ENSMUSG00000032511


Mus musculus

Features
Gene ID: ENSMUSG00000032511
  
Biological name :Scn5a
  
Synonyms : Q9JJV9 / Scn5a / Sodium channel protein type 5 subunit alpha
  
Possible biological names infered from orthology : Q14524 / sodium voltage-gated channel alpha subunit 5
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: F3
Gene start: 119483408
Gene end: 119579016
  
Corresponding Affymetrix probe sets: 10597656 (MoGene1.0st)   1422194_at (Mouse Genome 430 2.0 Array)   1458813_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118250
Ensembl peptide - ENSMUSP00000066228
Ensembl peptide - ENSMUSP00000112838
Ensembl peptide - ENSMUSP00000113272
NCBI entrez gene - 20271     See in Manteia.
MGI - MGI:98251
RefSeq - XM_006511997
RefSeq - NM_001253860
RefSeq - NM_021544
RefSeq - XM_006511993
RefSeq - XM_006511995
RefSeq - XM_006511996
RefSeq Peptide - NP_067519
RefSeq Peptide - NP_001240789
swissprot - K3W4N7
swissprot - D3YXW2
swissprot - Q9JJV9
swissprot - A0A0R4J1M7
Ensembl - ENSMUSG00000032511
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 scn12aaENSDARG00000090724Danio rerio
 scn12abENSDARG00000102312Danio rerio
 SCN5AENSGALG00000006112Gallus gallus
 SCN5AENSG00000183873Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Scn2a / sodium channel, voltage-gated, type II, alpha / Q99250* / sodium voltage-gated channel alpha subunit 2*ENSMUSG0000007531864
Scn1a / A2APX8 / Sodium channel protein type 1 subunit alpha / P35498* / sodium voltage-gated channel alpha subunit 1*ENSMUSG0000006432963
Scn3a / sodium channel, voltage-gated, type III, alpha / Q9NY46* / sodium voltage-gated channel alpha subunit 3*ENSMUSG0000005718262
Scn9a / Q62205 / Sodium channel protein type 9 subunit alpha / Q15858* / sodium voltage-gated channel alpha subunit 9*ENSMUSG0000007531662
Scn8a / sodium channel, voltage-gated, type VIII, alpha / Q9UQD0* / sodium voltage-gated channel alpha subunit 8*ENSMUSG0000002303362
Q6QIY3 / Scn10a / sodium channel, voltage-gated, type X, alpha / Q9Y5Y9* / sodium voltage-gated channel alpha subunit 10*ENSMUSG0000003453360
Scn4a / sodium channel, voltage-gated, type IV, alpha / P35499* / sodium voltage-gated channel alpha subunit 4*ENSMUSG0000000102759
Q9R053 / Scn11a / Sodium channel protein type 11 subunit alpha / Q9UI33* / sodium voltage-gated channel alpha subunit 11*ENSMUSG0000003411547
Scn7a / sodium voltage-gated channel alpha subunit 7 / Q01118*ENSMUSG0000003481037
Cacna1h / voltage-dependent T-type calcium channel subunit alpha-1H isoform 2 / O95180* / calcium voltage-gated channel subunit alpha1 H*ENSMUSG0000002411224
Cacna1g / calcium channel, voltage-dependent, T type, alpha 1G subunit / O43497* / calcium voltage-gated channel subunit alpha1 G*ENSMUSG0000002086623
Cacna1i / calcium channel, voltage-dependent, alpha 1I subunit / Q9P0X4* / calcium voltage-gated channel subunit alpha1 I*ENSMUSG0000002241622


