MGI - MGI:1345153
RefSeq - XM_017316605
RefSeq - NM_001159509
RefSeq - NM_001159510
RefSeq - NM_001358641
RefSeq - NM_011862
RefSeq - XM_006520980
RefSeq - XM_006520981
RefSeq - XM_006520982
RefSeq - XM_006520983
RefSeq - XM_006520984
RefSeq - XM_006520985
RefSeq - XM_011245633
RefSeq - XM_006520979
RefSeq Peptide - NP_001345570
RefSeq Peptide - NP_035992
RefSeq Peptide - NP_001152981
RefSeq Peptide - NP_001152982
swissprot - Q3TDA7
swissprot - Q3UP40
swissprot - Q9WVE8
Ensembl - ENSMUSG00000016664
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pacsin2ENSDARG00000078014Danio rerio
 PACSIN2ENSGALG00000014159Gallus gallus
 Q9UNF0ENSG00000100266Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q61644 / Pacsin1 / Protein kinase C and casein kinase substrate in neurons protein 1 / Q9BY11* / protein kinase C and casein kinase substrate in neurons 1*ENSMUSG0000004027662
Q99JB8 / Pacsin3 / Protein kinase C and casein kinase II substrate protein 3 / Q9UKS6* / protein kinase C and casein kinase substrate in neurons 3*ENSMUSG0000002725750


Protein motifs (from Interpro)
Interpro ID Name
 IPR001060  FCH domain
 IPR001452  SH3 domain
 IPR027267  AH/BAR domain superfamily
 IPR028521  Protein kinase C and casein kinase substrate in neurons protein 2
 IPR031160  F-BAR domain
 IPR035743  PACSIN1/PACSIN2, SH3 domain
 IPR036028  SH3-like domain superfamily
 IPR037453  PACSIN2, F-BAR domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0036010 protein localization to endosome IEA
 biological_processGO:0045806 negative regulation of endocytosis IDA
 biological_processGO:0048858 cell projection morphogenesis IMP
 biological_processGO:0070836 caveola assembly ISS
 biological_processGO:0072584 caveolin-mediated endocytosis IEA
 biological_processGO:0097320 plasma membrane tubulation ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IBA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005901 caveola ISO
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0019898 extrinsic component of membrane IDA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0055038 recycling endosome membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008092 cytoskeletal protein binding IDA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0045296 cadherin binding IEA
 molecular_functionGO:0070300 phosphatidic acid binding IEA


Pathways (from Reactome)
Pathway description
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002591 decreased mean corpuscular volume "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Otub1tm1b(EUCOMM)Hmgu/Otub1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Otub1tm1b(EUCOMM)Hmgu/H

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Otub1tm1b(EUCOMM)Hmgu/Otub1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Otub1tm1b(EUCOMM)Hmgu/H

 MP:0005562 decreased mean corpuscular hemoglobin "less than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Otub1tm1b(EUCOMM)Hmgu/Otub1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Otub1tm1b(EUCOMM)Hmgu/H

 MP:0005642 decreased mean corpuscular hemoglobin concentration "less than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:8936]
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Allelic Composition: Otub1tm1b(EUCOMM)Hmgu/Otub1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Otub1tm1b(EUCOMM)Hmgu/H

 MP:0010571 shortened ST segment "reduction in the length of time between the end of S-wave and the beginning of T-wave; reflects the amount of time the ventricles remain electrically depolarized" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Otub1tm1b(EUCOMM)Hmgu/Otub1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Otub1tm1b(EUCOMM)Hmgu/H

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Otub1tm1b(EUCOMM)Hmgu/Otub1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Otub1tm1b(EUCOMM)Hmgu/H

 MP:0011968 decreased threshold for auditory brainstem response "reduction in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system" [MGI:csmith]
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Allelic Composition: Otub1tm1b(EUCOMM)Hmgu/Otub1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Otub1tm1b(EUCOMM)Hmgu/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000016664 Q9WVE8 / Pacsin2 / protein kinase C and casein kinase substrate in neurons 2 / Q9UNF0*  / complex






 

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