ENSG00000100266


Homo sapiens

Features
Gene ID: ENSG00000100266
  
Biological name :PACSIN2
  
Synonyms : PACSIN2 / protein kinase C and casein kinase substrate in neurons 2 / Q9UNF0
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 22
Strand: -1
Band: q13.2
Gene start: 42835412
Gene end: 43015145
  
Corresponding Affymetrix probe sets: 1554691_a_at (Human Genome U133 Plus 2.0 Array)   201651_s_at (Human Genome U133 Plus 2.0 Array)   233705_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000398573
Ensembl peptide - ENSP00000396816
Ensembl peptide - ENSP00000399953
Ensembl peptide - ENSP00000489297
Ensembl peptide - ENSP00000422788
Ensembl peptide - ENSP00000403435
Ensembl peptide - ENSP00000263246
Ensembl peptide - ENSP00000338379
Ensembl peptide - ENSP00000385040
Ensembl peptide - ENSP00000385372
Ensembl peptide - ENSP00000385952
NCBI entrez gene - 11252     See in Manteia.
OMIM - 604960
RefSeq - XM_017028568
RefSeq - NM_007229
RefSeq - XM_005261319
RefSeq - XM_011529846
RefSeq - XM_011529847
RefSeq - XM_011529848
RefSeq - XM_011529849
RefSeq - XM_011529850
RefSeq - XM_011529851
RefSeq - XM_011529852
RefSeq - XM_011529853
RefSeq - XM_017028562
RefSeq - XM_017028563
RefSeq - XM_017028564
RefSeq - XM_017028565
RefSeq - XM_017028566
RefSeq - XM_017028567
RefSeq - NM_001184970
RefSeq - NM_001184971
RefSeq - NM_001349969
RefSeq - NM_001349970
RefSeq - NM_001349971
RefSeq - NM_001349972
RefSeq - NM_001349973
RefSeq - NM_001349974
RefSeq Peptide - NP_001336898
RefSeq Peptide - NP_001336900
RefSeq Peptide - NP_001336901
RefSeq Peptide - NP_001336902
RefSeq Peptide - NP_001336903
RefSeq Peptide - NP_009160
RefSeq Peptide - NP_001171899
RefSeq Peptide - NP_001171900
RefSeq Peptide - NP_001336899
swissprot - B0QYG8
swissprot - B0QYG7
swissprot - H0Y923
swissprot - A0A0U1RR22
swissprot - B0QYG9
swissprot - Q6FIA3
swissprot - Q9UNF0
Ensembl - ENSG00000100266
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pacsin2ENSDARG00000078014Danio rerio
 PACSIN2ENSGALG00000014159Gallus gallus
 Q9WVE8ENSMUSG00000016664Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9BY11 / PACSIN1 / protein kinase C and casein kinase substrate in neurons 1ENSG0000012450762
Q9UKS6 / PACSIN3 / protein kinase C and casein kinase substrate in neurons 3ENSG0000016591249


Protein motifs (from Interpro)
Interpro ID Name
 IPR001060  FCH domain
 IPR001452  SH3 domain
 IPR027267  AH/BAR domain superfamily
 IPR028521  Protein kinase C and casein kinase substrate in neurons protein 2
 IPR031160  F-BAR domain
 IPR035743  PACSIN1/PACSIN2, SH3 domain
 IPR036028  SH3-like domain superfamily
 IPR037453  PACSIN2, F-BAR domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0030036 actin cytoskeleton organization TAS
 biological_processGO:0030100 regulation of endocytosis IBA
 biological_processGO:0036010 protein localization to endosome IMP
 biological_processGO:0045806 negative regulation of endocytosis IEA
 biological_processGO:0048858 cell projection morphogenesis ISS
 biological_processGO:0061024 membrane organization TAS
 biological_processGO:0070836 caveola assembly IMP
 biological_processGO:0072584 caveolin-mediated endocytosis IMP
 biological_processGO:0097320 plasma membrane tubulation ISS
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005901 caveola IEA
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016607 nuclear speck IDA
 cellular_componentGO:0019898 extrinsic component of membrane ISS
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0055038 recycling endosome membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005215 transporter activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008092 cytoskeletal protein binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0045296 cadherin binding IDA
 molecular_functionGO:0070300 phosphatidic acid binding IDA


Pathways (from Reactome)
Pathway description
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100266 Q9UNF0 / PACSIN2 / protein kinase C and casein kinase substrate in neurons 2  / complex






 

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