Protein motifs (from Interpro)
Interpro ID Name
 IPR001696  Voltage gated sodium channel, alpha subunit
 IPR005821  Ion transport domain
 IPR008053  Voltage gated sodium channel, alpha-5 subunit
 IPR010526  Sodium ion transport-associated
 IPR024583  Voltage-gated Na+ ion channel, cytoplasmic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002027 regulation of heart rate ISO
 biological_processGO:0003231 cardiac ventricle development IMP
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0010765 positive regulation of sodium ion transport ISO
 biological_processGO:0014070 response to organic cyclic compound IMP
 biological_processGO:0019228 neuronal action potential IBA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0035725 sodium ion transmembrane transport IEA
 biological_processGO:0051899 membrane depolarization ISO
 biological_processGO:0055074 calcium ion homeostasis IMP
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0060048 cardiac muscle contraction ISO
 biological_processGO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization ISO
 biological_processGO:0060371 regulation of atrial cardiac muscle cell membrane depolarization ISO
 biological_processGO:0060372 regulation of atrial cardiac muscle cell membrane repolarization ISO
 biological_processGO:0060373 regulation of ventricular cardiac muscle cell membrane depolarization ISO
 biological_processGO:0071277 cellular response to calcium ion ISO
 biological_processGO:0086002 cardiac muscle cell action potential involved in contraction ISO
 biological_processGO:0086004 regulation of cardiac muscle cell contraction ISO
 biological_processGO:0086005 ventricular cardiac muscle cell action potential ISO
 biological_processGO:0086010 membrane depolarization during action potential ISO
 biological_processGO:0086012 membrane depolarization during cardiac muscle cell action potential ISO
 biological_processGO:0086014 atrial cardiac muscle cell action potential ISO
 biological_processGO:0086015 SA node cell action potential ISO
 biological_processGO:0086016 AV node cell action potential ISO
 biological_processGO:0086043 bundle of His cell action potential ISO
 biological_processGO:0086045 membrane depolarization during AV node cell action potential ISO
 biological_processGO:0086046 membrane depolarization during SA node cell action potential ISO
 biological_processGO:0086047 membrane depolarization during Purkinje myocyte cell action potential ISO
 biological_processGO:0086048 membrane depolarization during bundle of His cell action potential ISO
 biological_processGO:0086067 AV node cell to bundle of His cell communication ISO
 biological_processGO:0086091 regulation of heart rate by cardiac conduction ISO
 biological_processGO:0098912 membrane depolarization during atrial cardiac muscle cell action potential ISO
 biological_processGO:1902305 regulation of sodium ion transmembrane transport ISO
 cellular_componentGO:0001518 voltage-gated sodium channel complex IEA
 cellular_componentGO:0005622 intracellular ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005901 caveola ISO
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0014704 intercalated disc ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016328 lateral plasma membrane IDA
 cellular_componentGO:0030018 Z disc ISO
 cellular_componentGO:0030315 T-tubule ISO
 cellular_componentGO:0034706 sodium channel complex IPI
 cellular_componentGO:0042383 sarcolemma ISO
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005248 voltage-gated sodium channel activity IEA
 molecular_functionGO:0005272 sodium channel activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding ISO
 molecular_functionGO:0017134 fibroblast growth factor binding ISO
 molecular_functionGO:0019899 enzyme binding ISO
 molecular_functionGO:0019901 protein kinase binding ISO
 molecular_functionGO:0019904 protein domain specific binding ISO
 molecular_functionGO:0030506 ankyrin binding ISO
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISO
 molecular_functionGO:0044325 ion channel binding ISO
 molecular_functionGO:0050998 nitric-oxide synthase binding ISO
 molecular_functionGO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential ISO
 molecular_functionGO:0086060 voltage-gated sodium channel activity involved in AV node cell action potential ISO
 molecular_functionGO:0086061 voltage-gated sodium channel activity involved in bundle of His cell action potential ISO
 molecular_functionGO:0086062 voltage-gated sodium channel activity involved in Purkinje myocyte action potential ISO
 molecular_functionGO:0086063 voltage-gated sodium channel activity involved in SA node cell action potential ISO
 molecular_functionGO:0097110 scaffold protein binding IPI


Pathways (from Reactome)
Pathway description
Phase 0 - rapid depolarisation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cst3tm1Karl/Cst3tm1Karl
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001629 abnormal heart rate "greater than or fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cst3tm1Karl/Cst3tm1Karl
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001636 irregular heartbeat "uneven timing of heart contraction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33038]
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Allelic Composition: Gja1tm1Kdr/Gja1tm1Kdr,Tg(CMV-Gja1)BClo/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * SJL/J * SWR/J

Allelic Composition: Scn5atm1Clhh/Scn5atm1Clhh
Genetic Background: involves: 129 * 129S/SvEv * C57BL/6J

Allelic Composition: Scn5atm1Clhh/Scn5a+
Genetic Background: involves: 129 * 129S/SvEv * C57BL/6J

