ENSG00000039123


Homo sapiens

Features
Gene ID: ENSG00000039123
  
Biological name :MTREX
  
Synonyms : Mtr4 exosome RNA helicase / MTREX / P42285
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q11.2
Gene start: 55307760
Gene end: 55425581
  
Corresponding Affymetrix probe sets: 1562142_at (Human Genome U133 Plus 2.0 Array)   212896_at (Human Genome U133 Plus 2.0 Array)   227447_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000425042
Ensembl peptide - ENSP00000426641
Ensembl peptide - ENSP00000230640
Ensembl peptide - ENSP00000422125
NCBI entrez gene - 23517     See in Manteia.
RefSeq - NM_015360
RefSeq Peptide - NP_056175
swissprot - D6REC7
swissprot - H0Y8U3
swissprot - H0YAC4
swissprot - P42285
Ensembl - ENSG00000039123
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mtrexENSDARG00000013457Danio rerio
 SKIV2L2ENSGALG00000014709Gallus gallus
 Q9CZU3ENSMUSG00000016018Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q15477 / SKIV2L / Ski2 like RNA helicaseENSG0000020435136
DDX60 / Q8IY21 / DExD/H-box helicase 60ENSG0000013762819
DDX60L / Q5H9U9 / DExD/H-box 60 likeENSG0000018138118


Protein motifs (from Interpro)
Interpro ID Name
 IPR001650  Helicase, C-terminal
 IPR011545  DEAD/DEAH box helicase domain
 IPR012961  ATP-dependent RNA helicase Ski2, C-terminal
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR016438  ATP-dependent RNA helicase Ski2-like
 IPR025696  rRNA-processing arch domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000398 mRNA splicing, via spliceosome TAS
 biological_processGO:0000460 maturation of 5.8S rRNA IMP
 biological_processGO:0006364 rRNA processing TAS
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0006401 RNA catabolic process IBA
 biological_processGO:0008380 RNA splicing IEA
 cellular_componentGO:0000178 exosome (RNase complex) IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005681 spliceosomal complex IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0071013 catalytic step 2 spliceosome IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0003724 RNA helicase activity IEA
 molecular_functionGO:0004004 ATP-dependent RNA helicase activity IBA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Major pathway of rRNA processing in the nucleolus and cytosol
mRNA Splicing - Major Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000135698 Q99547 / MPHOSPH6 / M-phase phosphoprotein 6  / complex
 ENSG00000171824 Q01780 / EXOSC10 / exosome component 10  / complex
 ENSG00000197223 C1D / Q13901 / C1D nuclear receptor corepressor  / complex






 

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