ENSMUSG00000017264


Mus musculus

Features
Gene ID: ENSMUSG00000017264
  
Biological name :Exosc10
  
Synonyms : Exosc10 / Mus musculus exosome component 10 (Exosc10), transcript variant 5, mRNA. / P56960
  
Possible biological names infered from orthology : exosome component 10 / Q01780
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: E2
Gene start: 148558429
Gene end: 148582401
  
Corresponding Affymetrix probe sets: 10510365 (MoGene1.0st)   1423587_a_at (Mouse Genome 430 2.0 Array)   1431832_x_at (Mouse Genome 430 2.0 Array)   1437294_at (Mouse Genome 430 2.0 Array)   1454021_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000017408
Ensembl peptide - ENSMUSP00000075401
Ensembl peptide - ENSMUSP00000095388
Ensembl peptide - ENSMUSP00000133336
NCBI entrez gene - 50912     See in Manteia.
MGI - MGI:1355322
RefSeq - XM_017320312
RefSeq - NM_001355490
RefSeq - NM_016699
RefSeq - XM_006539023
RefSeq - XM_006539024
RefSeq - XM_011250300
RefSeq - XM_017320311
RefSeq Peptide - NP_001342419
RefSeq Peptide - NP_057908
swissprot - G3UWL4
swissprot - Q8K366
swissprot - F6VYQ6
swissprot - P56960
Ensembl - ENSMUSG00000017264
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 exosc10ENSDARG00000037708Danio rerio
 EXOSC10ENSGALG00000003086Gallus gallus
 Q01780ENSG00000171824Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002121  HRDC domain
 IPR002562  3"-5" exonuclease domain
 IPR010997  HRDC-like superfamily
 IPR012337  Ribonuclease H-like superfamily
 IPR012588  Exosome-associated factor Rrp6, N-terminal
 IPR036397  Ribonuclease H superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
 biological_processGO:0000460 maturation of 5.8S rRNA IEA
 biological_processGO:0000956 nuclear-transcribed mRNA catabolic process IEA
 biological_processGO:0006139 nucleobase-containing compound metabolic process IEA
 biological_processGO:0006364 rRNA processing IEA
 biological_processGO:0006396 RNA processing IEA
 biological_processGO:0009048 dosage compensation by inactivation of X chromosome IMP
 biological_processGO:0032211 negative regulation of telomere maintenance via telomerase IEA
 biological_processGO:0044237 cellular metabolic process IEA
 biological_processGO:0071028 nuclear mRNA surveillance IEA
 biological_processGO:0071034 CUT catabolic process IEA
 biological_processGO:0071035 nuclear polyadenylation-dependent rRNA catabolic process IEA
 biological_processGO:0071044 histone mRNA catabolic process IEA
 biological_processGO:0071048 nuclear retention of unspliced pre-mRNA at the site of transcription IEA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 biological_processGO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic IEA
 biological_processGO:1904872 regulation of telomerase RNA localization to Cajal body IEA
 cellular_componentGO:0000176 nuclear exosome (RNase complex) IEA
 cellular_componentGO:0000178 exosome (RNase complex) ISS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005730 nucleolus ISS
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0035327 transcriptionally active chromatin IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000175 3"-5"-exoribonuclease activity IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004527 exonuclease activity IEA
 molecular_functionGO:0004532 exoribonuclease activity IEA
 molecular_functionGO:0008408 3"-5" exonuclease activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Major pathway of rRNA processing in the nucleolus and cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dll4tm3.1Vlcg/Dll4+,Gt(ROSA)26Sortm3.1(cre/ERT2)Vlcg/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031843 Q9D1Q1 / Mphosph6 / Mus musculus M phase phosphoprotein 6 (Mphosph6), transcript variant 3, mRNA. / Q99547* / M-phase phosphoprotein 6*  / complex
 ENSMUSG00000000581 C1d / O35473 / Mus musculus C1D nuclear receptor co-repressor (C1d), transcript variant 2, mRNA. / Q13901* / C1D nuclear receptor corepressor*  / complex
 ENSMUSG00000016018 Q9CZU3 / Skiv2l2 / Superkiller viralicidic activity 2-like 2 / MTREX* / P42285* / Mtr4 exosome RNA helicase*  / complex






 

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