ENSDARG00000042128


Danio rerio

Features
Gene ID: ENSDARG00000042128
  
Biological name :pacsin1b
  
Synonyms : pacsin1b / protein kinase C and casein kinase substrate in neurons 1b / Q4V920
  
Possible biological names infered from orthology : PACSIN1 / protein kinase C and casein kinase substrate in neurons 1 / Protein kinase C and casein kinase substrate in neurons protein 1 / Q61644 / Q9BY11
  
Species: Danio rerio
  
Chr. number: 6
Strand: 1
Band:
Gene start: 54187643
Gene end: 54271549
  
Corresponding Affymetrix probe sets: Dr.7660.1.A1_at (Zebrafish Array)   NM_001033728_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000136926
Ensembl peptide - ENSDARP00000056829
Ensembl peptide - ENSDARP00000107643
Ensembl peptide - ENSDARP00000123765
NCBI entrez gene - 619246     See in Manteia.
RefSeq - NM_001033728
RefSeq - XM_005166140
RefSeq Peptide - NP_001028900
swissprot - F8W574
swissprot - B2GTA5
swissprot - Q4V920
ZFIN ID - ZDB-GENE-050913-35
Ensembl - ENSDARG00000042128
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PACSIN1ENSGALG00000002802Gallus gallus
 Q9BY11ENSG00000124507Homo sapiens
 Q61644ENSMUSG00000040276Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
pacsin1a / protein kinase C and casein kinase substrate in neurons 1a / Q61644* / Q9BY11* / PACSIN1* / protein kinase C and casein kinase substrate in neurons 1* / Protein kinase C and case...ENSDARG0000003286574
pacsin2 / protein kinase C and casein kinase substrate in neurons 2 / Q9UNF0* / Q9WVE8*ENSDARG0000007801461
pacsin3 / protein kinase C and casein kinase substrate in neurons 3 / Q99JB8* / Q9UKS6* / Protein kinase C and casein kinase II substrate protein 3 *ENSDARG0000009933942
si:ch211-51c14.1ENSDARG0000005464541
zgc:91999ENSDARG0000010500126


Protein motifs (from Interpro)
Interpro ID Name
 IPR001060  FCH domain
 IPR001452  SH3 domain
 IPR027267  AH/BAR domain superfamily
 IPR028518  Protein kinase C and casein kinase substrate in neurons protein 1
 IPR031160  F-BAR domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0007015 actin filament organization IEA
 biological_processGO:0030100 regulation of endocytosis IBA
 biological_processGO:0048666 neuron development IEA
 biological_processGO:0048812 neuron projection morphogenesis IBA
 biological_processGO:0060088 auditory receptor cell stereocilium organization IMP
 biological_processGO:0097320 plasma membrane tubulation IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IBA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0008289 lipid binding IEA


Pathways (from Reactome)
Pathway description
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain edematous , abnormal
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 ZFA:0000092 axis axis decreased length , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000114 heart heart edematous , abnormal
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 ZFA:0000940 posterior lateral line neuromast posterior lateral line neuromast has fewer parts of type neuromast kinocilium, abnormal
posterior lateral line neuromast stereocilium decreased length , abnormal
posterior lateral line neuromast kinocilium decreased length , abnormal
posterior lateral line neuromast decreased amount , abnormal
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 ZFA:0001094 whole organism whole organism increased curvature , abnormal
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 ZFA:0001114 head head decreased size , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000042128 Q4V920 / pacsin1b / protein kinase C and casein kinase substrate in neurons 1b / Q61644* / Q9BY11* / PACSIN1* / protein kinase C and casein kinase substrate in neurons 1* / Protein kinase C...  / complex
 ENSDARG00000032865 pacsin1a / protein kinase C and casein kinase substrate in neurons 1a / Q61644* / Q9BY11* / PACSIN1* / protein kinase C and casein kinase substrate in neurons 1* / Protein kinase C and case...  / complex






 

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