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cst3tm1Karl/Cst3tm1Karl
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Scn5atm1Clhh/Scn5atm1Clhh
Genetic Background: involves: 129 * 129S/SvEv * C57BL/6J

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Scn5atm1Clhh/Scn5atm1Clhh
Genetic Background: involves: 129 * 129S/SvEv * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gja1tm1Kdr/Gja1tm1Kdr,Tg(CMV-Gja1)BClo/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * SJL/J * SWR/J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmpertm2Ysas/Bmpertm2Ysas
Genetic Background: involves: C57BL/6 * CBA

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Capn1tm1.1Arte/Capn1tm1.1Arte,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6

Allelic Composition: Scn5atm1(SCN5A)Rdn/Scn5atm3(SCN5A*)Rdn
Genetic Background: involves: 129S6/SvEvTac

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Scn5atm3(SCN5A*)Rdn/Scn5atm3(SCN5A*)Rdn
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Scn5atm1(SCN5A)Rdn/Scn5atm3(SCN5A*)Rdn
Genetic Background: involves: 129S6/SvEvTac

 MP:0002972 abnormal cardiac muscle contractility "altered ability of the heart muscle to shorten or to develop increased tension, often measured by dP/dT max" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cst3tm1Karl/Cst3tm1Karl
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0003137 abnormal impulse conducting system conduction "anomaly in the impulse-conducting system composed of modified cardiac muscle and having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart" [hdene:Howard Dene , Mouse Genome Informatics Curator, J:92050, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cst3tm1Karl/Cst3tm1Karl
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Scn5atm1Pec/Scn5a+
Genetic Background: involves: Swiss

Allelic Composition: Scn5atm1Agrc/Scn5a+
Genetic Background: involves: 129/Sv

Allelic Composition: Scn5atm1Clhh/Scn5a+
Genetic Background: involves: 129 * 129S/SvEv * C57BL/6J

Allelic Composition: Scn5atm1Care/Scn5a+
Genetic Background: FVB.129P2-Scn5atm1Care

Allelic Composition: Scn5atm1Clhh/Scn5a+
Genetic Background: involves: 129/SvEv

Allelic Composition: Scn5atm2.1Care/Scn5atm2.1Care
Genetic Background: B6J.129P2(Cg)-Scn5atm2.1Care

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Scn5atm1Agrc/Scn5a+
Genetic Background: involves: 129/Sv

 MP:0003233 prolonged QT interval "increase in the length of time required for ventricular depolarization and repolarization to occur, usually as a result of increased repolarization time" [J:93197, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Scn5atm1Pec/Scn5a+
Genetic Background: involves: Swiss

Allelic Composition: Scn5atm1Agrc/Scn5a+
Genetic Background: involves: 129/Sv

Allelic Composition: Scn5atm1Care/Scn5a+
Genetic Background: FVB.129P2-Scn5atm1Care

Allelic Composition: Scn5atm1Clhh/Scn5a+
Genetic Background: involves: 129/SvEv

 MP:0003896 prolonged PQ interval "increase in the length of time between the beginning of atrial depolarisation and the beginning of ventricular depolarisation" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cst3tm1Karl/Cst3tm1Karl
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Scn5atm1Agrc/Scn5a+
Genetic Background: involves: 129/Sv

Allelic Composition: Scn5atm3(SCN5A*)Rdn/Scn5atm3(SCN5A*)Rdn
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Scn5atm1Clhh/Scn5a+
Genetic Background: involves: 129/SvEv

Allelic Composition: Scn5atm2.1Care/Scn5atm2.1Care
Genetic Background: B6J.129P2(Cg)-Scn5atm2.1Care

 MP:0003900 shortened QT interval "decrease in the length of time required for ventricular depolarization and repolarization to occur, usually as a result of increased repolarization time" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Frem2b2b1562Clo/Frem2b2b1562Clo
Genetic Background: C57BL/6J-Frem2b2b1562Clo

 MP:0004067 abnormal ventricular trabeculae morphology "aberrant structure of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cst3tm1Karl/Cst3tm1Karl
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0004071 prolonged P wave "increase in the length of time of the P wave electrical impulses" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cst3tm1Karl/Cst3tm1Karl
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Scn5atm1Agrc/Scn5a+
Genetic Background: involves: 129/Sv

