ENSG00000124507


Homo sapiens

Features
Gene ID: ENSG00000124507
  
Biological name :PACSIN1
  
Synonyms : PACSIN1 / protein kinase C and casein kinase substrate in neurons 1 / Q9BY11
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: p21.31
Gene start: 34466061
Gene end: 34535231
  
Corresponding Affymetrix probe sets: 224360_s_at (Human Genome U133 Plus 2.0 Array)   227053_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000244458
Ensembl peptide - ENSP00000363155
Ensembl peptide - ENSP00000439639
Ensembl peptide - ENSP00000484060
NCBI entrez gene - 29993     See in Manteia.
OMIM - 606512
RefSeq - XM_011514541
RefSeq - NM_001199583
RefSeq - NM_020804
RefSeq Peptide - NP_001186512
RefSeq Peptide - NP_065855
swissprot - Q5TZC3
swissprot - Q9BY11
swissprot - F6U236
Ensembl - ENSG00000124507
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pacsin1aENSDARG00000032865Danio rerio
 Q4V920ENSDARG00000042128Danio rerio
 PACSIN1ENSGALG00000002802Gallus gallus
 Q61644ENSMUSG00000040276Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9UNF0 / PACSIN2 / protein kinase C and casein kinase substrate in neurons 2ENSG0000010026668
Q9UKS6 / PACSIN3 / protein kinase C and casein kinase substrate in neurons 3ENSG0000016591249


Protein motifs (from Interpro)
Interpro ID Name
 IPR001060  FCH domain
 IPR001452  SH3 domain
 IPR027267  AH/BAR domain superfamily
 IPR028518  Protein kinase C and casein kinase substrate in neurons protein 1
 IPR031160  F-BAR domain
 IPR035743  PACSIN1/PACSIN2, SH3 domain
 IPR036028  SH3-like domain superfamily
 IPR037454  PACSIN1, F-BAR


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0007015 actin filament organization IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030100 regulation of endocytosis IBA
 biological_processGO:0045806 negative regulation of endocytosis IEA
 biological_processGO:0048488 synaptic vesicle endocytosis ISS
 biological_processGO:0048666 neuron development IEA
 biological_processGO:0048812 neuron projection morphogenesis IBA
 biological_processGO:0072657 protein localization to membrane ISS
 biological_processGO:0072659 protein localization to plasma membrane ISS
 biological_processGO:0097320 plasma membrane tubulation IDA
 biological_processGO:1900006 positive regulation of dendrite development ISS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005768 endosome IBA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030137 COPI-coated vesicle IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0032587 ruffle membrane ISS
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043209 myelin sheath IEA
 cellular_componentGO:0043679 axon terminus ISS
 cellular_componentGO:0045202 synapse ISS
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005543 phospholipid binding IDA
 molecular_functionGO:0008092 cytoskeletal protein binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000124507 Q9BY11 / PACSIN1 / protein kinase C and casein kinase substrate in neurons 1  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr