ENSG00000171824


Homo sapiens

Features
Gene ID: ENSG00000171824
  
Biological name :EXOSC10
  
Synonyms : EXOSC10 / exosome component 10 / Q01780
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p36.22
Gene start: 11066618
Gene end: 11099881
  
Corresponding Affymetrix probe sets: 1559031_at (Human Genome U133 Plus 2.0 Array)   207541_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000307307
Ensembl peptide - ENSP00000366135
Ensembl peptide - ENSP00000465008
NCBI entrez gene - 5394     See in Manteia.
OMIM - 605960
RefSeq - XM_017001497
RefSeq - NM_001001998
RefSeq - NM_002685
RefSeq - XM_005263475
RefSeq - XM_017001494
RefSeq - XM_017001495
RefSeq - XM_017001496
RefSeq Peptide - NP_001001998
RefSeq Peptide - NP_002676
swissprot - Q01780
swissprot - K7EJ37
Ensembl - ENSG00000171824
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 exosc10ENSDARG00000037708Danio rerio
 EXOSC10ENSGALG00000003086Gallus gallus
 P56960ENSMUSG00000017264Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002121  HRDC domain
 IPR002562  3"-5" exonuclease domain
 IPR010997  HRDC-like superfamily
 IPR012337  Ribonuclease H-like superfamily
 IPR012588  Exosome-associated factor Rrp6, N-terminal
 IPR036397  Ribonuclease H superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
 biological_processGO:0000460 maturation of 5.8S rRNA IMP
 biological_processGO:0000956 nuclear-transcribed mRNA catabolic process IMP
 biological_processGO:0006139 nucleobase-containing compound metabolic process IEA
 biological_processGO:0006364 rRNA processing TAS
 biological_processGO:0006396 RNA processing IEA
 biological_processGO:0009048 dosage compensation by inactivation of X chromosome IEA
 biological_processGO:0032211 negative regulation of telomere maintenance via telomerase IMP
 biological_processGO:0044237 cellular metabolic process IEA
 biological_processGO:0071028 nuclear mRNA surveillance IMP
 biological_processGO:0071034 CUT catabolic process IMP
 biological_processGO:0071035 nuclear polyadenylation-dependent rRNA catabolic process IMP
 biological_processGO:0071044 histone mRNA catabolic process IMP
 biological_processGO:0071048 nuclear retention of unspliced pre-mRNA at the site of transcription IMP
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 biological_processGO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic IEA
 biological_processGO:1904872 regulation of telomerase RNA localization to Cajal body IMP
 cellular_componentGO:0000176 nuclear exosome (RNase complex) IEA
 cellular_componentGO:0000178 exosome (RNase complex) IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0035327 transcriptionally active chromatin IMP
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000175 3"-5"-exoribonuclease activity IMP
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004527 exonuclease activity IEA
 molecular_functionGO:0004532 exoribonuclease activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008408 3"-5" exonuclease activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0070034 telomerase RNA binding IC


Pathways (from Reactome)
Pathway description
Major pathway of rRNA processing in the nucleolus and cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000039123 MTREX / P42285 / Mtr4 exosome RNA helicase  / complex
 ENSG00000197223 C1D / Q13901 / C1D nuclear receptor corepressor  / complex
 ENSG00000135698 Q99547 / MPHOSPH6 / M-phase phosphoprotein 6  / complex






 

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