ENSMUSG00000019179


Mus musculus

Features
Gene ID: ENSMUSG00000019179
  
Biological name :Mdh2
  
Synonyms : Malate dehydrogenase, mitochondrial / Mdh2 / P08249
  
Possible biological names infered from orthology : malate dehydrogenase 2 / P40926
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: G2
Gene start: 135778480
Gene end: 135790398
  
Corresponding Affymetrix probe sets: 10526381 (MoGene1.0st)   1416478_a_at (Mouse Genome 430 2.0 Array)   1433984_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000136225
Ensembl peptide - ENSMUSP00000143748
Ensembl peptide - ENSMUSP00000142993
Ensembl peptide - ENSMUSP00000019323
NCBI entrez gene - 17448     See in Manteia.
MGI - MGI:97050
RefSeq - NM_008617
RefSeq Peptide - NP_032643
swissprot - A0A0G2JF23
swissprot - J3QMC8
swissprot - A0A0G2JGY4
swissprot - P08249
Ensembl - ENSMUSG00000019179
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mdh2ENSDARG00000043371Danio rerio
 MDH2ENSGALG00000001949Gallus gallus
 MDH2ENSG00000146701Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001236  Lactate/malate dehydrogenase, N-terminal
 IPR001252  Malate dehydrogenase, active site
 IPR001557  L-lactate/malate dehydrogenase
 IPR010097  Malate dehydrogenase, type 1
 IPR015955  Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
 IPR022383  Lactate/malate dehydrogenase, C-terminal
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0006099 tricarboxylic acid cycle IEA
 biological_processGO:0006107 oxaloacetate metabolic process IEA
 biological_processGO:0006108 malate metabolic process IEA
 biological_processGO:0006475 internal protein amino acid acetylation IEA
 biological_processGO:0006734 NADH metabolic process IEA
 biological_processGO:0009060 aerobic respiration IEA
 biological_processGO:0019752 carboxylic acid metabolic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005743 mitochondrial inner membrane IDA
 cellular_componentGO:0005759 mitochondrial matrix ISS
 cellular_componentGO:0016020 membrane IMP
 cellular_componentGO:0043209 myelin sheath IDA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016615 malate dehydrogenase activity IEA
 molecular_functionGO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
 molecular_functionGO:0030060 L-malate dehydrogenase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity ISS
 molecular_functionGO:0043621 protein self-association IEA
 molecular_functionGO:0046554 malate dehydrogenase (NADP+) activity IEA


Pathways (from Reactome)
Pathway description
Gluconeogenesis
Citric acid cycle (TCA cycle)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000019179 Mdh2 / P08249 / Malate dehydrogenase, mitochondrial / P40926* / malate dehydrogenase 2*  / complex






 

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