Allelic Composition: Scn5atm3(SCN5A*)Rdn/Scn5atm3(SCN5A*)Rdn
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Scn5atm1(SCN5A)Rdn/Scn5atm3(SCN5A*)Rdn
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Scn5atm2.1Care/Scn5atm2.1Care
Genetic Background: B6J.129P2(Cg)-Scn5atm2.1Care

 MP:0004116 abnormal atrioventricular bundle conduction "anomaly in the transfer of cardiac electrical impulses through the specialized cardiac muscle fibers that originates in the atrioventricular node and extends into the ventricle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Scn5atm2.1Care/Scn5atm2.1Care
Genetic Background: B6J.129P2(Cg)-Scn5atm2.1Care

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cst3tm1Karl/Cst3tm1Karl
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Scn5atm1Clhh/Scn5a+
Genetic Background: involves: 129 * 129S/SvEv * C57BL/6J

Allelic Composition: Scn5atm1Care/Scn5a+
Genetic Background: FVB.129P2-Scn5atm1Care

Allelic Composition: Scn5atm2.1(SCN5A)Rdn/Scn5atm2.1(SCN5A)Rdn
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Scn5atm3(SCN5A*)Rdn/Scn5atm3(SCN5A*)Rdn
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Scn5atm2.1Care/Scn5atm2.1Care
Genetic Background: B6J.129P2(Cg)-Scn5atm2.1Care

 MP:0004567 decreased myocardial fiber number "decreased number of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cst3tm1Karl/Cst3tm1Karl
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Capn1tm1.1Arte/Capn1tm1.1Arte,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6

Allelic Composition: Scn5atm1(SCN5A)Rdn/Scn5atm3(SCN5A*)Rdn
Genetic Background: involves: 129S6/SvEvTac

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cst3tm1Karl/Cst3tm1Karl
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
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Allelic Composition: Gja1tm1Kdr/Gja1tm1Kdr,Tg(CMV-Gja1)BClo/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * SJL/J * SWR/J

Allelic Composition: Scn5atm1Agrc/Scn5a+
Genetic Background: involves: 129/Sv

Allelic Composition: Scn5atm1Care/Scn5a+
Genetic Background: FVB.129P2-Scn5atm1Care

Allelic Composition: Scn5atm3(SCN5A*)Rdn/Scn5atm3(SCN5A*)Rdn
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Scn5atm1(SCN5A)Rdn/Scn5atm3(SCN5A*)Rdn
Genetic Background: involves: 129S6/SvEvTac

 MP:0006141 abnormal atrioventricular node conduction "anomaly in the generation or transfer of cardiac electrical impulses from the atrioventricular node to the atrioventricular bundle " [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Scn5atm1Clhh/Scn5a+
Genetic Background: involves: 129/SvEv

 MP:0006142 abnormal sinoatrial node conduction "anomaly in the generation or transfer of electrical impulses that trigger contraction of the atria and ventricles" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Scn5atm1Care/Scn5a+
Genetic Background: FVB.129P2-Scn5atm1Care

Allelic Composition: Scn5atm3(SCN5A*)Rdn/Scn5atm3(SCN5A*)Rdn
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Scn5atm1Clhh/Scn5a+
Genetic Background: involves: 129/SvEv

 MP:0008022 dilated heart ventricles "the lumenal space of the lower chambers of the heart is increased in volume or area, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Scn5atm3(SCN5A*)Rdn/Scn5atm3(SCN5A*)Rdn
Genetic Background: involves: 129S6/SvEvTac

 MP:0008543 atrial fibrillation "asynchronous contraction or quivering of individual cardiac muscle fibers in the atria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Scn5atm3(SCN5A*)Rdn/Scn5atm3(SCN5A*)Rdn
Genetic Background: involves: 129S6/SvEvTac

 MP:0008950 ventricular tachycardia "paroxysmal rapid beating of the heart originating in an ectopic focus in the heart ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cst3tm1Karl/Cst3tm1Karl
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Scn5atm1Agrc/Scn5a+
Genetic Background: involves: 129/Sv

Allelic Composition: Scn5atm1Clhh/Scn5a+
Genetic Background: involves: 129 * 129S/SvEv * C57BL/6J

Allelic Composition: Scn5atm3(SCN5A*)Rdn/Scn5atm3(SCN5A*)Rdn
Genetic Background: involves: 129S6/SvEvTac

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Scn5atm1Clhh/Scn5a+
Genetic Background: involves: 129 * 129S/SvEv * C57BL/6J

