ENSMUSG00000019194


Mus musculus

Features
Gene ID: ENSMUSG00000019194
  
Biological name :Scn1b
  
Synonyms : P97952 / Scn1b / Sodium channel subunit beta-1
  
Possible biological names infered from orthology : Q07699 / sodium voltage-gated channel beta subunit 1
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: B1
Gene start: 31116524
Gene end: 31127003
  
Corresponding Affymetrix probe sets: 10562251 (MoGene1.0st)   1418738_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000096148
Ensembl peptide - ENSMUSP00000148295
NCBI entrez gene - 20266     See in Manteia.
MGI - MGI:98247
RefSeq - XM_017322064
RefSeq - NM_011322
RefSeq Peptide - NP_035452
swissprot - P97952
Ensembl - ENSMUSG00000019194
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 scn1baENSDARG00000060222Danio rerio
 scn1bbENSDARG00000105003Danio rerio
 si:ch211-225p5.8ENSDARG00000070170Danio rerio
 SCN1BENSG00000105711Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Scn3b / Q8BHK2 / sodium channel, voltage-gated, type III, beta / Q9NY72* / sodium voltage-gated channel beta subunit 3*ENSMUSG0000004928144


Protein motifs (from Interpro)
Interpro ID Name
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR027098  Sodium channel subunit beta-1/beta-3
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002028 regulation of sodium ion transport IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0007411 axon guidance IMP
 biological_processGO:0010765 positive regulation of sodium ion transport IEA
 biological_processGO:0010976 positive regulation of neuron projection development IGI
 biological_processGO:0019227 neuronal action potential propagation IMP
 biological_processGO:0021966 corticospinal neuron axon guidance IMP
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0035725 sodium ion transmembrane transport IMP
 biological_processGO:0040011 locomotion IMP
 biological_processGO:0046684 response to pyrethroid IEA
 biological_processGO:0051899 membrane depolarization IEA
 biological_processGO:0060048 cardiac muscle contraction IEA
 biological_processGO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization IMP
 biological_processGO:0060371 regulation of atrial cardiac muscle cell membrane depolarization IEA
 biological_processGO:0061337 cardiac conduction IMP
 biological_processGO:0086002 cardiac muscle cell action potential involved in contraction IEA
 biological_processGO:0086012 membrane depolarization during cardiac muscle cell action potential IMP
 biological_processGO:0086047 membrane depolarization during Purkinje myocyte cell action potential IEA
 biological_processGO:0086091 regulation of heart rate by cardiac conduction IEA
 biological_processGO:2000649 regulation of sodium ion transmembrane transporter activity IEA
 cellular_componentGO:0001518 voltage-gated sodium channel complex ISO
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0014704 intercalated disc IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030315 T-tubule IDA
 cellular_componentGO:0033268 node of Ranvier IDA
 cellular_componentGO:0034706 sodium channel complex IPI
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005248 voltage-gated sodium channel activity IEA
 molecular_functionGO:0005272 sodium channel activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017080 sodium channel regulator activity ISO
 molecular_functionGO:0019871 sodium channel inhibitor activity IMP
 molecular_functionGO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential IMP
 molecular_functionGO:0086062 voltage-gated sodium channel activity involved in Purkinje myocyte action potential IEA


Pathways (from Reactome)
Pathway description
Phase 0 - rapid depolarisation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Scn1btm1.1Bion/Scn1btm1.1Bion
Genetic Background: Not Specified

 MP:0001330 abnormal optic nerve morphology "malformation, misprojection or atrophy in the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn
Genetic Background: involves: C57BL/6

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn
Genetic Background: involves: C57BL/6

Allelic Composition: Scn1btm2.1Isom/Scn1btm2.1Isom
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn
Genetic Background: involves: C57BL/6

Allelic Composition: Scn1btm2.1Isom/Scn1btm2.1Isom
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Scn1btm1.1Bion/Scn1btm1.1Bion
Genetic Background: Not Specified

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn
Genetic Background: involves: C57BL/6

Allelic Composition: Scn1btm2.1Isom/Scn1btm2.1Isom
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Scn1btm1.1Bion/Scn1btm1.1Bion
Genetic Background: Not Specified

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Scn1btm1.1Bion/Scn1btm1.1Bion
Genetic Background: Not Specified

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nos2tm1Lau/Nos2tm1Lau,Tg(APPSWE)2576Kha/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Scn1btm1.1Bion/Scn1btm1.1Bion
Genetic Background: Not Specified

 MP:0003632 abnormal nervous system morphology 
Show

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn
Genetic Background: involves: C57BL/6

 MP:0003997 tonic-clonic seizures "increased number or decreased threshold for the induction of a seizure characterized by initial rigidity followed by rhythmic jerking movements" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Scn1btm1.1Bion/Scn1btm1.1Bion
Genetic Background: Not Specified

 MP:0004994 abnormal brain wave pattern "any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG); the pattern is often measured to diagnose neurological conditions such as seizure disorders (epilepsy)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Scn1btm1.1Bion/Scn1btm1.1Bion
Genetic Background: Not Specified

 MP:0005402 abnormal action potential "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn
Genetic Background: involves: C57BL/6

Allelic Composition: Scn1btm1.1Bion/Scn1b+
Genetic Background: Not Specified

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn
Genetic Background: involves: C57BL/6

 MP:0009358 environmentally induced seizures "relatively mild but sudden stimulation due to changes in ambient habitat including lighting, sounds, touching, and/ or moving cage" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Scn1btm1.1Bion/Scn1btm1.1Bion
Genetic Background: Not Specified

Allelic Composition: Scn1btm1.1Bion/Scn1b+
Genetic Background: Not Specified

 MP:0011083 complete lethality at weaning "premature death at weaning age of all organisms of a given genotype in a population, often due to the inability to make the transition to solid food" [MGI:csmith]
Show

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn
Genetic Background: involves: C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Scn1btm2.1Isom/Scn1btm2.1Isom
Genetic Background: involves: 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000032511 Scn5a / Q9JJV9 / Sodium channel protein type 5 subunit alpha / Q14524* / sodium voltage-gated channel alpha subunit 5*  / complex






 

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