 MP:0010392 prolonged QRS complex duration "increase in the length of time of the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarize prior to their contraction; prolongation of the QRS complex duration reflects slowed conduction in the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Scn5atm1Agrc/Scn5a+
Genetic Background: involves: 129/Sv

Allelic Composition: Scn5atm1Care/Scn5a+
Genetic Background: FVB.129P2-Scn5atm1Care

Allelic Composition: Scn5atm3(SCN5A*)Rdn/Scn5atm3(SCN5A*)Rdn
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Scn5atm1(SCN5A)Rdn/Scn5atm3(SCN5A*)Rdn
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Scn5atm1Clhh/Scn5a+
Genetic Background: involves: 129/SvEv

Allelic Composition: Scn5atm2.1Care/Scn5atm2.1Care
Genetic Background: B6J.129P2(Cg)-Scn5atm2.1Care

 MP:0010393 shortened QRS complex duration "decrease in the length of time of the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarize prior to their contraction; prolongation of the QRS complex duration reflects slowed conduction in the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Scn5atm2.1(SCN5A)Rdn/Scn5atm2.1(SCN5A)Rdn
Genetic Background: involves: 129S6/SvEvTac

 MP:0010505 abnormal T wave "any anomaly in the T wave which is normally caused by the repolarization (or recovery) of the ventricles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Scn5atm1Pec/Scn5a+
Genetic Background: involves: Swiss

 MP:0010508 abnormal heart electrocardiography waveform feature "any anomaly in the pattern of the graphic record of the integrated action currents of the cardiac cycle represented as changes in voltage; the prominent waves in the ECG correspond to specific conduction activity in areas of the heart and the timing and amplitude of ECG waveforms provide valuable information about heart rate and rhythm" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:20410536]
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Allelic Composition: Scn5atm3(SCN5A*)Rdn/Scn5atm3(SCN5A*)Rdn
Genetic Background: involves: 129S6/SvEvTac

 MP:0010511 shortened PR interval "decrease in the length of time between the beginning of atrial depolarization and the beginning of ventricular depolarization, measured by the interval from the beginning of the P wave to the beginning of the QRS complex" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Scn5atm2.1(SCN5A)Rdn/Scn5atm2.1(SCN5A)Rdn
Genetic Background: involves: 129S6/SvEvTac

 MP:0010519 atrioventricular block "a partial or complete obstruction of the impulse that originates in the atria or sinoatrial node from reaching or transmitting through the atrioventricular node to the ventricles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Scn5atm3(SCN5A*)Rdn/Scn5atm3(SCN5A*)Rdn
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Scn5atm1Clhh/Scn5a+
Genetic Background: involves: 129/SvEv

 MP:0010637 sinus bradycardia "a type of decreased heart rhythm in which fewer than the normal number of impulses arise from the sinoatrial (SA) node" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Scn5atm1Clhh/Scn5a+
Genetic Background: involves: 129/SvEv

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Scn5atm1Clhh/Scn5a+
Genetic Background: involves: 129 * 129S/SvEv * C57BL/6J

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Scn5atm1Clhh/Scn5atm1Clhh
Genetic Background: involves: 129 * 129S/SvEv * C57BL/6J

Allelic Composition: Scn5atm1Care/Scn5atm1Care
Genetic Background: FVB.129P2-Scn5atm1Care

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cst3tm1Karl/Cst3tm1Karl
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Scn5atm1Pec/Scn5atm1Pec
Genetic Background: involves: Swiss

 MP:0011953 prolonged PQ interval "increase in the length of time between the beginning of atrial depolarization and the end of atrial repolarization (or recovery), measured by the interval from the beginning of the P wave to the end of the Q wave" [MPD:Molly]
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Allelic Composition: Scn5atm1Care/Scn5a+
Genetic Background: FVB.129P2-Scn5atm1Care

 MP:0013241 embryo tissue necrosis "morphological changes resulting from pathological death of some or all embryo tissue; usually due to irreversible damage" [MGI:csmith]
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Allelic Composition: Scn5atm1Clhh/Scn5atm1Clhh
Genetic Background: involves: 129 * 129S/SvEv * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000019194 Scn1b / P97952 / Sodium channel subunit beta-1 / Q07699* / sodium voltage-gated channel beta subunit 1*  / complex






 

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